{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:39:39Z","timestamp":1793227179672,"version":"4.5.0"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Light is an important environmental factor influencing animal production. In livestock production, light management techniques are common. They can enhance production and reproductive performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study investigated the effects of light wavelength on dairy cows. It focused on production, immunity, antioxidant capacity, and reproduction. It emphasized yellow light.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>In Experiment 1, 196 cows were divided into three groups and subjected to natural dark, red, and yellow light for 2 weeks. Results indicated yellow light was most effective. This prompted a second experiment. In Experiment 2, 80 postpartum cows received nocturnal yellow light until their next calving. Blood and milk samples were analyzed for immune, antioxidant, and reproductive markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The findings demonstrated that yellow light significantly enhanced milk yield (32.39\u201337.58 kg) and composition, including milk fat percentage, milk protein percentage, lactose percentage, milk urea nitrogen, and somatic cell count. It improved immune status (TNF-\u03b1: 181.10\u2013174.90 pg\/ml, IL-6: 117.30\u2013113.90 pg ml, IL-10: 31.18\u201332.86 pg\/ml), antioxidant status (superoxide dismutase: 111.80\u2013117.60 U\/ml, total antioxidant capacity: 8.28\u20138.76 U\/ml), and superior reproductive performance (the interval to first postpartum estrous cycle: 61.72 \u00b1 1.27 to 56.91 \u00b1 1.14 days, the pregnancy rate after first-insemination: 23.68 \u00b1 4.42% to 38.15 \u00b1 5.00%, the pregnancy days after first-insemination: 96.84 \u00b1 4.88 to 82.95 \u00b1 4.50 days). This was associated with enhanced melatonin levels in serum (36.30\u201359.48 pg\/ml) and milk (20.49\u201329.22 pg\/ml).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Nocturnal yellow light exposure, by elevating endogenous melatonin, is a viable non-invasive strategy to improve overall productivity, health, and welfare in dairy farming.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fvets.2025.1730661","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T14:03:26Z","timestamp":1768572206000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Yellow light improves milk quality, antioxidant capacity, immunity, and reproductive ability in dairy cows by elevating endogenous melatonin"],"prefix":"10.3389","volume":"12","author":[{"given":"Zixia","family":"Shen","sequence":"first","affiliation":[{"name":"National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agricultural, Beijing Key Laboratory for Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijia","family":"Wang","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agricultural, Beijing Key Laboratory for Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University","place":["Beijing, China"]},{"name":"Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent University","place":["Ghent, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuening","family":"Liu","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agricultural, Beijing Key Laboratory for Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangao","family":"Shan","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agricultural, Beijing Key Laboratory for Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agricultural, Beijing Key Laboratory for Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangdong","family":"Li","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agricultural, Beijing Key Laboratory for Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songyang","family":"Yao","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agricultural, Beijing Key Laboratory for Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjie","family":"Liu","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agricultural, Beijing Key Laboratory for Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laiqing","family":"Yan","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agricultural, Beijing Key Laboratory for Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyun","family":"Ji","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agricultural, Beijing Key Laboratory for Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agricultural, Beijing Key Laboratory for Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoshi","family":"Liu","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agricultural, Beijing Key Laboratory for Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.30802\/AALAS-JAALAS-23-000003","article-title":"Vivarium lighting as an important extrinsic factor influencing animal-based research","volume":"62","author":"Dauchy","year":"2023","journal-title":"J Am Assoc Lab Anim Sci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1433230","DOI":"10.3389\/fvets.2024.1433230","article-title":"Effects of Uv-B light exposure during automatic milking on vitamin D levels in holstein friesian cows","volume":"11","author":"Hodnik","year":"2025","journal-title":"Front Vet Sci"},{"key":"B3","doi-asserted-by":"publisher","first-page":"4855","DOI":"10.3168\/jds.2023-24209","article-title":"Creating models for the prediction of colostrum quantity, quality, and immunoglobulin g yield in multiparous jersey cows from performance in the previous lactation and environmental changes","volume":"107","author":"Stahl","year":"2024","journal-title":"J Dairy