{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T16:06:48Z","timestamp":1779379608824,"version":"3.53.1"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>Pericardial mesothelioma is a rare and aggressive neoplasm in dogs, typically associated with a poor prognosis and limited treatment options. While chemotherapy is commonly employed, there is limited literature describing successful management without chemotherapeutic intervention. This case report describes a 7-year-old spayed female Pomeranian presenting with acute respiratory distress caused by pericardial effusion. Initial management included pericardiocentesis and medications, but recurrence of the effusion necessitated surgical intervention. Subtotal pericardiectomy was performed, and malignant pericardial mesothelioma was confirmed histopathologically. A thoracic port was implanted postoperatively for ongoing effusion management. The patient remained clinically stable and maintained a good quality of life for 628\u202fdays without chemotherapy, supported by regular monitoring and comprehensive symptomatic care. This case highlights that prolonged survival may be achieved through aggressive effusion control and surgical intervention in dogs with pericardial mesothelioma when systemic chemotherapy is not feasible.<\/jats:p>","DOI":"10.3389\/fvets.2026.1808005","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:30:03Z","timestamp":1779377403000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Clinical course and extended survival in a canine patient with pericardial mesothelioma managed without chemotherapeutic intervention"],"prefix":"10.3389","volume":"13","author":[{"given":"Seol-Gi","family":"Park","sequence":"first","affiliation":[{"name":"Sky Institute of Veterinary Applied Science, Incheon Sky Animal Hospital","place":["Incheon, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seongsoo","family":"Lim","sequence":"additional","affiliation":[{"name":"Veterinary Emergency Medicine, Department of Veterinary Clinical Science, College of Veterinary Medicine, Research Institute for Veterinary Science, Seoul National University","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joungsun","family":"Moon","sequence":"additional","affiliation":[{"name":"Sky Institute of Veterinary Applied Science, Incheon Sky Animal Hospital","place":["Incheon, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"I-se","sequence":"additional","affiliation":[{"name":"Sky Institute of Veterinary Applied Science, Incheon Sky Animal Hospital","place":["Incheon, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taekyu","family":"Chung","sequence":"additional","affiliation":[{"name":"Sky Institute of Veterinary Applied Science, Incheon Sky Animal Hospital","place":["Incheon, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daesik","family":"Kim","sequence":"additional","affiliation":[{"name":"Sky Institute of Veterinary Applied Science, Incheon Sky Animal Hospital","place":["Incheon, Republic of Korea"]},{"name":"Veterinary Emergency Medicine, Department of Veterinary Clinical Science, College of Veterinary Medicine, Research Institute for Veterinary Science, Seoul National University","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1111\/vco.12777","article-title":"Clinical presentation, treatment and outcome of canine malignant mesothelioma: a retrospective study of 34 cases","volume":"20","author":"Moberg","year":"2022","journal-title":"Vet Comp Oncol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1111\/vco.12843","article-title":"Outcome of dogs treated with chemotherapy for mesothelioma: a retrospective clinical study on 40 cases and a literature review","volume":"20","author":"Lajoinie","year":"2022","journal-title":"Vet Comp Oncol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1111\/j.1748-5827.2000.tb03215.x","article-title":"Idiopathic or mesothelioma-related pericardial effusion: clinical findings and survival in 17 dogs studied retrospectively","volume":"41","author":"Stepien","year":"2000","journal-title":"J Small Anim Pract"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/0013-9351(83)90114-7","article-title":"Mesothelioma in pet dogs associated with exposure of their owners to asbestos","volume":"32","author":"Glickman","year":"1983","journal-title":"Environ Res"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.jcpa.2004.03.002","article-title":"Development of pericardial mesothelioma in golden retrievers with a long-term history of idiopathic haemorrhagic pericardial effusion","volume":"131","author":"Machida","year":"2004","journal-title":"J Comp Pathol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1111\/vsu.13475","article-title":"Systematic review of the treatment options for pericardial effusions in dogs","volume":"50","author":"Scheuermann","year":"2021","journal-title":"Vet Surg"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.jvc.2020.09.005","article-title":"Cardiovascular images: constrictive pericarditis and tricavitary effusion in a dog with pericardial mesothelioma","volume":"32","author":"Rivera","year":"2020","journal-title":"J Vet Cardiol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/j.1740-8261.1978.tb01150.x","article-title":"Mesothelioma in the dog: six case reports","volume":"19","author":"Thrall","year":"1978","journal-title":"Vet Radiol Ultrasound"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"170","DOI":"10.17555\/jvc.2024.41.3.170","article-title":"A rare case of canine pericardial malignant mesothelioma: clinicopathologic findings, diagnostic investigations, and clinical course with epirubicin treatment","volume":"41","author":"Min","year":"2024","journal-title":"J Vet Clin"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"S276","DOI":"10.21037\/jtd.2017.10.125","article-title":"The