{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T05:09:24Z","timestamp":1779426564759,"version":"3.53.1"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study evaluated the effects of dietary supplementation with Jiang-flavor Baijiu distiller's grains yeast culture (JBGC) on immune performance and intestinal health in geese.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 512 one-day-old Magang geese were randomly assigned to four dietary treatments 0% (control), 2%, 6%, or 10% JBGC with eight replicates per treatment and 16 birds per replicate, over a 70-day experimental period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      JBGC supplementation exhibited dose- and time-dependent effects on antioxidant and inflammatory responses. Compared with the control, 10% JBGC significantly reduced serum glutathione peroxidase activity at day 70 and total antioxidant capacity at day 28 (\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.05), whereas both 6% and 10% JBGC increased hepatic total superoxide dismutase activity (\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.05). Regarding inflammatory markers, 10% JBGC lowered serum IL-1\u03b2 at day 70 (\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.05), and all JBGC-supplemented groups (2%, 6%, and 10%) showed significantly lower IL-8 levels than the control during the later phase (\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.05). Additionally, 6 and 10% JBGC elevated the anti-inflammatory cytokine IL-10 at day 70 (\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.05). JBGC also improved intestinal morphology and barrier function: 6 and 10% JBGC increased ileal villus height (\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.05); 10% JBGC enhanced duodenal length and weight, jejunal weight, and total small intestinal weight; and 6% JBGC upregulated the protein expression of occludin and claudin?5 (\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.05). Although cecal microbial alpha diversity did not differ significantly, several beneficial bacterial genera showed increasing trends.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These findings indicate that JBGC can positively modulate immune and intestinal health in geese by influencing antioxidant status, inflammatory cytokine profiles, intestinal morphology, and barrier integrity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fvets.2026.1846477","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T04:44:36Z","timestamp":1779425076000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Yeast culture derived from Jiang-flavor Baijiu distiller's grains enhances immune function and gut health in geese"],"prefix":"10.3389","volume":"13","author":[{"given":"Pan","family":"Tao","sequence":"first","affiliation":[{"name":"Guangdong Engineering Technology Research Center of Biosafety and Intelligent Control for Aquatic Animals Diseases, Zhongkai University of Agriculture and Engineering","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Road Biological Environmental Protection Technology Co., Ltd.","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-jie","family":"Li","sequence":"additional","affiliation":[{"name":"Waterfowl Healthy Breeding Engineering Research Center of Guangdong, Zhongkai University of Agriculture and Engineering","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Waterfowl Healthy Breeding Engineering Research Center of Guangdong, Zhongkai University of Agriculture and Engineering","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-ming","family":"Zuo","sequence":"additional","affiliation":[{"name":"Waterfowl Healthy Breeding Engineering Research Center of Guangdong, Zhongkai University of Agriculture and Engineering","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-hong","family":"Peng","sequence":"additional","affiliation":[{"name":"Waterfowl Healthy Breeding Engineering Research Center of Guangdong, Zhongkai University of Agriculture and Engineering","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-kuan","family":"Ji","sequence":"additional","affiliation":[{"name":"Road Biological Environmental Protection Technology Co., Ltd.","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-tao","family":"Lv","sequence":"additional","affiliation":[{"name":"Waterfowl Healthy Breeding Engineering Research Center of Guangdong, Zhongkai University of Agriculture and Engineering","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-mao","family":"Huang","sequence":"additional","affiliation":[{"name":"Waterfowl Healthy Breeding Engineering Research Center of Guangdong, Zhongkai University of Agriculture and Engineering","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"102981","DOI":"10.1016\/j.psj.2023.102981","article-title":"Distillers dried grains with soluble and enzyme inclusion in the diet effects broilers performance, intestinal health, and microbiota 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