{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T14:55:19Z","timestamp":1781794519680,"version":"3.54.5"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study aimed to investigate the effects of yeast-derived nucleotides on growth performance, serum biochemical indices, apparent digestibility, growth hormones, immune function, and intestinal microbiota in weaned kittens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixteen 4-month-old healthy weaned kittens were randomly assigned into two groups with 8 kittens each. The control group (CON) was fed a basal dry food diet, the experimental group (TREAT) was fed the basal dry food diet supplemented with 0.03% yeast-derived nucleotides.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 42 days of feeding, the levels of total protein (TP), albumin (ALB), globulin (GLB), creatinine (Crea) and aspartate aminotransferase (AST) were significantly increased (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.05) in TREAT group. The apparent digestibility of dry matter (DM), organic matter (OM), and crude protein (CP) in the TREAT group was significantly higher than that in the CON group (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.05). The serum concentrations of growth hormone (GH), insulin-like growth factor-1 (IGF-1), and immunoglobulin G (IgG) in the TREAT group were significantly increased (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.01) and were significantly higher than CON group (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.01). The concentrations of immunoglobulin A (IgA) and immunoglobulin M (IgM) were significantly higher than CON group (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.01). At the genus level, compared with the CON group, the relative abundances of Sellimonas and\n                      <jats:italic>Acutalibacter<\/jats:italic>\n                      in the TREAT group were significantly increased (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.05), while those of\n                      <jats:italic>Lachnospiraceae_NK4A136_group<\/jats:italic>\n                      and\n                      <jats:italic>Sarcina<\/jats:italic>\n                      were significantly decreased (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>In conclusion, dietary supplementation with 0.03% yeast-derived nucleotides improved the nutrient utilization efficiency and presents a potential to maintain relatively higher humoral immunity and improve health condition of weaned kittens.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fvets.2026.1843322","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T14:26:48Z","timestamp":1781792808000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of dietary nucleotide supplementation on growth performance, immune function, and intestinal microbiota in weaned kittens"],"prefix":"10.3389","volume":"13","author":[{"given":"Can","family":"Zhang","sequence":"first","affiliation":[{"name":"China Pet Foods Pet Nutrition and Health Research Institute, China Pet Technology (Yantai) Co., Ltd.","place":["Yantai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lupeng","family":"Qin","sequence":"additional","affiliation":[{"name":"China Pet Foods Pet Nutrition and Health Research Institute, China Pet Technology (Yantai) Co., Ltd.","place":["Yantai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanzhao","family":"Zhao","sequence":"additional","affiliation":[{"name":"China Pet Foods Pet Nutrition and Health Research Institute, China Pet Technology (Yantai) Co., Ltd.","place":["Yantai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqi","family":"Yuan","sequence":"additional","affiliation":[{"name":"China Pet Foods Pet Nutrition and Health Research Institute, China Pet Technology (Yantai) Co., Ltd.","place":["Yantai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingtong","family":"Kang","sequence":"additional","affiliation":[{"name":"China Pet Foods Pet Nutrition and Health Research Institute, China Pet Technology (Yantai) Co., Ltd.","place":["Yantai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[{"name":"China Pet Foods Pet Nutrition and Health Research Institute, China Pet Technology (Yantai) Co., Ltd.","place":["Yantai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Zhang","sequence":"additional","affiliation":[{"name":"China Pet Foods Pet Nutrition and Health Research Institute, China Pet Technology (Yantai) Co., Ltd.","place":["Yantai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijian","family":"Nie","sequence":"additional","affiliation":[{"name":"China Pet Foods Pet Nutrition and Health Research Institute, China Pet Technology (Yantai) Co., Ltd.","place":["Yantai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"ref1","volume-title":"Nutrient Requirements of Dogs and Cats","year":"2006"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1093\/jn\/114.4.753","article-title":"Absorption and metabolism of adenine, 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