pathological and molecular diagnosis of malignant pleural mesothelioma: a literature review","volume":"10","author":"Al\u00ec","year":"2017","journal-title":"J Thorac Dis"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"830275","DOI":"10.3389\/fvets.2022.830275","article-title":"Focused cardiac ultrasound to detect pre-capillary pulmonary hypertension","volume":"9","author":"Lyssens","year":"2022","journal-title":"Front Vet Sci"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1267359","DOI":"10.3389\/fvets.2023.1267359","article-title":"Chemosensitivity of three patient-derived primary cultures of canine pericardial mesothelioma by single-agent and combination treatment","volume":"10","author":"Nabeta","year":"2023","journal-title":"Front Vet Sci"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"736","DOI":"10.2460\/javma.1997.211.06.736","article-title":"Pericardiectomy in dogs: 22 cases (1978\u20131994)","volume":"211","author":"Kerstetter","year":"1997","journal-title":"J Am Vet Med Assoc"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"194","DOI":"10.2460\/javma.1995.206.02.194","article-title":"Vertebral scale system to measure canine heart size in radiographs","volume":"206","author":"Buchanan","year":"1995","journal-title":"J Am Vet Med Assoc"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"359","DOI":"10.2460\/javma.2000.216.359","article-title":"Bacteria associated with pyothorax of dogs and cats: 98 cases (1989\u20131998)","volume":"216","author":"Walker","year":"2000","journal-title":"J Am Vet Med Assoc"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1111\/j.1939-1676.2004.tb02551.x","article-title":"Allometric scaling of M-mode cardiac measurements in normal adult dogs","volume":"18","author":"Cornell","year":"2004","journal-title":"J Vet Intern Med"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/j.1748-5827.2009.00803.x","article-title":"Can ventricular function be assessed by echocardiography in chronic canine mitral valve disease?","volume":"50","author":"Bonagura","year":"2009","journal-title":"J Small Anim Pract"},{"key":"ref18","volume-title":"Pericardial Mesothelioma with Cardiac Tamponade in a Dog","author":"Turk","year":"1976"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1177\/030098589202900312","article-title":"Canine pericardial mesothelioma","volume":"29","author":"McDonough","year":"1992","journal-title":"Vet Pathol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1002\/dc.21303","article-title":"The sensitivity of cytologic evaluation of pleural fluid in the diagnosis of malignant mesothelioma","volume":"38","author":"Rakha","year":"2010","journal-title":"Diagn Cytopathol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1111\/j.1748-5827.1999.tb03105.x","article-title":"Pericardial mesothelioma in a dog: long-term survival after pericardiectomy in combination with chemotherapy","volume":"40","author":"Closa","year":"1999","journal-title":"J Small Anim Pract"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1111\/j.1740-8261.2011.01883.x","article-title":"CT features of pleural masses and nodules","volume":"53","author":"Reetz","year":"2012","journal-title":"Vet Radiol Ultrasound"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1111\/j.1748-5827.2004.tb00202.x","article-title":"A retrospective study of clinical findings, treatment and outcome in 143 dogs with pericardial effusion","volume":"45","author":"Stafford Johnson","year":"2004","journal-title":"J Small Anim Pract"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.2460\/javma.1998.212.08.1276","article-title":"Analysis of prognostic indicators for dogs with pericardial effusion: 46 cases (1985-1996)","volume":"212","author":"Dunning","year":"1998","journal-title":"J Am Vet Med Assoc"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"980","DOI":"10.2460\/javma.229.6.980","article-title":"Portal site metastasis of invasive mesothelioma after diagnostic thoracoscopy in a dog","volume":"229","author":"Brisson","year":"2006","journal-title":"J Am Vet Med Assoc"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1111\/j.1939-1676.2004.tb02607.x","article-title":"Evaluation of body condition and weight loss in dogs presented to a veterinary oncology service","volume":"18","author":"Michel","year":"2004","journal-title":"J Vet Intern Med"},{"key":"ref27","first-page":"441","article-title":"Critical care nutrition and enteral-assisted feeding","volume":"5","author":"Saker","year":"2010","journal-title":"Small Anim Clin Nutr"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/0167-5273(86)90100-2","article-title":"The use of impedance cardiography in heart failure","volume":"12","author":"Hubbard","year":"1986","journal-title":"Int J Cardiol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"148","DOI":"10.3390\/vetsci10020148","article-title":"Acceptance of a novel, highly palatable, calorically dense, and nutritionally complete diet in dogs with benign and malignant tumors","volume":"10","author":"Anthony","year":"2023","journal-title":"Vet Sci"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"5597","DOI":"10.2147\/CMAR.S261585","article-title":"Cancer cachexia: definition, staging, and emerging treatments","volume":"12","author":"Ni","year":"2020","journal-title":"Cancer Manag Res"}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2026.1808005\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:30:06Z","timestamp":1779377406000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2026.1808005\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,21]]},"references-count":30,"alternative-id":["10.3389\/fvets.2026.1808005"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2026.1808005","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,21]]},"article-number":"1808005"}}