{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T14:21:44Z","timestamp":1765808504607,"version":"3.48.0"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>\n                    Proliferative vascular disorders are rare congenital tumor-like lesions that arise from anomalies in blood vessel development. A newborn Assaf lamb presented with a diffuse, multinodular, dark-red overgrowth of the periodontal gingiva, accompanied by refusal to suckle. The animal developed diarrhea and died 2\u202fdays after birth. Necropsy was performed, and histopathological examination of the oral lesions revealed a marked expansion of the gingival stroma by multiple, closely packed, small- to medium-sized vascular channels. These were lined by a single layer of von Willebrand factor- and vimentin-positive endothelial cells and were partially surrounded by alpha smooth muscle actin (\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -SMA) - and vimentin-positive spindle cells, consistent with well-differentiated capillaries and post-capillary venules. Taken together, these findings were consistent with diffuse vascular gingival hamartomatosis\/angiomatosis. The congenital nature and distribution of the lesions are supportive of a malformation of the periodontal vasculature.\n                  <\/jats:p>","DOI":"10.3389\/fvets.2025.1702299","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T14:16:48Z","timestamp":1765808208000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Congenital gingival angiomatosis in a newborn lamb"],"prefix":"10.3389","volume":"12","author":[{"given":"D.","family":"Zapico","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Criado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Mend\u00edvil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Benavides","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C.","family":"Ferreras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Espinosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/S13620-015-0055-0","article-title":"Profiling oral and digital lesions in sheep in Ireland","volume":"68","author":"Fitzgerald","year":"2015","journal-title":"Ir Vet J"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/J.TVJL.2006.10.024","article-title":"The development of oral lesions in lambs naturally infected with orf virus","volume":"174","author":"McElroy","year":"2007","journal-title":"Vet J"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1590\/S0100-736X2016001100003","article-title":"Epidemiological, clinical and pathological aspects of an outbreak of periodontitis in sheep","volume":"36","author":"Silva","year":"2016","journal-title":"Pesqui Vet Bras"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1080\/00480169.1990.35641","article-title":"Dentigerous cysts (ovine odontogenic cysts) in sheep","volume":"38","author":"Gardner","year":"1990","journal-title":"N Z Vet J"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1111\/J.1600-0714.1992.TB00968.X","article-title":"Odontogenic cysts of the anterior mandible of sheep","volume":"21","author":"Gardner","year":"1992","journal-title":"J Oral Pathol Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1080\/00480169.1971.33933","article-title":"Neoplasms of sheep: a survey of 256 cases recorded at ruakura animal health laboratory","volume":"19","author":"Cordes","year":"1971","journal-title":"N Z Vet J"},{"key":"ref7","author":"Ross","year":"1984"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/S0007-1935(17)33387-0","article-title":"Sheep tumours in north East Yorkshire. I. Prevalence on seven moorland farms","volume":"134","author":"McCrea","year":"1978","journal-title":"Br Vet J"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1007\/S00580-011-1301-9","article-title":"An unusual squamous cell carcinoma in a sheep: a case report","volume":"21","author":"Namjoo","year":"2012","journal-title":"Comp Clin Pathol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S0921-4488(97)00082-5","article-title":"Ossifying fibroma in a sheep","volume":"28","author":"Rogers","year":"1998","journal-title":"Small Rumin Res"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1177\/030098588201900310","article-title":"An odontoameloblastoma in an adult sheep","volume":"19","author":"Dubielzig","year":"1982","journal-title":"Vet Pathol"},{"key":"ref12","first-page":"85","article-title":"Gingival hemangioma in a sheep","volume":"3","author":"Mousavi","year":"2022","journal-title":"Iran J Vet Surg"},{"key":"ref13","article-title":"Tumors of soft tissue","volume-title":"Surgical pathology of tumors of domestic animals","author":"Roccabianca","year":"2020"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/9781119181200.ch5","article-title":"Mesenchymal tumors of the skin and soft tissues","volume-title":"Tumors in domestic animals","author":"Hendrick","year":"2016"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1177\/0300985820980707","article-title":"A review of proliferative vascular disorders of the central nervous system of animals","volume":"58","author":"Marr","year":"2021","journal-title":"Vet Pathol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"205","DOI":"10.5555\/19842239397","article-title":"Vascular