{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:21:43Z","timestamp":1792758103803,"version":"4.5.0"},"reference-count":227,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>Mycotoxins, secondary toxic metabolites produced by filamentous fungi, pose significant health risks through contamination of food commodities such as grains. Major mycotoxins, including T-2 toxin, aflatoxins, and ochratoxin, are associated with a range of adverse health effects, particularly gastrointestinal disorders and hepatotoxicity. Increasing attention has been directed toward the gut\u2013liver axis, which plays a critical role in mediating the systemic impact of these toxins, alongside growing interest in natural products as potential therapeutic agents. Natural compounds, including probiotics and antioxidants, have demonstrated the ability to mitigate mycotoxin toxicity through multiple mechanisms, such as toxin binding, inhibition of intestinal absorption, and biotransformation, mediated by pathways including Nrf2\u2013ARE signaling and modulation of antioxidant enzyme activities. This review highlights the complex molecular mechanisms and signaling networks involved in mycotoxin toxicity, with particular emphasis on the gut\u2013liver\u2013hypothalamus axis. Disruption of gut microbiota homeostasis is recognized as a key initial event that compromises intestinal barrier integrity, facilitating toxin translocation to the liver and subsequent effects on hepatic function and hypothalamic hormonal regulation. Emerging evidence supports the potential of natural products as promising therapeutic strategies for restoring the balance of the gut\u2013liver\u2013hypothalamus axis and improving overall health outcomes; however, further research is needed to better elucidate their mechanisms of action and expand their application in the prevention and management of mycotoxin-related diseases.<\/jats:p>","DOI":"10.3389\/fvets.2026.1852579","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:22:53Z","timestamp":1780492973000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Gut\u2013liver\u2013hypothalamus axis dysfunction in mycotoxin toxicity: mechanisms and protective roles of natural compounds"],"prefix":"10.3389","volume":"13","author":[{"given":"Wael","family":"Ennab","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Animal Genetic Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University","place":["Yangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Tharwat","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Qassim University","place":["Buraidah, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdallah A.","family":"Mousa","sequence":"additional","affiliation":[{"name":"Animal Production Department, Faculty of Agriculture, Benha University","place":["Banha, Egypt"]},{"name":"Laboratory of Gastrointestinal Microbiology, College of Animal Science and Technology, Nanjing Agricultural University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Animal Genetic Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University","place":["Yangzhou, China"]},{"name":"International Joint Research Laboratory in Universities of Jiangsu Province of China for Domestic Animal Germplasm Resources and Genetic Improvement","place":["Yangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghaid J.","family":"Al-Rabadi","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, Mutah University","place":["Karak, Jordan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baiome Abdelmaguid","family":"Baiome","sequence":"additional","affiliation":[{"name":"Parasitology and Animal Diseases Institute, National Research Centre","place":["Giza, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahad A.","family":"Alshanbari","sequence":"additional","affiliation":[{"name":"Department of Medical Biosciences, College of Veterinary Medicine, Qassim University","place":["Buraidah, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demin","family":"Cai","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Animal Genetic Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University","place":["Yangzhou, China"]},{"name":"Faculty of Agriculture, Mutah University","place":["Karak, Jordan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.jfutfo.2022.03.002","article-title":"An overview on the major mycotoxins in food products: characteristics, toxicity, and analysis","volume":"2","author":"El-Sayed","year":"2022","journal-title":"J Future Foods"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/978-1-4471-5553-9_6","volume-title":"An Introduction to Toxicology","author":"Burcham","year":"2014"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"155","DOI":"10.2174\/2212798410901020155","article-title":"Chemical and biological approaches for mycotoxin control: a review","volume":"1","author":"Edlayne","year":"2009","journal-title":"Recent Pat Food Nutr Agric"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"2773","DOI":"10.1080\/10408398.2019.1658570","article-title":"Worldwide contamination of food-crops with mycotoxins: validity of the widely cited \u2018FAO estimate\u2019of 25%","volume":"60","author":"Eskola","year":"2020","journal-title":"Crit Rev Food Sci Nutr"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"137","DOI":"10.3390\/foods9020137","article-title":"Advances in occurrence, importance, and mycotoxin control strategies: prevention and detoxification in foods","volume":"9","author":"Agriopoulou","year":"2020","journal-title":"Foods."