{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T16:20:32Z","timestamp":1778170832279,"version":"3.51.4"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>\n                    Oxidative stress is a critical factor impairing intestinal function and homeostasis in broilers, particularly under dexamethasone (DEX)-induced conditions. Isochlorogenic acid (ICA) and quercetagetin (QG) are natural flavonoids with known antioxidant properties, but their combined effects remain unclear. A total of 270 one-day-old Arbor Acres broilers were randomly assigned to three groups: control, DEX-induced injury, and ICA+QG treatment (100 mg\/kg each). After 21 days of feeding, oxidative stress was induced by intraperitoneal injection of DEX (3 mg\/kg). Serum antioxidant indices, immune parameters, intestinal morphology, and gut microbiota composition were analyzed. Compared with the DEX group, ICA+QG supplementation significantly increased serum superoxide dismutase (SOD) and glutathione (GSH) activities (\n                    <jats:italic>P<\/jats:italic>\n                    &amp;lt; 0.05), while enhancing intestinal antioxidant capacity. Immune-related indicators, including interleukin-1\u03b2 (IL-1\u03b2), interleukin-4 (IL-4), immunoglobulin M (IgM), and complement component 3 (C3), were significantly elevated (\n                    <jats:italic>P<\/jats:italic>\n                    &amp;lt; 0.05). Intestinal morphology was improved, with increased villus height and villus-to-crypt ratio. Moreover, gut microbiota structure was modulated toward a more balanced composition. Combined ICA and QG supplementation alleviates DEX-induced oxidative stress and intestinal damage by enhancing antioxidant defenses, modulating immune responses, and improving intestinal morphology and microbial balance. This strategy may provide a practical nutritional approach to support intestinal function in broilers under stress conditions.\n                  <\/jats:p>","DOI":"10.3389\/fvets.2026.1797403","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T14:46:51Z","timestamp":1777042011000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Combined supplementation with isochlorogenic acid and quercetagetin ameliorates dexamethasone-induced intestinal injury via attenuation of oxidative stress and inflammation"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiaoning","family":"Li","sequence":"first","affiliation":[{"name":"Department of Science and Engineering, Hebei Agricultural University","place":["Cangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yilin","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Science and Engineering, Hebei Agricultural University","place":["Cangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songkang","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Science and Engineering, Hebei Agricultural University","place":["Cangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Hebei Province Plant Source Animal Health Products Technology Innovation Center","place":["Handan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruihui","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Science and Engineering, Hebei Agricultural University","place":["Cangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[{"name":"Office of Development and Planning, Hebei Agricultural University","place":["Baoding, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"65","DOI":"10.38212\/2224-6614.2131","article-title":"Biological activities of low-molecular weight compounds found in foods and plants","volume":"20","author":"Shiratsuchi","year":"2012","journal-title":"J Food Drug Anal"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"144294","DOI":"10.1016\/j.ijbiomac.2025.144294","article-title":"Comprehensive integration strategy combining chemical modification and physical processing for the efficient formulation of cottonseed protein-derived fish feeds with superior animal husbandry potential","volume":"315","author":"Mei","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"106321","DOI":"10.1016\/j.psj.2025.106321","article-title":"Influence of plant-based antioxidant and 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