{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T05:36:05Z","timestamp":1767591365106,"version":"3.48.0"},"reference-count":96,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypoadrenocorticism (HA) with hyponatremia and hyperkalemia represents primary disease and indicates cortisol and aldosterone insufficiency. Treatment involves replacement of mineralocorticoids and glucocorticoids. There are currently no studies comparing the efficacy and side effects of different treatment protocols.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to compare different treatment protocols for dogs with hyponatremic and hyperkalemic HA regarding their efficacy and side effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Two hundred forty-four dogs with HA with electrolyte anomalies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were collected via a standardized online questionnaire (available in english and german), which caregivers of affected dogs completed. The questionnaire was given to clients and was spread in online media.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 244 complete questionnaires were received (109 german and 135 english). Of those 244 participating dogs, 126 were female and 118 were male. Based on the treatment applied, the following groups were assigned: prednisolone and desoxycorticosterone pivalate (DOCP, Zycortal\u00ae) (ZP,\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f167), prednisolone and desoxycorticosterone pivalate (DOCP, Percorten-V\u00ae) (PP,\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f39), prednisolone and fludrocortisone (FP,\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f23) and fludrocortisone (F,\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f15). The median prednisolone dose was 0.07\u202fmg\/kg\/day in the ZP and 0.08\u202fmg\/kg\/day in the FP group and was slightly lower in the PP group with 0.04\u202fmg\/kg\/day. Median DOCP dose was 0.88\u202fmg\/kg every 28\u202fdays in the ZP group and 0.78\u202fmg\/kg every 28\u202fdays in the PP group. Fludrocortisone was dosed with 0.02\u202fmg\/kg\/day in the FP and F group. All treatment strategies led to a normal activity, quality of life of dog and caregiver, and achieved satisfaction with therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Good clinical disease control can be achieved with any of the above strategies. Applied DOCP dose were lower than previously reported and can be combined safely with low prednisolone dosages.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fvets.2025.1735233","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T05:32:05Z","timestamp":1767591125000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and side effects of long-term treatment strategies of canine primary hypoadrenocorticism"],"prefix":"10.3389","volume":"12","author":[{"given":"Deborah Anna","family":"Dobosz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yury","family":"Zablotski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid","family":"Wehner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"ref1","author":"Kelch","year":"1996"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/jvim.13815","article-title":"Naturally occurring adrenocortical insufficiency\u2013an epidemiological study based on a swedish-insured dog population of 525,028 dogs","volume":"30","author":"Hanson","year":"2016","journal-title":"J Vet Intern Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.jcpa.2012.11.242","article-title":"Correlation of inflammation with adrenocortical atrophy in canine adrenalitis","volume":"149","author":"Frank","year":"2013","journal-title":"J Comp Pathol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"85","DOI":"10.2460\/javma.1996.208.01.85","article-title":"Pretreatment clinical and laboratory findings in dogs with hypoadrenocorticism: 225 cases (1979-1993)","volume":"208","author":"Peterson","year":"1996","journal-title":"J Am Vet Med Assoc"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/jvim.12243","article-title":"Evaluation of aldosterone concentrations in dogs with hypoadrenocorticism","volume":"28","author":"Baumstark","year":"2014","journal-title":"J Vet Internal Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"643","DOI":"10.2460\/ajvr.2002.63.643","article-title":"Inheritance of hypoadrenocorticism in bearded collies","volume":"63","author":"Oberbauer","year":"2002","journal-title":"Am