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.3390\/foods10061279","article-title":"Mycotoxins affecting animals, foods, humans, and plants: types, occurrence, toxicities, action mechanisms, prevention, and detoxification strategies\u2014a revisit","volume":"10","author":"Awuchi","year":"2021","journal-title":"Foods"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"2362","DOI":"10.3390\/molecules24132362","article-title":"Enzymes for detoxification of various mycotoxins: origins and mechanisms of catalytic action","volume":"24","author":"Lyagin","year":"2019","journal-title":"Molecules"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"72","DOI":"10.17221\/3302-cjfs","article-title":"Antimutagenic effect of curcumin and its effect on the immune response in mice","volume":"24","author":"\u0160mer\u00e1k","year":"2006","journal-title":"Czech J Food Sci"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"357","DOI":"10.2174\/1568011024606370","article-title":"The molecular mechanisms for the antitumorigenic effect of curcumin","volume":"2","author":"Leu","year":"2002","journal-title":"Curr Med Chem Anti Cancer Agents"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"761608","DOI":"10.1155\/2014\/761608","article-title":"Curcumin: a potential candidate in prevention of cancer via modulation of molecular pathways","volume":"2014","author":"Rahmani","year":"2014","journal-title":"Biomed Res Int"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"283","DOI":"10.3390\/livers2040023","article-title":"Role of oxidative stress in liver disorders","volume":"2","author":"de la Conde Rosa","year":"2022","journal-title":"Liver"},{"key":"ref12","first-page":"189","volume-title":"Oral Bioavailability and Drug Delivery: From Basics to Advanced Concepts and Applications","author":"Kurian","year":"2024"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3389\/fonc.2012.00057","article-title":"Homeostatic imbalance and colon cancer: the dynamic epigenetic interplay of inflammation, environmental toxins, and chemopreventive plant compounds","volume":"2","author":"Sokolosky","year":"2012","journal-title":"Front Oncol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"4807","DOI":"10.3390\/ijms22094807","article-title":"Role of endocrine-disrupting chemicals in the pathogenesis of non-alcoholic fatty liver disease: a comprehensive review","volume":"22","author":"Cano","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1093\/carcin\/18.9.1729","article-title":"Mechanism of action of dietary chemoprotective agents in rat liver: induction of phase I and II drug metabolizing enzymes and aflatoxin B1 metabolism","volume":"18","author":"Manson","year":"1997","journal-title":"Carcinogenesis"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"500","DOI":"10.2174\/0929867321666140916123022","article-title":"Biotransformation of endocrine disrupting compounds by selected phase I and phase II enzymes\u2013formation of estrogenic and chemically reactive metabolites by cytochromes P450 and sulfotransferases","volume":"22","author":"Reinen","year":"2015","journal-title":"Curr Med Chem"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1007\/s10482-020-01474-7","article-title":"Human gut microbiota\/microbiome in health and diseases: a review","volume":"113","author":"Gomaa","year":"2020","journal-title":"Antonie Van Leeuwenhoek"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1517\/17425255.2.6.875","article-title":"Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction","volume":"2","author":"Martignoni","year":"2006","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/B978-0-12-407160-5.00014-2","volume-title":"Sturkie's avian Physiology","author":"Denbow","year":"2015"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1080\/00498250010021684","article-title":"Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man","volume":"30","author":"Bogaards","year":"2000","journal-title":"Xenobiotica"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"16037","DOI":"10.1038\/s41598-023-43123-9","article-title":"Cecal microbiota composition differs under normal and high ambient temperatures in genetically distinct chicken lines","volume":"13","author":"Campos","year":"2023","journal-title":"Sci Rep"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1002\/pros.24223","article-title":"The Firmicutes\/Bacteroidetes ratio of the human gut microbiota is associated with prostate enlargement","volume":"81","author":"Takezawa","year":"2021","journal-title":"Prostate"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1186\/s12967-018-1678-1","article-title":"Is it possible to overcome issues of external validity in preclinical animal research? Why most animal models are bound to fail","volume":"16","author":"Pound","year":"2018","journal-title":"J Transl Med"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1038\/s41575-023-00771-6","article-title":"Gut\u2013liver axis: barriers and functional circuits","volume":"20","author":"Pabst","year":"2023","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"507","DOI":"10.2174\/138920011795713698","article-title":"Xenobiotic metabolizing cytochrome P450 in pig, a promising animal model","volume":"12","author":"Puccinelli","year":"2011","journal-title":"Curr Drug Metab"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"586","DOI":"10.3390\/toxins13080586","article-title":"Mycotoxin biomarkers in pigs\u2014current state of knowledge and analytics","volume":"13","author":"Tkaczyk","year":"2021","journal-title":"Toxins"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"e4","DOI":"10.4081\/xeno.2011.e4","article-title":"Enzymatic activity in Turkey, duck, quail and chicken liver microsomes against four human cytochrome P450 prototype substrates and aflatoxin B1","volume":"1","author":"Murcia","year":"2011","journal-title":"J Xenobiot"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"920147","DOI":"10.3389\/fimmu.2022.920147","article-title":"Combined toxicity evaluation of ochratoxin A and aflatoxin B1 on kidney and liver