{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T23:14:40Z","timestamp":1773875680074,"version":"3.50.1"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Osteoarthritis (OA) is a progressive degenerative joint disease characterized by cartilage deterioration, leading to chronic pain and impaired immobility particularly in older dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      This study investigated the protective effects of a turmerosaccharides-rich extract of\n                      <jats:italic>Curcuma longa<\/jats:italic>\n                      L. in the management of canine OA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      Twenty dogs with OA were randomized into two treatment groups. One group received the\n                      <jats:italic>C. longa<\/jats:italic>\n                      extract orally at 300\u202fmg\/20\u202fkg body weight once daily for 42\u202fdays. The second group received glucosamine hydrochloride with chondroitin sulfate (Glu\/CS), administered orally for the same duration, according to the manufacturer\u2019s recommendations. Therapeutic response was evaluated using laboratory parameters, veterinarian, owner reported assessments, and radiological examination of the affected joints. Dogs were re-evaluated on days 49 and 56 following treatment withdrawal.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and discussion<\/jats:title>\n                    <jats:p>\n                      Both veterinarian and owner assessments demonstrated that the\n                      <jats:italic>C. longa<\/jats:italic>\n                      extract produced a significant reduction in pain and clinical signs associated with OA. The extract was palatable and well tolerated, with no adverse events observed throughout the study. Radiographic evaluation revealed no substantial changes in joint space or structural integrity. Collectively, these findings demonstrate turmerosaccharide-rich\n                      <jats:italic>C. longa<\/jats:italic>\n                      extract is a safe, well-accepted and clinically effective therapeutic option for the management of OA in dogs.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fvets.2026.1536366","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T15:29:21Z","timestamp":1773847761000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Protective effects of turmerosaccharides rich extract of Curcuma longa L. in osteoarthritic dogs"],"prefix":"10.3389","volume":"13","author":[{"given":"S. D.","family":"Tripathi","sequence":"first","affiliation":[{"name":"Department of Surgery and Radiology, Mumbai Veterinary College, Animal and Fishery Sciences University","place":["Nagpur, Maharashtra, India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Suresh","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Toxicology, R&D Centre, Natural Remedies Private Limited","place":["Bengaluru, Karnataka, India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prakash","family":"Khangal","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Toxicology, R&D Centre, Natural Remedies Private Limited","place":["Bengaluru, Karnataka, India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Sasi Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Toxicology, R&D Centre, Natural Remedies Private Limited","place":["Bengaluru, Karnataka, India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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