{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:54:42Z","timestamp":1777870482041,"version":"3.51.4"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>Adrenal gland tumors are uncommon in dogs, and the simultaneous presence of epithelial and mesenchymal neoplasms within a single adrenal gland is exceptionally rare. We describe a rare case of an adrenocortical adenoma associated with a myelolipoma in a 7-year-old male Pekingese dog presented with acute abdominal pain and fever. Diagnostic imaging identified a well-defined mass in the right adrenal gland, with no evidence of vascular invasion or metastatic disease. Surgical adrenalectomy was subsequently performed. Histopathological evaluation revealed a well-circumscribed adrenocortical adenoma containing an intratumoral myelolipomatous component composed of mature adipose tissue and trilineage hematopoietic elements. Immunohistochemical analysis demonstrated Melan A positivity in the adenomatous component, while the myelolipomatous tissue showed diffuse vimentin expression and lacked Melan A immunoreactivity. The postoperative course was uneventful, and no recurrence was detected at one-year follow-up. This case underscores the diagnostic complexity of heterogeneous adrenal masses in dogs and highlights the essential role of histopathology and immunohistochemistry in the accurate identification of rare mixed adrenal lesions.<\/jats:p>","DOI":"10.3389\/fvets.2026.1780830","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T14:59:37Z","timestamp":1773932377000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Adrenal gland adenoma with myelolipoma in a canine patient: a rare case report and diagnostic insights"],"prefix":"10.3389","volume":"13","author":[{"given":"Ecaterina","family":"Semzenisi","sequence":"first","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca","place":["Cluj-Napoca, Romania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romelia","family":"Pop","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca","place":["Cluj-Napoca, Romania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrada","family":"Negoescu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca","place":["Cluj-Napoca, Romania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Bel","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Surgical Propedeutics, University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca","place":["Cluj-Napoca, Romania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Cre\u021b","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Surgical Propedeutics, University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca","place":["Cluj-Napoca, Romania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Constantin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca","place":["Cluj-Napoca, Romania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudiu-Nicusor","family":"Ionica","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca","place":["Cluj-Napoca, Romania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sorana","family":"Catoi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca","place":["Cluj-Napoca, Romania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahima Mamadou","family":"Sall","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca","place":["Cluj-Napoca, Romania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandu-Flaviu","family":"T\u0103b\u0103ran","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca","place":["Cluj-Napoca, Romania"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","DOI":"10.55418\/9781881041016","volume-title":"Tumors of the Adrenal Glands and Extraadrenal Paraganglia","author":"Lack","year":"2007"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1210\/jcem.82.5.3921","article-title":"Adrenocortical tumors","volume":"82","author":"Latronico","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"ref3","first-page":"665","article-title":"Adrenal myelolipoma","volume":"73","author":"Olsson","year":"1973","journal-title":"Surgery"},{"key":"ref4","first-page":"1112","article-title":"Unusual presentation of splenic myelolipoma in a dog","volume":"47","author":"Al-Rukibat","year":"2006","journal-title":"Can Vet 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mechanisms and diagnostic challenges","volume":"11","author":"Rifici","year":"2021","journal-title":"Diagnostics"}],"updated-by":[{"DOI":"10.3389\/fvets.2026.1853921","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000}}],"container-title":["Frontiers in Veterinary 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