injury, immune inflammation, and gut microbiota alteration through pair-feeding pullet model","volume":"13","author":"Qing","year":"2022","journal-title":"Front Immunol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3390\/toxins11010055","article-title":"Differential transcriptome responses to aflatoxin B1 in the cecal tonsil of susceptible and resistant turkeys","volume":"11","author":"Reed","year":"2019","journal-title":"Toxins"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3389\/fcimb.2018.00060","article-title":"Mycotoxin: its impact on gut health and microbiota","volume":"8","author":"Liew","year":"2018","journal-title":"Front Cell Infect Microbiol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"139","DOI":"10.3390\/microorganisms8010139","article-title":"Dietary factors as triggers of low-grade chronic intestinal inflammation in poultry","volume":"8","author":"Cardoso Dal Pont","year":"2020","journal-title":"Microorganisms"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3390\/toxins16040167","article-title":"Endotoxin translocation is increased in broiler chickens fed a fusarium mycotoxin-contaminated diet","volume":"16","author":"Reisinger","year":"2024","journal-title":"Toxins"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/s1594-5804(09)60016-4","article-title":"Intestinal microbiota and its functions","volume":"3","author":"Montalto","year":"2009","journal-title":"Dig Liver Dis Suppl"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"9","DOI":"10.12688\/f1000research.20510.1","article-title":"All disease begins in the (leaky) gut: role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases","volume":"9","author":"Fasano","year":"2020","journal-title":"F1000Res"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"e0218384","DOI":"10.1371\/journal.pone.0218384","article-title":"Antibiotics induced intestinal tight junction barrier dysfunction is associated with microbiota dysbiosis, activated NLRP3 inflammasome and autophagy","volume":"14","author":"Feng","year":"2019","journal-title":"PLoS One"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"2896","DOI":"10.3390\/ijms23052896","article-title":"Overview of the importance of biotics in gut barrier integrity","volume":"23","author":"Kocot","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"27","DOI":"10.4291\/wjgp.v3.i1.27","article-title":"Host-microbial interactions and regulation of intestinal epithelial barrier function: from physiology to pathology","volume":"3","author":"Yu","year":"2012","journal-title":"World J Gastrointest Pathophysiol"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"114985","DOI":"10.1016\/j.biopha.2023.114985","article-title":"Immunological mechanisms of inflammatory diseases caused by gut microbiota dysbiosis: a review","volume":"164","author":"Chu","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"G367","DOI":"10.1152\/ajpgi.00173.2003","article-title":"TNF-\u03b1-induced increase in intestinal epithelial tight junction permeability requires NF-\u03baB activation","volume":"286","author":"Ma","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"e0179586","DOI":"10.1371\/journal.pone.0179586","article-title":"Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway","volume":"12","author":"Yan","year":"2017","journal-title":"PLoS One"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1002\/hep4.1268","article-title":"Regulatory T cells restrict permeability to bacterial antigen translocation and preserve short-chain fatty acids in experimental cirrhosis","volume":"2","author":"Juanola","year":"2018","journal-title":"Hepatol Communic"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"5679","DOI":"10.1128\/IAI.69.9.5679-5688.2001","article-title":"Enteropathogenic Escherichia coli activates ezrin, which participates in disruption of tight junction barrier function","volume":"69","author":"Simonovic","year":"2001","journal-title":"Infect Immun"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1159\/000085686","article-title":"Oxidative stress and reactive oxygen species","volume":"149","author":"Galli","year":"2005","journal-title":"Cardiovasc Disorders Hemodial"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-4614-5167-9_1","volume-title":"Liver Anesthesiology and Critical Care Medicine","author":"Mulaikal","year":"2012"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.jhep.2019.10.003","article-title":"The gut-liver axis in liver disease: pathophysiological basis for therapy","volume":"72","author":"Albillos","year":"2020","journal-title":"J Hepatol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"114422","DOI":"10.1016\/j.addr.2022.114422","article-title":"Understanding the bidirectional interactions between two-dimensional materials, microorganisms, and the immune system","volume":"188","author":"Peng","year":"2022","journal-title":"Adv Drug Deliv Rev"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"4607","DOI":"10.1073\/pnas.100009210","article-title":"Epithelial crosstalk at the microbiota\u2013mucosal interface","volume":"108","author":"Wells","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.3945\/an.116.013219","article-title":"Impact of dietary fibers on nutrient management and detoxification organs: gut, liver, and kidneys","volume":"7","author":"Kieffer","year":"2016","journal-title":"Adv Nutr"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"117177","DOI":"10.1016\/j.biopha.2024.117177","article-title":"The interplay between cytokines, inflammation, and antioxidants: mechanistic insights and therapeutic potentials of various antioxidants and anti-cytokine compounds","volume":"178","author":"Bhol","year":"2024","journal-title":"Biomed Pharmacother"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1007\/s00018-019-03011-w","article-title":"The