{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T14:55:45Z","timestamp":1781794545681,"version":"3.54.5"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Canine tuberculosis caused by\n                      <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                      is rare and often underdiagnosed. This case report aims to describe the clinical, pathological, and molecular features of a dog with systemic tuberculosis, highlighting its epidemiological relevance within a One Health framework. The specific objective is to characterise a confirmed case of systemic\n                      <jats:italic>M. tuberculosis<\/jats:italic>\n                      infection in a dog, emphasising its unique clinicopathological features, including hypercalcaemia, and documenting an inferred reverse zoonotic transmission with subsequent intra-household zoonotic re-exposure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A 4-year-old male American Staffordshire terrier presented with lethargy, acute vomiting, anorexia, weight loss, generalised muscle atrophy, ataxia, and a history of chronic cough, orthopaedic disease, and dermatopathy treated with corticosteroids. Clinical evaluation revealed hypercalcaemia, oxaluria, proteinuria, and chronic respiratory and dermatological signs. Cytology showed granulomatous inflammation with intracytoplasmic negatively staining bacilli, raising suspicion for mycobacterial infection. Due to clinical deterioration, euthanasia was performed. Gross and histopathology revealed disseminated granulomatous hepatitis, nephritis, prostatitis, splenitis, and pneumonia with extensive caseous necrosis and mineralization. Ziehl\u2013Neelsen staining confirmed intralesional acid-fast bacilli. Molecular diagnostics (PCR\/RFLP, cgMLST) identified\n                      <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                      complex (MTBC), and whole-genome sequencing revealed drug-susceptible\n                      <jats:italic>M. tuberculosis<\/jats:italic>\n                      lineage 4.1.2.1 (Haarlem), unrelated to other local strains. Epidemiological investigation supported reverse zoonotic transmission from an infected owner, with possible secondary transmission to a cohabiting individual.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This case provides a detailed description of systemic canine tuberculosis and highlights hypercalcaemia as a potentially useful clinicopathological clue in veterinary patients with systemic granulomatous disease due to\n                      <jats:italic>M. tuberculosis<\/jats:italic>\n                      . The evidence supports a reverse zoonotic transmission of\n                      <jats:italic>M. tuberculosis<\/jats:italic>\n                      from human to dog, followed by onward zoonotic transmission to a cohabiting person who developed latent infection. This case underscores the importance of integrated cross-species epidemiological surveillance and the need to strengthen diagnostic and tracing protocols for companion animals within a One Health perspective.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fvets.2026.1824722","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T14:37:02Z","timestamp":1781793422000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Epidemiologically inferred reverse zoonosis and intra-household zoonotic re-exposure of Mycobacterium tuberculosis in a domestic dog: a one health alert and the diagnostic potential of hypercalcaemia"],"prefix":"10.3389","volume":"13","author":[{"given":"Elisa","family":"Mazzotta","sequence":"first","affiliation":[{"name":"Istituto Zooprofilattico Sperimentale delle Venezie, SCT3 Padova, Vicenza e Rovigo","place":["Legnaro, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Furlanello","sequence":"additional","affiliation":[{"name":"Veterinary Clinic and Laboratory San Marco, Viale dell\u2019Industria","place":["Veggiano, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alissa","family":"Mazzei","sequence":"additional","affiliation":[{"name":"Veterinary Clinic and Laboratory San Marco, Viale dell\u2019Industria","place":["Veggiano, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Barberio","sequence":"additional","affiliation":[{"name":"Istituto Zooprofilattico Sperimentale delle Venezie, SCT3 Padova, Vicenza e Rovigo","place":["Legnaro, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Martignago","sequence":"additional","affiliation":[{"name":"Istituto Zooprofilattico Sperimentale delle Venezie, SCT3 Padova, Vicenza e Rovigo","place":["Legnaro, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mery","family":"Campalto","sequence":"additional","affiliation":[{"name":"Istituto Zooprofilattico Sperimentale delle Venezie, SCT3 Padova, Vicenza e Rovigo","place":["Legnaro, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Foiani","sequence":"additional","affiliation":[{"name":"Istituto Zooprofilattico Sperimentale delle Venezie, SCT3 Padova, Vicenza e Rovigo","place":["Legnaro, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Moronato","sequence":"additional","affiliation":[{"name":"Servizio di Igiene Urbana Veterinaria AULSS 6 Euganea","place":["Padova, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Battistella","sequence":"additional","affiliation":[{"name":"Dipartimento Di Prevenzione U.O.C. Igiene E Sanit\u00e0 Pubblica AULSS 6 Euganea","place":["Padova, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Santinon","sequence":"additional","affiliation":[{"name":"Dipartimento Di Prevenzione U.O.C. Igiene E Sanit\u00e0 Pubblica AULSS 6 Euganea","place":["Padova, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Sabia","sequence":"additional","affiliation":[{"name":"Dipartimento Di Prevenzione U.O.C. Igiene E Sanit\u00e0 Pubblica AULSS 6 Euganea","place":["Padova, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Carta","sequence":"additional","affiliation":[{"name":"National Reference Centre for Bovine Tuberculosis (NRC-TB), Istituto Zooprofilattico Sperimentale della Lombardia ed Emilia Romagna \u201cBruno Ubertini\u201d","place":["Brescia, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Beatrice","family":"Boniotti","sequence":"additional","affiliation":[{"name":"National Reference Centre for Bovine Tuberculosis (NRC-TB), Istituto Zooprofilattico Sperimentale della Lombardia ed Emilia Romagna \u201cBruno Ubertini\u201d","place":["Brescia, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Di Marco","sequence":"additional","affiliation":[{"name":"Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute","place":["Milano, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Maurizio","family":"Cabibbe","sequence":"additional","affiliation":[{"name":"Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute","place":["Milano, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Maria","family":"Cirillo","sequence":"additional","affiliation":[{"name":"Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute","place":["Milano, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alda","family":"Natale","sequence":"additional","affiliation":[{"name":"Istituto Zooprofilattico Sperimentale delle Venezie, SCT3 Padova, Vicenza e Rovigo","place":["Legnaro, 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