{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T17:07:58Z","timestamp":1771952878518,"version":"3.50.1"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pituitary somatotroph adenoma is rare in dogs and may cause hypersomatotropism (HS) leading to insulin resistance and diabetes mellitus (DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case description<\/jats:title>\n                    <jats:p>A 10-year-5-month-old neutered male Staffordshire Bull Terrier presented with polyuria, polydipsia, progressive inspiratory stridor, and poorly controlled DM with hyperinsulinemia and insulin resistance. Serum insulin-like growth factor (IGF-1) was markedly elevated (1,214\u202fng\/mL; reference interval, 42\u2013449\u202fng\/mL) and suggested HS which was further supported by a somatostatin suppression test. Magnetic resonance and computed tomography (CT) imaging revealed a pituitary mass, organomegaly, and arthropathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Treatment and outcome<\/jats:title>\n                    <jats:p>The pituitary mass was removed by transsphenoidal hypophysectomy. Immunohistochemistry confirmed a growth hormone (GH)-producing pituitary adenoma. Postoperatively, GH normalized within hours, and IGF-1 values within a week. Although HS resolved and hyperinsulinemia improved postoperatively, the dog remained dependent on insulin and DM persisted which eventually led to euthanasia of the dog about 9 and a half months post-operatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Transsphenoidal hypophysectomy was effective in normalization of GH and IGF-1 concentrations in a dog diagnosed with a pituitary somatotroph adenoma but the postoperative course was characterized by persistent insulin dependency and DM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fvets.2026.1740713","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T16:33:01Z","timestamp":1771950781000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Treatment of hypersomatotropism in a diabetic dog with transsphenoidal hypophysectomy"],"prefix":"10.3389","volume":"13","author":[{"given":"Anika S.","family":"Meij","sequence":"first","affiliation":[{"name":"Animal Referral Centre","place":["Auckland, New Zealand"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucinda Luvia","family":"Van Stee","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University","place":["Utrecht, Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hedwig S.","family":"Kruitwagen","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University","place":["Utrecht, Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert Cornelis","family":"van Nieuwaal-Jubbega","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University","place":["Utrecht, Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy C. M.","family":"Grinwis","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University","place":["Utrecht, Netherlands"]},{"name":"Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University","place":["Utrecht, Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Galac","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University","place":["Utrecht, Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn P.","family":"Meij","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University","place":["Utrecht, 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