links between the gut microbiome and non-alcoholic fatty liver disease (NAFLD)","volume":"76","author":"Safari","year":"2019","journal-title":"Cell Mol Life Sci"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"11597","DOI":"10.3748\/wjg.v21.i41.11597","article-title":"Gut microbiota and host metabolism in liver cirrhosis","volume":"21","author":"Usami","year":"2015","journal-title":"World J Gastroenterol"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1097\/CM9.0000000000000696","article-title":"Gut microbiota and metabolic syndrome","volume":"133","author":"Wang","year":"2020","journal-title":"Chin Med J"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.1136\/gutjnl-2016-312729","article-title":"Gut microbiome and liver diseases","volume":"65","author":"Tilg","year":"2016","journal-title":"Gut"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1053\/he.2000.5634","article-title":"Kupffer cell activation by lipopolysaccharide in rats: role for lipopolysaccharide binding protein and toll-like receptor 4","volume":"31","author":"Su","year":"2000","journal-title":"Hepatology"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"4527","DOI":"10.2147\/JIR.S430730","article-title":"The role of inflammation in Cholestatic liver injury","volume":"16","author":"Chen","year":"2023","journal-title":"J Inflamm Res"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.4172\/2161-0495.S4-001","article-title":"Clinical biochemistry of hepatotoxicity","volume":"4","author":"Singh","year":"2011","journal-title":"J Clinic Toxicol S"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"4112","DOI":"10.1111\/jam.15504","article-title":"Balancing reactive oxygen species generation by rebooting gut microbiota","volume":"132","author":"Singh","year":"2022","journal-title":"J Appl Microbiol"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"3159","DOI":"10.3390\/molecules27103159","article-title":"Oxidative stress, genomic integrity, and liver diseases","volume":"27","author":"Sadasivam","year":"2022","journal-title":"Molecules"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S0074-7696(06)60002-8","article-title":"Molecular mechanism of phase I and phase II drug-metabolizing enzymes: implications for detoxification","volume":"260","author":"Iyanagi","year":"2007","journal-title":"Int Rev Cytol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/978-1-4419-7107-4_11","volume-title":"Molecular Pathology of liver Diseases","author":"Apte","year":"2011"},{"key":"ref61","first-page":"1035","volume-title":"Execution of Apoptosis: Converging or Diverging Pathways?","author":"Nicotera","year":"1999"},{"key":"ref62","first-page":"716","author":"Malhotra","year":"2007"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1080\/03602530500205135","article-title":"The endoplasmic reticulum in xenobiotic toxicity","volume":"37","author":"Cribb","year":"2005","journal-title":"Drug Metab Rev"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.3390\/antiox10111824","article-title":"Mitochondrial management of reactive oxygen species","volume":"10","author":"Napolitano","year":"2021","journal-title":"Antioxidants"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/nri.2017.11","article-title":"Liver macrophages in tissue homeostasis and disease","volume":"17","author":"Krenkel","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"661182","DOI":"10.3389\/fimmu.2021.661182","article-title":"Macrophages in chronic liver failure: diversity, plasticity and therapeutic targeting","volume":"12","author":"Singanayagam","year":"2021","journal-title":"Front Immunol"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3727\/105221618X15156018385515","article-title":"Bile acid metabolism in liver pathobiology","volume":"18","author":"Chiang","year":"2018","journal-title":"Gene Expr"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/BF03033301","article-title":"The role of signaling molecules in reward-related incentive learning","volume":"6","author":"Beninger","year":"2004","journal-title":"Neurotox Res"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/s12041-011-0107-5","article-title":"Eight paths of ERK1\/2 signalling pathway regulating hepatocyte proliferation in rat liver regeneration","volume":"90","author":"Li","year":"2011","journal-title":"J Genet"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"C189","DOI":"10.1152\/ajpcell.00347.2009","article-title":"The dual-specificity MAP kinase phosphatases: critical roles in development and cancer","volume":"299","author":"Bermudez","year":"2010","journal-title":"Am J Phys Cell Phys"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.taap.2009.03.021","article-title":"Activation of ERK and JNK signaling pathways by mycotoxin citrinin in human cells","volume":"237","author":"Chang","year":"2009","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref72","first-page":"378","author":"Czaja","year":"2007"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"4758","DOI":"10.1111\/1541-4337.13242","article-title":"Insights into the intestinal toxicity of foodborne mycotoxins through gut microbiota: A comprehensive review","volume":"22","author":"Ruan","year":"2023","journal-title":"Compr Rev Food Sci Food Saf"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"970","DOI":"10.3109\/13880209.2011.558515","article-title":"Recent advances in herbal medicine for treatment of liver diseases","volume":"49","author":"Ghosh","year":"2011","journal-title":"Pharm Biol"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1080\/03602532.2016.1197239","article-title":"Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters","volume":"48","author":"Bai","year":"2016","journal-title":"Drug Metab Rev"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.bcp.2011.12.006","article-title":"Ah