{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T13:54:03Z","timestamp":1776174843407,"version":"3.50.1"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>A 3.3-year-old castrated male domestic shorthair cat presented to the emergency service with neurologic signs. The cat had an extensive medical history, including previous treatment for esophageal strictures via balloon dilation. Diagnostics revealed a coagulopathy, a highly regenerative anemia, and marked thrombocytopenia. The cat\u2019s neurologic signs progressed rapidly, culminating in seizures and cardiac arrest. A necropsy revealed findings consistent with feline systemic reactive angioendotheliomatosis (FSRA), a rare, idiopathic, multisystemic, and uniformly fatal disease. To date, only 16 cases of FSRA have been reported in the veterinary literature, and very few provide detailed descriptions of attempted treatments. It is theorized that repeated tissue trauma from procedures, infection, and chronic inflammation may have triggered a more systemic response, contributing to the development of FSRA in this cat. Further investigation is needed to better understand this rare disease.<\/jats:p>","DOI":"10.3389\/fvets.2026.1778392","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T13:07:06Z","timestamp":1776172026000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Systemic reactive angioendotheliomatosis in a young cat with a history of esophageal strictures and balloon dilations"],"prefix":"10.3389","volume":"13","author":[{"given":"Tara","family":"Hammond","sequence":"first","affiliation":[{"name":"Department of Emergency and Critical Care, Tufts Veterinary Emergency Treatment & Specialties","place":["Walpole, MA, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Savidge","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tufts Veterinary Emergency Treatment & Specialties","place":["Walpole, MA, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisela","family":"Martinez-Romero","sequence":"additional","affiliation":[{"name":"Department of Comparative Pathobiology, Cummings School of Veterinary Medicine at Tufts University","place":["North Grafton, MA, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2055116915579684","DOI":"10.1177\/2055116915579684","article-title":"A case of feline systemic reactive angioendotheliomatosis","volume":"1","author":"Yamamoto","year":"2015","journal-title":"J Fel Med Surg"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1354\/vp.42-5-608","article-title":"Feline systemic reactive angioendotheliomatosis: eight cases and literature review","volume":"42","author":"Fuji","year":"2005","journal-title":"Vet Pathol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1136\/vr.140.5.128","article-title":"Fatal multisystemic intravascular lesions in a cat","volume":"140","author":"Dunn","year":"1997","journal-title":"Vet Rec"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1177\/030098588502200512","article-title":"Unusual multisystemic vascular lesion in a cat","volume":"22","author":"Rothwell","year":"1985","journal-title":"Vet Pathol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2460\/javma.21.03.0128","article-title":"Pathology in practice","volume":"18","author":"Raven","year":"2022","journal-title":"J Am Vet Med Assoc"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.jvc.2024.08.010","article-title":"Systemic reactive angioendotheliomatosis mimicking hypertrophic cardiomyopathy in a domestic shorthair cat","volume":"56","author":"Herrold","year":"2024","journal-title":"J Vet Cardiol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"E16","DOI":"10.1111\/vru.12374","article-title":"Imaging diagnosis\u2014magnetic resonance imaging findings in a cat with systemic reactive angioendotheliomatosis","volume":"58","author":"Schkeeper","year":"2017","journal-title":"Vet Radiol Ultrasound"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1111\/jvim.15071","article-title":"Prospective evaluation of indwelling esophageal balloon dilation feeding tube for treatment of benign esophageal strictures in dogs and cats","volume":"32","author":"Tan","year":"2018","journal-title":"J Vet Int Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1097\/00000372-199602000-00010","article-title":"Reactive angioendotheliomatosis. 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