{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T11:21:53Z","timestamp":1770808913772,"version":"3.50.0"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The extensive and intense itching caused by skin diseases can significantly diminish the quality of life for companion animals. Oral administration of oclacitinib maleate is recognized as an important treatment for alleviating itching. Oral medications are affected by the animal\u2019s temperament and swallowing ability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, we developed a temperature-responsive hydrogel containing oclacitinib maleate for rectal administration, and we evaluated its therapeutic potential for treating itching through pharmacokinetic analysis using rabbits as test subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Pharmacokinetic results indicated that the transrectal administration of OM T-R Hydrogel effectively increased the blood concentration of oclacitinib maleate (T\n                      <jats:sub>max<\/jats:sub>\n                      \u202f=\u202f87\u202fmin, C\n                      <jats:sub>max<\/jats:sub>\n                      \u202f=\u202f37\u202fng\/mL, t\n                      <jats:sub>1\/2\u03bbz<\/jats:sub>\n                      \u202f=\u202f762\u202fmin). Furthermore, the OM T-R Hydrogel demonstrated no rectal mucosal irritation, confirming its safety for clinical use.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In conclusion, this paper successfully investigated a promising novel drug delivery system to alleviate pruritus in dogs and cats.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fvets.2026.1767033","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T05:38:59Z","timestamp":1770788339000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Temperature-responsive hydrogel of oclacitinib maleate administered via the rectum in rabbit"],"prefix":"10.3389","volume":"13","author":[{"given":"PanPan","family":"Guo","sequence":"first","affiliation":[{"name":"College of Animal Sciences, Fujian Agriculture and Forestry University","place":["Fuzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Animal Sciences, Fujian Agriculture and Forestry University","place":["Fuzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongsheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Sciences, Fujian Agriculture and Forestry University","place":["Fuzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxin","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Animal Sciences, Fujian Agriculture and Forestry University","place":["Fuzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Mohsin","sequence":"additional","affiliation":[{"name":"Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine","place":["Fuzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Animal Sciences, Fujian Agriculture and Forestry University","place":["Fuzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dengfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Sciences, Fujian Agriculture and Forestry University","place":["Fuzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangwen","family":"Yin","sequence":"additional","affiliation":[{"name":"College of Animal Sciences, Fujian Agriculture and Forestry University","place":["Fuzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Sciences, Fujian Agriculture and Forestry University","place":["Fuzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1177\/1098612X13489222","article-title":"Dermatophytosis in cats: ABCD guidelines on prevention and management","volume":"15","author":"Frymus","year":"2013","journal-title":"J Feline Med Surg"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s12917-018-1477-1","article-title":"Auto-immune skin diseases in animals: time to reclassify and review after 40 years","volume":"14","author":"Olivry","year":"2018","journal-title":"BMC Vet Res"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1177\/1098612X18773911","article-title":"Owner-reported flea treatment measures and skin disease in cats","volume":"21","author":"Tyler","year":"2019","journal-title":"J Feline Med 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