receptor-and Nrf2-gene battery members: modulators of quinone-mediated oxidative and endoplasmic reticulum stress","volume":"83","author":"Bock","year":"2012","journal-title":"Biochem Pharmacol"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.taap.2010.01.013","article-title":"Nrf2 the rescue: effects of the antioxidative\/electrophilic response on the liver","volume":"244","author":"Klaassen","year":"2010","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"1429836","DOI":"10.3389\/fimmu.2024.1429836","article-title":"Dual role of Nrf2 signaling in hepatocellular carcinoma: promoting development, immune evasion, and therapeutic challenges","volume":"15","author":"Gan","year":"2024","journal-title":"Front Immunol"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"481","DOI":"10.3390\/cancers10120481","article-title":"Dysregulation of Nrf2 in hepatocellular carcinoma: role in cancer progression and chemoresistance","volume":"10","author":"Raghunath","year":"2018","journal-title":"Cancer"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/j.1600-0447.1988.tb08556.x","article-title":"Implications of altered limbic-hypothalamicpituitary-adrenocortical (LHPA)-function for neurobiology of depression","volume":"77","author":"Holsboer","year":"1988","journal-title":"Acta Psychiatr Scand"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"T25","DOI":"10.1530\/JOE-15-0157","article-title":"The structure of the neuroendocrine hypothalamus: the neuroanatomical legacy of Geoffrey Harris","volume":"226","author":"Watts","year":"2015","journal-title":"J Endocrinol"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/978-981-16-9016-7_4","volume-title":"Emerging Concepts in Endocrine Structure and Functions","author":"Al-Suhaimi","year":"2022"},{"key":"ref83","first-page":"369","volume-title":"Textbook of Veterinary Physiology","author":"Baa","year":"2023"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.toxicon.2016.04.036","article-title":"Anorexic action of deoxynivalenol in hypothalamus and intestine","volume":"118","author":"Tominaga","year":"2016","journal-title":"Toxicon"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1002\/jat.3652","article-title":"Mycotoxin zearalenone induced gonadal impairment and altered gene expression in the hypothalamic\u2013pituitary\u2013gonadal axis of adult female zebrafish (Danio rerio)","volume":"38","author":"Muthulakshmi","year":"2018","journal-title":"J Appl Toxicol"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.mce.2016.08.012","article-title":"Prepubertal exposure to an oestrogenic mycotoxin zearalenone induces central precocious puberty in immature female rats through the mechanism of premature activation of hypothalamic kisspeptin-GPR54 signaling","volume":"437","author":"Yang","year":"2016","journal-title":"Mol Cell Endocrinol"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.fct.2014.11.025","article-title":"Toxicity of aflatoxin B1 towards the vitamin D receptor (VDR)","volume":"76","author":"Costanzo","year":"2015","journal-title":"Food Chem Toxicol"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1177\/0960327116629529","article-title":"Prepubertal exposure to T-2 toxin advances pubertal onset and development in female rats via promoting the onset of hypothalamic\u2013pituitary\u2013gonadal axis function","volume":"35","author":"Yang","year":"2016","journal-title":"Hum Exp Toxicol"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.tifs.2019.11.022","article-title":"Interactions between probiotics and pathogenic microorganisms in hosts and foods: a review","volume":"95","author":"Khaneghah","year":"2020","journal-title":"Trends Food Sci Technol"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"466","DOI":"10.4315\/0362-028X-61.4.466","article-title":"Physicochemical alterations enhance the ability of dairy strains of lactic acid bacteria to remove aflatoxin from contaminated media","volume":"61","author":"El-Nezami","year":"1998","journal-title":"J Food Prot"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"2152","DOI":"10.3168\/jds.S0022-0302(01)74660-7","article-title":"Aflatoxin B1 binding by dairy strains of lactic acid bacteria and bifidobacteria","volume":"84","author":"Peltonen","year":"2001","journal-title":"J Dairy Sci"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1080\/19440049.2011.605771","article-title":"Saccharomyces cerevisiae strains retain their viability and aflatoxin B1 binding ability under gastrointestinal conditions and improve ruminal fermentation","volume":"28","author":"Dogi","year":"2011","journal-title":"Food Addit Contam Part A Chem Anal Control Expo Risk Assess"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/03602530802563850","article-title":"Biological degradation of aflatoxins","volume":"41","author":"Wu","year":"2009","journal-title":"Drug Metab Rev"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"164","DOI":"10.4161\/gmic.1.3.12127","article-title":"Safety assessment of probiotics for human use","volume":"1","author":"Sanders","year":"2010","journal-title":"Gut Microbes"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"143","DOI":"10.3920\/BM2016.0140","article-title":"A review of dose-responses of probiotics in human studies","volume":"8","author":"Ouwehand","year":"2017","journal-title":"Benef Microbes"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"S129","DOI":"10.1093\/cid\/civ085","article-title":"Risk and safety of probiotics","volume":"60","author":"Doron","year":"2015","journal-title":"Clinic Infect Dis"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.biopha.2018.12.104","article-title":"Probiotic supplements might not be universally-effective and safe: A