Sci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"3683","DOI":"10.3168\/jds.S0022-0302(04)73507-9","article-title":"Effects of photoperiod during the dry period on cellular immune function of dairy cows","volume":"87","author":"Auchtung","year":"2004","journal-title":"J Dairy Sci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"3145","DOI":"10.3168\/jds.S0022-0302(05)72997-0","article-title":"Short communication: short-day photoperiod during the dry period decreases expression of suppressors of cytokine signaling in mammary gland of dairy cows","volume":"88","author":"Wall","year":"2005","journal-title":"J Dairy Sci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.3168\/jds.2024-25415","article-title":"Changes in photoperiod during the dry period impact colostrum production in Holstein and Jersey cows","volume":"108","author":"Alward","year":"2025","journal-title":"J Dairy Sci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"626","DOI":"10.5187\/jast.2021.e59","article-title":"Effects of photoperiod and light intensity on milk production and milk composition of dairy cows in automatic milking system","volume":"63","author":"Lim","year":"2021","journal-title":"J Anim Sci Technol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1515\/pjvs-2017-0037","article-title":"Improvement of dairy cow embryo yield with low level laser irradiation","volume":"20","author":"Palubinskas","year":"2017","journal-title":"Pol J Vet Sci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"e13353","DOI":"10.1111\/asj.13353","article-title":"Exposure to blue led light before the onset of darkness under a long-day photoperiod alters melatonin secretion, feeding behaviour and growth in female dairy calves","volume":"91","author":"Elsabagh","year":"2020","journal-title":"Anim Sci J."},{"key":"B10","doi-asserted-by":"publisher","first-page":"G651","DOI":"10.1152\/ajpgi.00110.2019","article-title":"Possible application of melatonin treatment in human diseases of the biliary tract","volume":"317","author":"Baiocchi","year":"2019","journal-title":"Am J Physiol Gastrointest Liver Physiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.3390\/pharmaceutics15071845","article-title":"Pistacia Vera extract potentiates the effect of melatonin on human melatonin Mt1 and Mt2 receptors with functional selectivity","volume":"15","author":"Labani","year":"2023","journal-title":"Pharmaceutics."},{"key":"B12","doi-asserted-by":"publisher","first-page":"3927","DOI":"10.1007\/s00018-017-2616-8","article-title":"Melatonin transport into mitochondria","volume":"74","author":"Mayo","year":"2017","journal-title":"Cell Mol Life Sci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"562","DOI":"10.3168\/jds.S0022-0302(02)74109-X","article-title":"Protective effect of melatonin and catalase in bovine neutrophil-induced model of mammary cell damage1","volume":"85","author":"Boulanger","year":"2002","journal-title":"J Dairy Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.lfs.2017.02.008","article-title":"Association between light at night, melatonin secretion, sleep deprivation, and the internal clock: health impacts and mechanisms of circadian disruption","volume":"173","author":"Touitou","year":"2017","journal-title":"Life Sci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"106958","DOI":"10.1016\/j.domaniend.2025.106958","article-title":"Comparison of milk production and endocrine profiles of dairy cows exposed to either white light-emitting diode or induction lighting","volume":"93","author":"Inabu","year":"2025","journal-title":"Domest Anim Endocrinol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"591","DOI":"10.3390\/ani15040591","article-title":"Photoperiod management in farm animal husbandry: a review","volume":"15","author":"Li","year":"2025","journal-title":"Animals."},{"key":"B17","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.jphotobiol.2016.09.020","article-title":"Role of Monochromatic light on daily variation of clock gene expression in the pineal gland of chick","volume":"164","author":"Jiang","year":"2016","journal-title":"J Photochem Photobiol B: Biol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"6515","DOI":"10.20944\/preprints202505.2278.v1","article-title":"Monochromatic photophase light alters diurnal profiles of melatonin pathway indoles in the Rat Pineal gland","volume":"13","author":"Lewczuk","year":"2025","journal-title":"Int J Mol Sci"},{"key":"B19","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.jphysparis.2011.07.001","article-title":"Melatonin: both master clock output and internal time-giver in the circadian clocks network","volume":"105","author":"Pevet","year":"2011","journal-title":"J Physiol-Paris."},{"key":"B20","doi-asserted-by":"publisher","first-page":"e1002482","DOI":"10.1371\/journal.pbio.1002482","article-title":"Melanopsin regulates both sleep-promoting and arousal-promoting responses to light","volume":"14","author":"Pilorz","year":"2016","journal-title":"PLoS Biol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"431","DOI":"10.3390\/vetsci11090431","article-title":"Effect of exogenous melatonin on performance and mastitis in dairy cows","volume":"11","author":"Li","year":"2024","journal-title":"Vet Sci"},{"key":"B22","doi-asserted-by":"publisher","first-page":"834","DOI":"10.3390\/molecules26040834","article-title":"Effects of melatonin on dairy herd improvement (DHI) of holstein cow with high SCS","volume":"26","author":"Wu","year":"2021","journal-title":"Molecules"},{"key":"B23","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.3390\/agriculture12122109","article-title":"Associations of lameness with indicators of nitrogen