J Vet Res"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"407","DOI":"10.2460\/javma.231.3.407","article-title":"Clinical features and heritability of hypoadrenocorticism in Nova Scotia duck tolling retrievers: 25 cases (1994-2006)","volume":"231","author":"Hughes","year":"2007","journal-title":"J Am Vet Med Assoc"},{"key":"ref8","first-page":"485","article-title":"Hypoadreocorticism in dogs","volume-title":"Canine and Feline Endocrinology","author":"Scott-Moncrieff","year":"2014"},{"key":"ref9","first-page":"1795","article-title":"Hypoadrenocorticism in dogs","author":"Scott-Moncrieff","year":"2017","journal-title":"Textbook of Veterinary Internal Medicine"},{"key":"ref10","first-page":"1168","volume-title":"J Vet Intern Med.","author":"Adler","year":"2007"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1748-5827.2009.00757.x","article-title":"Calcium metabolism in eight dogs with hypoadrenocorticism","volume":"50","author":"Gow","year":"2009","journal-title":"J Small Anim Pract"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1111\/jvim.15752","article-title":"Prevalence and characterization of hypoadrenocorticism in dogs with signs of chronic gastrointestinal disease: a multicenter study","volume":"34","author":"Hauck","year":"2020","journal-title":"J Vet Intern Med"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/S0195-5616(97)50036-2","article-title":"Primary and secondary canine hypoadrenocorticism","volume":"27","author":"Kintzer","year":"1997","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"ref14","first-page":"148","article-title":"Diagnosis and management of primary spontaneous hypoadrenocorticism (Addison's disease) in dogs","volume":"9","author":"Kintzer","year":"1994","journal-title":"Semin Vet Med Surg Small Anim"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1111\/avj.12019","article-title":"Lower initial dose desoxycorticosterone pivalate for treatment of canine primary hypoadrenocorticism","volume":"91","author":"Bates","year":"2013","journal-title":"Aust Vet J"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1136\/vr.i4052","article-title":"How best to treat Addison's disease in dogs?","volume":"179","author":"Carr","year":"2016","journal-title":"Vet Rec"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/j.1939-1676.1997.tb00072.x","article-title":"Treatment and long-term follow-up of 205 dogs with hypoadrenocorticism","volume":"11","author":"Kintzer","year":"1997","journal-title":"J Vet Internal Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"392","DOI":"10.2460\/javma.1993.202.03.392","article-title":"Efficacy of microcrystalline desoxycorticosterone pivalate for treatment of hypoadrenocorticism in dogs. DOCP clinical study group","volume":"202","author":"Lynn","year":"1993","journal-title":"J Am Vet Med Assoc"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1111\/jvim.15475","article-title":"Evaluation of a low-dose desoxycorticosterone pivalate treatment protocol for long-term management of dogs with primary hypoadrenocorticism","volume":"33","author":"Sieber-Ruckstuhl","year":"2019","journal-title":"J Vet Intern Med"},{"key":"ref20","article-title":"Package insert for Percorten\u00ae-V (desoxycorticosterone pivalate)","year":"1998"},{"key":"ref21","article-title":"Package insert for Zycortal\u00ae (desoxycorticosterone pivalate)","year":"2016"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"151","DOI":"10.5326\/15473317-31-2-151","article-title":"Subcutaneous administration of desoxycorticosterone pivalate for the treatment of canine hypoadrenocorticism","volume":"31","author":"McCabe","year":"1995","journal-title":"J Am Anim Hosp Assoc"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"2595","DOI":"10.1111\/jvim.15639","article-title":"Development and evaluation of a health-related quality-of-life tool for dogs with Cushing's syndrome","volume":"33","author":"Schofield","year":"2019","journal-title":"J Vet Internal Med"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1111\/j.1939-1676.2012.00947.x","article-title":"Evaluation of a quality-of-life tool for dogs with diabetes mellitus","volume":"26","author":"Niessen","year":"2012","journal-title":"J Vet Intern Med"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"e1977","DOI":"10.1002\/vetr.1977","article-title":"Effect of long-term management of hypoadrenocorticism on the quality of life of affected dogs and their