review","volume":"111","author":"Kothari","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"2534","DOI":"10.3390\/ijms20102534","article-title":"Health benefits of heat-killed (Tyndallized) probiotics: an overview","volume":"20","author":"Piqu\u00e9","year":"2019","journal-title":"Int J Mol Sci"},{"key":"ref99","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.tifs.2021.01.039","article-title":"Novel approaches for co-encapsulation of probiotic bacteria with bioactive compounds, their health benefits and functional food product development: A review","volume":"109","author":"Misra","year":"2021","journal-title":"Trends Food Sci Technol"},{"key":"ref100","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.ijfoodmicro.2015.04.042","article-title":"Potential of lactic acid bacteria in aflatoxin risk mitigation","volume":"207","author":"Ahlberg","year":"2015","journal-title":"Int J Food Microbiol"},{"key":"ref101","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1111\/jgh.15970","article-title":"Short-chain fatty acids affect the development of inflammatory bowel disease through intestinal barrier, immunology, and microbiota: A promising therapy?","volume":"37","author":"Peng","year":"2022","journal-title":"J Gastroenterol Hepatol"},{"key":"ref102","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3389\/fimmu.2019.00277","article-title":"Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases","volume":"10","author":"Parada Venegas","year":"2019","journal-title":"Front Immunol"},{"key":"ref103","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.aninu.2021.09.012","article-title":"The interaction among gut microbes, the intestinal barrier and short chain fatty acids","volume":"9","author":"Ma","year":"2022","journal-title":"Anim Nutr"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"6505","DOI":"10.1080\/10408398.2021.1902263","article-title":"Therapeutic modulation methods of gut microbiota and gut-liver axis","volume":"62","author":"Beyaz Co\u015fkun","year":"2022","journal-title":"Crit Rev Food Sci Nutr"},{"key":"ref105","doi-asserted-by":"publisher","first-page":"2617","DOI":"10.3390\/cells11162617","article-title":"A multi-strain probiotic formulation improves intestinal barrier function by the modulation of tight and adherent junction proteins","volume":"11","author":"di Vito","year":"2022","journal-title":"Cells"},{"key":"ref106","doi-asserted-by":"publisher","first-page":"13475","DOI":"10.3390\/ijms222413475","article-title":"Molecular and cellular mechanisms influenced by postbiotics","volume":"22","author":"Jastrz\u0105b","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref107","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1515\/fv-2016-0003","article-title":"Intestinal mucus layer and mucins (a review)","volume":"60","author":"Tarabova","year":"2016","journal-title":"Folia Vet"},{"key":"ref108","doi-asserted-by":"publisher","first-page":"578386","DOI":"10.3389\/fimmu.2021.578386","article-title":"Anti-inflammatory and immunomodulatory effects of probiotics in gut inflammation: a door to the body","volume":"12","author":"Cristofori","year":"2021","journal-title":"Front Immunol"},{"key":"ref109","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1159\/000496426","article-title":"Beneficial effects of probiotic consumption on the immune system","volume":"74","author":"Maldonado Galdeano","year":"2019","journal-title":"Ann Nutr Metab"},{"key":"ref110","doi-asserted-by":"publisher","first-page":"107087","DOI":"10.1016\/j.intimp.2020.107087","article-title":"Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets","volume":"89","author":"Kumar","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"ref111","doi-asserted-by":"publisher","first-page":"H839","DOI":"10.1152\/ajpheart.00278.2021","article-title":"Lactobacillus plantarum probiotic induces Nrf2-mediated antioxidant signaling and eNOS expression resulting in improvement of myocardial diastolic function","volume":"321","author":"Aboulgheit","year":"2021","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref112","doi-asserted-by":"publisher","first-page":"1155306","DOI":"10.3389\/fnut.2023.1155306","article-title":"Effects of probiotics on non-alcoholic fatty liver disease: a review of human clinical trials","volume":"10","author":"Cao","year":"2023","journal-title":"Front Nutr"},{"key":"ref113","doi-asserted-by":"publisher","first-page":"1362694","DOI":"10.3389\/fnut.2024.1362694","article-title":"Probiotic supplementation for 24\u202fweeks in patients with non-alcoholic steatohepatitis: the PROBILIVER randomized clinical trial","volume":"11","author":"Silva-Sperb","year":"2024","journal-title":"Front Nutr"},{"key":"ref114","doi-asserted-by":"publisher","first-page":"918","DOI":"10.3390\/ijms241914918","article-title":"Prebiotics and probiotics: therapeutic tools for nonalcoholic fatty liver disease","volume":"24","author":"Mijangos-Trejo","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref115","doi-asserted-by":"publisher","first-page":"e36565","DOI":"10.7759\/cureus.36565","article-title":"Probiotics in irritable bowel syndrome: A review article","volume":"15","author":"Sharma","year":"2023","journal-title":"Cureus"},{"key":"ref116","doi-asserted-by":"publisher","first-page":"194","DOI":"10.3390\/microorganisms12010194","article-title":"The networked interaction between probiotics and intestine in health and disease: A promising success story","volume":"12","author":"Skoufou","year":"2024","journal-title":"Microorganisms"},{"key":"ref117","doi-asserted-by":"publisher","first-page":"409","DOI":"10.3390\/ijms23105409","article-title":"Probiotics function in preventing atopic dermatitis in children","volume":"23","author":"Anania","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref118","doi-asserted-by":"publisher","first-page":"e12283","DOI":"10.1002\/clt2.12283","article-title":"Efficacy