metabolism and excretion in dairy cows","volume":"12","author":"Necula","year":"2022","journal-title":"Agriculture"},{"key":"B24","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.3168\/jds.2008-1777","article-title":"Interactions of energy and predicted metabolizable protein in determining nitrogen efficiency in the lactating dairy cow","volume":"93","author":"Rius","year":"2010","journal-title":"J Dairy Sci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"3068","DOI":"10.3390\/ani11113068","article-title":"Effects of milk urea nitrogen (MUN) and climatological factors on reproduction efficiency of holstein friesian and jersey cows in the subtropics","volume":"11","author":"Webb","year":"2021","journal-title":"Animals"},{"key":"B26","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1038\/s42255-025-01268-z","article-title":"Suppression of hypothalamic oestrogenic signal sustains hyperprolactinemia and metabolic adaptation in lactating mice","volume":"7","author":"Yu","year":"2025","journal-title":"Nat Metab."},{"key":"B27","doi-asserted-by":"publisher","first-page":"133659","DOI":"10.1016\/j.ijbiomac.2024.133659","article-title":"Dao J-j, Li Q, Liu C, Qiao C-m, Cui C, et al. Neuregulin 1 Mitigated prolactin deficiency through enhancing trpm8 signaling under the influence of melatonin in senescent pituitary lactotrophs","volume":"275","author":"Zhang","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1093\/biolre\/ioy223","article-title":"The inhibitory effect of melatonin on mammary function of lactating dairy goats","volume":"100","author":"Zhang","year":"2018","journal-title":"Biol Reprod."},{"key":"B29","doi-asserted-by":"publisher","first-page":"106000","DOI":"10.1016\/j.neubiorev.2024.106000","article-title":"Prolactin in sleep and eeg regulation: new mechanisms and sleep-related brain targets complement classical data","volume":"169","author":"T\u00f3th","year":"2025","journal-title":"Neurosci Biobehav Rev."},{"key":"B30","doi-asserted-by":"publisher","first-page":"656","DOI":"10.3390\/antiox14060656","article-title":"Redox imbalance in inflammation: the interplay of oxidative and reductive stress","volume":"14","author":"Bellanti","year":"2025","journal-title":"Antioxidants."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.1016\/j.bcp.2010.07.041","article-title":"Melatonin: a pleiotropic molecule regulating inflammation","volume":"80","author":"Radogna","year":"2010","journal-title":"Biochem Pharmacol."},{"key":"B32","first-page":"253","article-title":"The effect of low intensity laser irradiation of inflamed udders on the efficacy of antibiotic treatment of clinical mastitis in dairy cows","volume":"55","author":"Malinowski","year":"2019","journal-title":"Vet Ital."},{"key":"B33","doi-asserted-by":"publisher","first-page":"57","DOI":"10.4103\/ijd.ijd_11_24","article-title":"Assessment of systemic oxidative stress modulation in melasma following treatment with yellow light laser 577 Nm and topical 0","volume":"70","author":"Khurana","year":"2025","journal-title":"Indian J Dermatol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"e70879","DOI":"10.1111\/jcmm.70879","article-title":"Melatonin ameliorates desiccation stress-induced ocular inflammation in an in vitro model by activating the Nrf2 pathway","volume":"29","author":"Lim","year":"2025","journal-title":"J Cell Mol Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"e0178525","DOI":"10.1371\/journal.pone.0178525","article-title":"The anti-inflammatory and antioxidant effects of melatonin on lps-stimulated bovine mammary epithelial cells","volume":"12","author":"Yu","year":"2017","journal-title":"PLoS ONE."},{"key":"B36","doi-asserted-by":"publisher","first-page":"20250379","DOI":"10.1515\/tnsci-2025-0379","article-title":"The role of melatonin in affecting cognitive dysfunction in acute sleep deprivation mice through the nuclear factor kappab pathway and oxidative stress","volume":"16","author":"Li","year":"2025","journal-title":"Transl Neurosci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s11250-017-1253-4","article-title":"Mastitis effects on reproductive performance in dairy cattle: a review","volume":"49","author":"Kumar","year":"2017","journal-title":"Trop Anim Health Prod."},{"key":"B38","doi-asserted-by":"publisher","first-page":"767","DOI":"10.3390\/ani15060767","article-title":"Effects of oxidative stress and antioxidant activity in plasma and uterine fluid during early postpartum on subsequent reproductive performance of Japanese black cows","volume":"15","author":"Hagita","year":"2025","journal-title":"Animals"},{"key":"B39","doi-asserted-by":"publisher","first-page":"292","DOI":"10.3390\/antiox11020292","article-title":"Melatonin as a smart protector of pregnancy in dairy cows","volume":"11","author":"Dirandeh","year":"2022","journal-title":"Antioxidants"},{"key":"B40","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.aninu.2024.08.007","article-title":"The role of milk urea nitrogen in nutritional assessment and its relationship with phenotype of dairy cows: a review","volume":"20","author":"Zhao","year":"2025","journal-title":"Anim Nutr."}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2025.1730661\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T14:03:27Z","timestamp":1768572207000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2025.1730661\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,16]]},"references-count":40,"alternative-id":["10.3389\/fvets.2025.1730661"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2025.1730661","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,16]]},"article-number":"1730661"}}