hamartoma in the gingiva of two neonatal calves","volume":"184","author":"Stanton","year":"1984","journal-title":"J Am Vet Med Assoc"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1177\/030098588101800415","article-title":"Vascular hamartomas in the gingiva of two calves","volume":"18","author":"Sheahan","year":"1981","journal-title":"Vet Pathol"},{"key":"ref18","first-page":"66","article-title":"Congenital gingival vascular hamartoma in a calf","volume":"5","author":"Yayla","year":"2016","journal-title":"Harran Univ Vet Fak Derg"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/S00580-006-0656-9\/FIGURES\/3","article-title":"Gingival vascular hamartoma in a young Holstein calf","volume":"16","author":"Mohammadi","year":"2007","journal-title":"Comp Clin Path"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1177\/104063879000200416","article-title":"Gingival vascular hamartoma in three calves","volume":"2","author":"Wilson","year":"1990","journal-title":"J Vet Diagn Invest"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1111\/J.1751-0813.2004.TB12641.X","article-title":"Gingival vascular hamartoma in two calves","volume":"82","author":"Yeruham","year":"2004","journal-title":"Aust Vet J"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"582","DOI":"10.4142\/JVS.2018.19.4.582","article-title":"Unilateral rostral mandibulectomy for gingival vascular hamartoma in two calves","volume":"19","author":"Tsuka","year":"2018","journal-title":"J Vet Sci"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"914","DOI":"10.2460\/JAVMA.1997.210.07.914","article-title":"Gingival vascular hamartoma with associated paraneoplastic hyperglycemia in a kitten","volume":"210","author":"Padgett","year":"1997","journal-title":"J Am Vet Med Assoc"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1292\/JVMS.18-0148","article-title":"Mandibular vascular hamartoma in a cat","volume":"80","author":"Takagi","year":"2018","journal-title":"J Vet Med Sci"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"36","DOI":"10.17221\/111\/2019-VETMED","article-title":"Cutaneous vascular hamartoma in a lamb","volume":"65","author":"Morais","year":"2020","journal-title":"Vet Med"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"101422","DOI":"10.1016\/J.CIMID.2020.101422","article-title":"Local assessment of WC1 + \u03b3\u03b4 T lymphocyte subset in the different types of lesions associated with bovine paratuberculosis","volume":"69","author":"Criado","year":"2020","journal-title":"Comp Immunol Microbiol Infect Dis"},{"key":"ref27","first-page":"821","article-title":"Congenital cutaneous hemangioma in a newborn lamb","volume-title":"Acta Sci Vet","author":"Nascimento","year":"2022"},{"key":"ref28","article-title":"The integument","volume-title":"Pathologic basis of disease","author":"Welle","year":"2022"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"340","DOI":"10.3390\/VETSCI9070340\/S1","article-title":"Identification of histopathological criteria for the diagnosis of canine cutaneous progressive angiomatosis","volume":"9","author":"Abramo","year":"2022","journal-title":"Vet Sci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/9781119221296","volume-title":"Veterinary oral and maxillofacial pathology","author":"Murphy","year":"2019"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1111\/J.1600-0765.1966.TB01851.X","article-title":"A study of periodontal vascularization 10 different laboratory animals","volume":"1","author":"Carranza","year":"1966","journal-title":"J Periodontal Res"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1111\/J.1600-0765.1966.TB01857.X","article-title":"The blood vessels of the dento-gingival junction","volume":"1","author":"Egelberg","year":"1966","journal-title":"J Periodontal Res"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.26463\/RJDS.15_2_21","article-title":"Gingival micro circulation: nature of vasculature","volume":"15","author":"Jain","year":"2023","journal-title":"RGUHS J Dent Sci"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/J.1600-0765.1986.TB01450.X","article-title":"The vasculature of the rat molar gingival crevice","volume":"21","author":"Weekes","year":"1986","journal-title":"J Periodontal Res"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1177\/03009858241241794","article-title":"ORF virus causes tumor-promoting inflammation in sheep and goats","volume":"61","author":"Pintus","year":"2024","journal-title":"Vet Pathol"},{"key":"ref36","first-page":"535","article-title":"The microscopic appearance of ecthyma contagiosum (Orf) in sheep, rabbits, and man","volume":"32","author":"Wheeler","year":"1956","journal-title":"Am J Pathol"}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2025.1702299\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T14:16:49Z","timestamp":1765808209000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2025.1702299\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,18]]},"references-count":36,"alternative-id":["10.3389\/fvets.2025.1702299"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2025.1702299","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,18]]},"article-number":"1702299"}}