owners","volume":"191","author":"Hupfeld","year":"2022","journal-title":"Vet Rec"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1892\/0891-6640(2007)21[700:ceideo]2.0.co;2","article-title":"Chronic enteropathies in dogs: evaluation of risk factors for negative outcome","volume":"21","author":"Allenspach","year":"2007","journal-title":"J Vet Intern Med"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.2460\/javma.242.11.1549","article-title":"Prevalence of inherited disorders among mixed-breed and purebred dogs: 27,254 cases (1995-2010)","volume":"242","author":"Bellumori","year":"2013","journal-title":"J Am Vet Med Assoc"},{"key":"ref28","first-page":"63","article-title":"Canine hypoadrenocorticism: part I","volume":"51","author":"Klein","year":"2010","journal-title":"Can Vet J"},{"key":"ref29","first-page":"141","article-title":"Inc. Freedom of Information Summary for Percorten\u00ae-V (desoxycorticosterone pivalate)","year":"1988"},{"key":"ref30","first-page":"141","article-title":"Freedom of Information Summary for Zycortal\u00ae (desoxycorticosterone pivalate)","year":"2016"},{"key":"ref31","article-title":"CVMP assessment report for Zycortal\u00ae","year":"2015"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1111\/jvim.12426","article-title":"Use of plasma renin activity to monitor mineralocorticoid treatment in dogs with primary hypoadrenocorticism: desoxycorticosterone versus fludrocortisone","volume":"28","author":"Baumstark","year":"2014","journal-title":"J Vet Intern Med"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1111\/jvim.14828","article-title":"Desoxycorticosterone pivalate duration of action and individualized dosing intervals in dogs with primary hypoadrenocorticism","volume":"31","author":"Jaffey","year":"2017","journal-title":"J Vet Internal Med"},{"key":"ref34","first-page":"1192","article-title":"Treatment of hypoadrenocorticism in dogs","volume":"202","author":"Pascoe","year":"1993","journal-title":"J Am Vet Med Assoc"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1055\/a-1166-8800","article-title":"Therapy of primary hypoadrenocorticism in dogs with low dose desoxycorticosterone pivalate","volume":"48","author":"M\u00fcnch","year":"2020","journal-title":"Tierarztliche Praxis Ausgabe K, Kleintiere Heimtiere"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1111\/jvim.16195","article-title":"Low-dose desoxycorticosterone pivalate treatment of hypoadrenocorticism in dogs: a randomized controlled clinical trial","volume":"35","author":"Vincent","year":"2021","journal-title":"J Vet Intern Med"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.2460\/javma.1993.202.11.1869","article-title":"Severe gastrointestinal tract hemorrhage in three dogs with hypoadrenocorticism","volume":"202","author":"Medinger","year":"1993","journal-title":"J Am Vet Med Assoc"},{"key":"ref38","first-page":"167","article-title":"Addison's disease (hypoadrenocorticism) in dogs","volume-title":"Eur J Comp Anim Pract","author":"Mooney","year":"2007"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1136\/inpract.25.1.18","article-title":"Diagnosis and treatmnent of canine hypoadrenocorticism","volume":"25","author":"Ramsey","year":"2003","journal-title":"In Pract"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/j.1748-5827.1996.tb02377.x","article-title":"Diagnosis and treatment of naturally occurring hypoadrenocorticism in 42 dogs","volume":"37","author":"Melian","year":"1996","journal-title":"J Small Anim Pract"},{"key":"ref41","first-page":"167","article-title":"A comparison of the ACTH concentrations in dogs with stable hypoadrenocorticism being treated with either fludrocortisone or desoxycortone pivalate and prednisolone","volume-title":"27th ECVIM-CA congress proceedings","author":"Spence","year":"2017"},{"key":"ref42","first-page":"729","article-title":"Glucocorticoids, mineralocorticoids, and adrenolytic drugs","volume-title":"Veterinary pharmacology and therapeutics","author":"Ferguson","year":"2018"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2147\/VMRR.S146774","article-title":"Management of hypoadrenocorticism (Addison's disease) in dogs","volume":"9","author":"Lathan","year":"2018","journal-title":"Vet Med"},{"key":"ref44","article-title":"Hypoadrenocorticism (Addison's disease)","volume-title":"Canine and feline endocrinology and