{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T05:25:24Z","timestamp":1787117124453,"version":"build-2736575974"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Vitis vinifera<\/jats:italic>\n                      fruits are common household toxicants and domestic pets are often presented to veterinarians following exposure due to risk of acute kidney injury.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To develop a regular expression\u2013based method for identifying cases of\n                      <jats:italic>Vitis vinifera<\/jats:italic>\n                      fruit ingestion in electronic health records and to use this dataset to compare outcomes between fresh and processed exposures in canines and felines. Secondary aims were to characterize differences in outcome by species, demographics, seasonality, chocolate co-ingestion, and treatment patterns to inform risk stratification and management.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cross-sectional analysis was performed using emergency-care electronic health records from 64 United Kingdom\u2013based private veterinary emergency centers between 2018 and 2024. Iteratively refined Python-based regular expressions were developed and validated to identify suspected or confirmed ingestion from free-text clinical narratives. Cases with confounding toxicities or incomplete records were excluded. Demographic, treatment, and outcome data were extracted. Mortality analyses were conducted by species with correction for multiple comparisons. Decision tree models were developed for canines and felines using stratified training and testing datasets with Bayesian hyperparameter optimization. Model performance was assessed using average precision on held-out data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>31,425 probable canine cases and 1,030 probable feline cases were identified. Processed fruit ingestion was more common than fresh fruit ingestion in both species (canines: 61.6% versus 31.2%; felines: 65.0% versus 31.1%), with seasonal clustering in December (canines: 22.0%; felines: 15.5%). Mortality was 1.3%, significantly higher in felines (11.8%) than in canines (0.9%). Fresh fruit ingestion was associated with higher mortality in both species (canine relative risk 3.47; feline relative risk 3.13). Age was associated with mortality in both species, and increased weight was associated with mortality in canines only. Chocolate co-ingestion was not associated with increased mortality. Treatment differed by species, with emesis more common in canines and intravenous fluids more frequent in felines. Decision tree analysis identified decontamination as the strongest predictor of survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical significance<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Vitis vinifera<\/jats:italic>\n                      ingestion is common in canine emergency presentations and less frequent but more fatal in felines. Fresh fruit ingestion carries higher mortality risk in both species. Gastrointestinal decontamination was the variable most strongly associated with favorable outcomes and supports prompt, species-specific management strategies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fvets.2026.1812885","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T04:41:29Z","timestamp":1787114489000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A multicenter, retrospective, cross-sectional analysis of fresh and processed Vitis vinifera (grape) ingestion in dogs and cats"],"prefix":"10.3389","volume":"13","author":[{"given":"Kara D.","family":"Altman","sequence":"first","affiliation":[{"name":"Emergency and Critical Care Department, Vets Now 24\/7 Pet Emergency Specialty Hospital","place":["Glasgow, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanvi A.","family":"Kamat","sequence":"additional","affiliation":[{"name":"Emergency and Critical Care Department, Vets Now 24\/7 Pet Emergency Specialty Hospital","place":["Glasgow, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Leicester","sequence":"additional","affiliation":[{"name":"Vets Now Limited","place":["Dunfermline, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Fraser","sequence":"additional","affiliation":[{"name":"IVC Evidensia Research United Kingdom, The Chocolate Factory","place":["Bristol, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Singleton","sequence":"additional","affiliation":[{"name":"IVC Evidensia Research United Kingdom, The Chocolate Factory","place":["Bristol, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neus","family":"Elias Santo-Domingo","sequence":"additional","affiliation":[{"name":"Emergency and Critical Care Department, Vets Now 24\/7 Pet Emergency Specialty Hospital","place":["Glasgow, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"26","DOI":"10.3389\/fvets.2016.00026","article-title":"Household food items toxic to dogs and cats","volume":"3","author":"Cortinovis","year":"2016","journal-title":"Front Vet Sci"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.2460\/javma.2001.218.1553","article-title":"Renal failure associated with ingestion of grapes or raisins in dogs","volume":"218","author":"Gwaltney-Brant","year":"2001","journal-title":"J Am Vet Med Assoc"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1111\/j.1534-6935.2004.00114.x","article-title":"Acute renal failure associated with 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