of probiotics in pediatric atopic dermatitis: A systematic review and meta-analysis","volume":"13","author":"Xue","year":"2023","journal-title":"Clin Transl Allergy"},{"key":"ref119","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1152\/physiol.00005.2020","article-title":"Gut microbiota in liver disease: what do we know and what do we not know?","volume":"35","author":"Jiang","year":"2020","journal-title":"Physiology (Bethesda)"},{"key":"ref120","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/nrgastro.2017.75","article-title":"Expert consensus document: the international scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics","volume":"14","author":"Gibson","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref121","doi-asserted-by":"publisher","first-page":"92","DOI":"10.3390\/foods8030092","article-title":"Prebiotics: definition, types, sources, mechanisms, and clinical applications","volume":"8","author":"Davani-Davari","year":"2019","journal-title":"Foods"},{"key":"ref122","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/S0899-9007(00)00244-6","article-title":"Fructooligosaccharides and gastrointestinal tract","volume":"16","author":"Roberfroid","year":"2000","journal-title":"Nutrition"},{"key":"ref123","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3390\/ijms23116097","article-title":"Prebiotics as a tool for the prevention and treatment of obesity and diabetes: classification and ability to modulate the gut microbiota","volume":"23","author":"Megur","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref124","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1038\/nrgastro.2015.47","article-title":"Towards a more comprehensive concept for prebiotics","volume":"12","author":"Bindels","year":"2015","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref125","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1017\/S0007114510003363","article-title":"Prebiotic effects: metabolic and health benefits","volume":"104","author":"Roberfroid","year":"2010","journal-title":"Br J Nutr"},{"key":"ref126","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/1741-7015-9-24","article-title":"'Gut health': a new objective in medicine?","volume":"9","author":"Bischoff","year":"2011","journal-title":"BMC Med"},{"key":"ref127","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/1462-2920.13589","article-title":"Formation of propionate and butyrate by the human colonic microbiota","volume":"19","author":"Louis","year":"2017","journal-title":"Environ Microbiol"},{"key":"ref128","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","article-title":"From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites","volume":"165","author":"Koh","year":"2016","journal-title":"Cell"},{"key":"ref129","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/s41575-018-0061-2","article-title":"You are what you eat: diet, health and the gut microbiota","volume":"16","author":"Zmora","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref130","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.3945\/jn.109.104638","article-title":"Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers","volume":"139","author":"Peng","year":"2009","journal-title":"J Nutr"},{"key":"ref131","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1016\/j.jcmgh.2021.02.007","article-title":"Regulation of intestinal barrier function by microbial metabolites","volume":"11","author":"Ghosh","year":"2021","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"ref132","doi-asserted-by":"publisher","first-page":"ji1700105","DOI":"10.4049\/jimmunol.1700105","article-title":"Microbial-derived butyrate promotes epithelial barrier function through IL-10 receptor\u2013dependent repression of claudin-2","volume":"199","author":"Zheng","year":"2017","journal-title":"J Immunol"},{"key":"ref133","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1002\/cphy.c170050","article-title":"Role of short chain fatty acid receptors in intestinal physiology and pathophysiology","volume":"8","author":"Priyadarshini","year":"2018","journal-title":"Compr Physiol"},{"key":"ref134","doi-asserted-by":"publisher","first-page":"662739","DOI":"10.3389\/fphys.2021.662739","article-title":"Participation of short-chain fatty acids and their receptors in gut inflammation and Colon Cancer","volume":"12","author":"Carretta","year":"2021","journal-title":"Front Physiol"},{"key":"ref135","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.molimm.2022.05.121","article-title":"Nrf2 activation and NF-kb & caspase\/bax signaling inhibition by sodium butyrate alleviates LPS-induced cell injury in bovine mammary epithelial cells","volume":"148","author":"Ali","year":"2022","journal-title":"Mol Immunol"},{"key":"ref136","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s13105-017-0568-y","article-title":"Sodium butyrate protects against oxidative stress in HepG2 cells through modulating Nrf2 pathway and mitochondrial function","volume":"73","author":"Xing","year":"2016","journal-title":"J Physiol Biochem"},{"key":"ref137","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1093\/carcin\/bgaa039","article-title":"NRF2 as a regulator of cell metabolism and inflammation in cancer","volume":"41","author":"He","year":"2020","journal-title":"Carcinogenesis"},{"key":"ref138","doi-asserted-by":"publisher","first-page":"2172671","DOI":"10.1080\/19490976.2023.2172671","article-title":"Bile acids as modulators of gut microbiota composition and function","volume":"15","author":"Larabi","year":"2023","journal-title":"Gut