{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:46:48Z","timestamp":1785818808486,"version":"3.56.0"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>Antibiotic use in agriculture is a global driver for antimicrobial resistance (AMR). Dairy farming, one of the largest producers of agricultural waste, represents a critical opportunity for mitigating AMR impacts. We review, synthesize and generalize from results of 10 years of interdisciplinary study of AMR in the waste from a single, medium-sized intensive UK dairy farm and related One Health AMR work. Resistance patterns reflect a combination of (i) short-term stability with (ii) long-term change associated with altered antibiotic use. These dynamics were driven by clonal expansion and contraction characterized by chromosomal carriage of resistance, and co-selection by environmentally stable antimicrobials including copper, zinc and tetracycline, rather than horizontal gene transfer. We outline 10 considerations for study, surveillance and mitigation: (i) the need for long-term longitudinal sampling; (ii) the value of intense focus on representative sites; (iii) inclusion of both Gram-positive and Gram-negative sentinels; (iv) adoption of shared standards for measurement and reporting; (v) use of precise language for AMR hazards to enable appropriate study site selection; (vi) reduction of overall antibiotic use, e.g., through infection control; (vii) continued avoidance of veterinary use of internationally recognized critical human antibiotics; (viii) avoidance of environmentally stable antibiotics such as some tetracyclines; (ix) reduction of co-selection pressure via recovery of metals such as copper and zinc; and (x) mitigation of resistance through storage of slurry without further additions, e.g., through the use of two-tank systems. We propose that these considerations are relevant beyond dairy, applicable in wider livestock, environmental and One Health settings.<\/jats:p>","DOI":"10.3389\/fvets.2026.1829030","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:28:03Z","timestamp":1785817683000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Interdisciplinary insights on selection, surveillance and mitigations of antimicrobial resistance dynamics on a UK dairy farm with relevance to other one health sectors"],"prefix":"10.3389","volume":"13","author":[{"given":"Dov J.","family":"Stekel","sequence":"first","affiliation":[{"name":"School of Biosciences, University of Nottingham, Sutton Bonington Campus","place":["Leicestershire, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Cook","sequence":"additional","affiliation":[{"name":"Quadram Institute Bioscience, Norwich Research Park","place":["Norwich, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delveen R.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, The University of Duhok","place":["Duhok, Iraq"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Jones","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus","place":["Leicestershire, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane T.","family":"Levine","sequence":"additional","affiliation":[{"name":"School of Criminology, Sociology and Social Policy, University of Leicester","place":["Leicester, United Kingdom"]},{"name":"Centre for Social Development in Africa, University of Johannesburg","place":["Johannesburg, South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris D.","family":"Hudson","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus","place":["Leicestershire, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Ulrich","family":"Kreft","sequence":"additional","affiliation":[{"name":"School of Biosciences and Institute of Microbiology and Infection, University of Birmingham","place":["Birmingham, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon L.","family":"Hobman","sequence":"additional","affiliation":[{"name":"School of Biosciences, University of Nottingham, Sutton Bonington Campus","place":["Leicestershire, United 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