reproduction","author":"Feldman","year":"2004"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/S0195-5616(84)50079-5","article-title":"Hypoadrenocorticism","volume":"14","author":"Feldman","year":"1984","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"ref46","first-page":"716","article-title":"Hypoadrenocorticism (Addison\u2019s disease)","volume-title":"The 5 minute veterinary consult","author":"Kintzer","year":"1997"},{"key":"ref47","first-page":"1488","article-title":"Hypoadrenocorticism","volume-title":"Textbook of veterinary internal medicine","author":"Reusch","year":"2000"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"156","DOI":"10.22233\/9781905319893.15","article-title":"Canine hypoadrenocorticism","volume-title":"BSAVA manual of canine and feline endocrinology","author":"Church","year":"2012"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/9781118997093.ch1","article-title":"Hypoadrenocorticism in dogs","volume-title":"Clinical endocrinology of companion animals","author":"Lathan","year":"2013"},{"key":"ref50","first-page":"179","article-title":"Canine hypoadrenocorticism: part II","volume":"51","author":"Klein","year":"2010","journal-title":"Can Vet J"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"90","DOI":"10.15654\/TPK-170668","article-title":"Prednisolone dosages in Addisonian dogs after integration of ACTH measurement into treatment surveillance","volume":"46","author":"Zeugswetter","year":"2018","journal-title":"Tierarztliche Praxis Ausgabe K, Kleintiere Heimtiere"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1080\/01652176.2013.826881","article-title":"A retrospective study of oral prednisolone treatment in canine chronic hepatitis","volume":"33","author":"Favier","year":"2013","journal-title":"Vet Q"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1111\/jsap.12652","article-title":"Serial measurement of pancreatic lipase immunoreactivity concentration in dogs with immune-mediated disease treated with prednisolone","volume":"58","author":"Ohta","year":"2017","journal-title":"J Small Anim Pract"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"571457","DOI":"10.3389\/fvets.2020.571457","article-title":"Pharmacokinetics of Oral prednisone at various doses in dogs: preliminary findings using a na\u00efve pooled-data approach","volume":"7","author":"Sebbag","year":"2020","journal-title":"Front Vet Sci"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1111\/j.1939-1676.2011.00830.x","article-title":"White blood cell count and the sodium to potassium ratio to screen for hypoadrenocorticism in dogs","volume":"25","author":"Seth","year":"2011","journal-title":"J Vet Internal Med."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.2460\/javma.230.8.1190","article-title":"Comparison of classic hypoadrenocorticism with glucocorticoid-deficient hypoadrenocorticism in dogs: 46 cases (1985-2005)","volume":"230","author":"Thompson","year":"2007","journal-title":"J Am Vet Med Assoc"},{"key":"ref57","first-page":"136","article-title":"Prednisone treatment alters the serum amylase and lipase activities in normal dogs without causing pancreatitis","volume":"48","author":"Fittschen","year":"1984","journal-title":"Can J Comp Med"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1136\/vr.143.4.114","article-title":"Reasons for the euthanasia of dogs and cats","volume":"143","author":"Edney","year":"1998","journal-title":"Vet Rec"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"722","DOI":"10.2460\/javma.2005.226.722","article-title":"Quality-of-life assessment in pet dogs","volume":"226","author":"Wojciechowska","year":"2005","journal-title":"J Am Vet Med Assoc"},{"key":"ref60","year":"2006"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1254\/jphs.CP0070034","article-title":"Gastroprotective role of glucocorticoid hormones","volume":"104","author":"Filaretova","year":"2007","journal-title":"J Pharmacol Sci"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1152\/ajplegacy.1970.219.5.1342","article-title":"Intestinal vasoconstriction after hemorrhage: roles of vasopressin and angiotensin","volume":"219","author":"McNeill","year":"1970","journal-title":"Am J Phys"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"e0192198","DOI":"10.1371\/journal.pone.0192198","article-title":"Long-term effects of canine parvovirus infection in dogs","volume":"13","author":"Kilian","year":"2018","journal-title":"PLoS One"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1111\/cea.12356","article-title":"Prenatal and post-natal exposure to