{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:47:22Z","timestamp":1791388042161,"version":"4.3.3"},"reference-count":152,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>Porcine reproductive and respiratory syndrome (PRRS) is a highly infectious disease caused by the PRRS virus (PRRSV), its impact is second only to that of African swine fever (ASFV). Since the discovery of this disease, comprehensive studies have been conducted on its genome structure, protein function, pathogenicity, transmission route, and epidemiology as well as vaccines, prevention, and control. Despite the availability of numerous vaccines, complete immune protection in pigs is lacking. This limitation may be attributed to immune evasion, immunosuppression, or inherent characteristics of pigs. From the view of immunosuppression, the antigen escape, delayed neutralization antibody production, T cell immunity, antibody dependence enhancement, dendritic cell function inhibition, regulatory T cell induction and thymic destruction of PRRSV were discussed in this review to better understand PRRSV pathogenesis and inform vaccine development.<\/jats:p>","DOI":"10.3389\/fvets.2026.1775261","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:24:43Z","timestamp":1772169883000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Advances in the immunosuppression of porcine reproductive and respiratory syndrome virus"],"prefix":"10.3389","volume":"13","author":[{"given":"Huawei","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Animal Product Quality and Safety Technology, Henan University of Animal Husbandry and Economy","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Lv","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University","place":["Foshan, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruining","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Animal Product Quality and Safety Technology, Henan University of Animal Husbandry and Economy","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Animal Product Quality and Safety Technology, Henan University of Animal Husbandry and Economy","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangzong","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University","place":["Foshan, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University","place":["Foshan, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/S0378-4320(00)00135-4","article-title":"The effect of porcine parvovirus and porcine reproductive and respiratory syndrome virus on porcine 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