antibiotics and risk of asthma in childhood","volume":"45","author":"Mets\u00e4l\u00e4","year":"2015","journal-title":"Clin Exp Allergy"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1038\/ajg.2014.246","article-title":"Antibiotics associated with increased risk of new-onset Crohn\u2019s disease but not ulcerative colitis: a meta-analysis","volume":"109","author":"Ungaro","year":"2014","journal-title":"Am J Gastroenterol"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1542\/peds.2014-3407","article-title":"Antibiotic exposure in infancy and risk of being overweight in the first 24 months of life","volume":"135","author":"Saari","year":"2015","journal-title":"Pediatrics"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1016\/j.jaci.2009.08.017","article-title":"Antibiotic use in infancy and symptoms of asthma, rhinoconjunctivitis, and eczema in children 6 and 7 years old: international study of asthma and allergies in childhood phase III","volume":"124","author":"Foliaki","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.molmed.2016.04.003","article-title":"Antibiotic-induced changes in the intestinal microbiota and disease","volume":"22","author":"Becattini","year":"2016","journal-title":"Trends Mol Med"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/s41591-019-0406-6","article-title":"Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer","volume":"25","author":"Wirbel","year":"2019","journal-title":"Nat Med"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1038\/s41467-017-01973-8","article-title":"Meta-analysis of gut microbiome studies identifies disease-specific and shared responses","volume":"8","author":"Duvallet","year":"2017","journal-title":"Nat Commun"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1159\/000443360","article-title":"Effects of antibiotics on gut microbiota","volume":"34","author":"Lange","year":"2016","journal-title":"Dig Dis"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"7546047","DOI":"10.1155\/2019\/7546047","article-title":"The dynamic interplay between the gut microbiota and autoimmune diseases","volume":"2019","author":"Xu","year":"2019","journal-title":"J Immunol Res"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.anaerobe.2015.04.002","article-title":"Microbiota and probiotics in canine and feline welfare","volume":"34","author":"Grze\u015bkowiak","year":"2015","journal-title":"Anaerobe"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.3390\/ani13152479","article-title":"Characterization of the gut microbiome in healthy dogs and dogs with diabetes mellitus","volume":"13","author":"Kwong","year":"2023","journal-title":"Animals"},{"key":"ref75","first-page":"340","article-title":"Chronic diarrhea in the diabetic. A review of the literature","volume":"36","author":"Fr\u00edas Ordo\u00f1ez","year":"2016","journal-title":"Rev Gastroenterol Peru"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1038\/s41564-018-0257-9","article-title":"Recovery of gut microbiota of healthy adults following antibiotic exposure","volume":"3","author":"Palleja","year":"2018","journal-title":"Nat Microbiol"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"4554","DOI":"10.1073\/pnas.1000087107","article-title":"Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation","volume":"108","author":"Dethlefsen","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"3216","DOI":"10.1099\/mic.0.040618-0","article-title":"Long-term impacts of antibiotic exposure on the human intestinal 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cobalamin and methylmalonic acid concentrations in dogs","volume":"191","author":"Berghoff","year":"2012","journal-title":"Vet J"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.tvjl.2018.11.004","article-title":"Effects of oral versus parenteral cobalamin supplementation on methylmalonic acid and homocysteine concentrations in dogs with chronic enteropathies and low cobalamin concentrations","volume":"243","author":"Toresson","year":"2019","journal-title":"Vet J"},{"key":"ref84","volume-title":"Schalm's veterinary hematology","author":"Weiss","year":"2011"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.cvsm.2011.01.001","article-title":"Laboratory tests for the diagnosis and management of chronic canine and feline enteropathies","volume":"41","author":"Berghoff","year":"2011","journal-title":"Vet Clin North Am Small Anim 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