Microbes"},{"key":"ref139","doi-asserted-by":"publisher","first-page":"G554","DOI":"10.1152\/ajpgi.00223.2019","article-title":"Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy","volume":"318","author":"Chiang","year":"2020","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref140","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/s41392-024-01811-6","article-title":"Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets","volume":"9","author":"Fleishman","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"ref141","doi-asserted-by":"publisher","first-page":"1355542","DOI":"10.3389\/fnut.2024.1355542","article-title":"Unveiling the therapeutic symphony of probiotics, prebiotics, and postbiotics in gut-immune harmony","volume":"11","author":"Zhou","year":"2024","journal-title":"Front Nutr"},{"key":"ref142","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1007\/s11605-021-05188-7","article-title":"The role of gut-derived lipopolysaccharides and the intestinal barrier in fatty liver diseases","volume":"26","author":"An","year":"2022","journal-title":"J Gastrointest Surg"},{"key":"ref143","doi-asserted-by":"publisher","first-page":"805","DOI":"10.3390\/ijms23158805","article-title":"The effects of probiotics, prebiotics and synbiotics in non-alcoholic fat liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH): a systematic review","volume":"23","author":"Carpi","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref144","doi-asserted-by":"publisher","first-page":"26087","DOI":"10.3390\/ijms161125942","article-title":"The role of oxidative stress and antioxidants in liver diseases","volume":"16","author":"Li","year":"2015","journal-title":"Int J Mol Sci"},{"key":"ref145","doi-asserted-by":"publisher","first-page":"813","DOI":"10.3390\/ijms24043813","article-title":"Bioaccessibility and bioavailability of diet polyphenols and their modulation of gut microbiota","volume":"24","author":"Lippolis","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref146","doi-asserted-by":"publisher","first-page":"739","DOI":"10.3390\/foods13050739","article-title":"Local and systemic effects of bioactive food ingredients: is there a role for functional foods to prime the gut for resilience?","volume":"13","author":"Jacquier","year":"2024","journal-title":"Foods"},{"key":"ref147","volume-title":"Advanced Studies in the 21st Century Animal Nutrition","author":"Magdalena","year":"2021"},{"key":"ref148","doi-asserted-by":"publisher","first-page":"204","DOI":"10.2174\/138161210790112674","article-title":"Pharmacogenetics of phase I and phase II drug metabolism","volume":"16","author":"Crettol","year":"2009","journal-title":"Curr Pharm Des"},{"key":"ref149","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3390\/ijms22179109","article-title":"Cellular defensive mechanisms of tea polyphenols: structure-activity relationship","volume":"22","author":"Truong","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref150","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of nrf2 in oxidative stress and toxicity","volume":"53","author":"Ma","year":"2013","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"ref151","volume-title":"Evolving Concepts in Insulin Resistance","author":"Barry","year":"2022"},{"key":"ref152","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref153","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s00109-016-1474-4","article-title":"Interaction between gut microbiota and toll-like receptor: from immunity to metabolism","volume":"95","author":"Yiu","year":"2017","journal-title":"J Mol Med (Berl)"},{"key":"ref154","doi-asserted-by":"publisher","first-page":"102952","DOI":"10.1016\/j.ctim.2023.102952","article-title":"Effects of curcumin\/turmeric supplementation on liver function in adults: A GRADE-assessed systematic review and dose\u2013response meta-analysis of randomized controlled trials","volume":"74","author":"Dehzad","year":"2023","journal-title":"Complement Ther Med"},{"key":"ref155","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.nutres.2014.09.005","article-title":"Resveratrol supplementation improves inflammatory biomarkers in patients with nonalcoholic fatty liver disease","volume":"34","author":"Faghihzadeh","year":"2014","journal-title":"Nutr Res"},{"key":"ref156","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1186\/s12935-021-02280-5","article-title":"Resveratrol mediates its anti-cancer effects by Nrf2 signaling pathway activation","volume":"21","author":"Alavi","year":"2021","journal-title":"Cancer Cell Int"},{"key":"ref157","doi-asserted-by":"publisher","first-page":"110234","DOI":"10.1016\/j.biopha.2020.110234","article-title":"The therapeutic effect of resveratrol: focusing on the Nrf2 signaling pathway","volume":"127","author":"Farkhondeh","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"ref158","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1039\/C9FO01519A","article-title":"Dietary resveratrol attenuated colitis and modulated gut microbiota in dextran sulfate sodium-treated mice","volume":"11","author":"Li","year":"2020","journal-title":"Food Funct"},{"key":"ref159","doi-asserted-by":"publisher","first-page":"833346","DOI":"10.3389\/fvets.2022.833346","article-title":"Effect of lycopene on the growth performance, antioxidant enzyme activity, and expression of gene in the Keap1-Nrf2 signaling pathway of arbor acres broilers","volume":"9","author":"Wang","year":"2022","journal-title":"Front Vet Sci"},{"key":"ref160","doi-asserted-by":"publisher","first-page":"452","DOI":"10.3390\/antiox13040452","article-title":"Lycopene as a therapeutic agent against aflatoxin B1-related toxicity: mechanistic insights and future directions","volume":"13","author":"Li","year":"2024","journal-title":"Antioxidants"},{"key":"ref161","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.3390\/ani13081274","article-title":"The synergistic effects of the combination of L-carnitine and lycopene on the lycopene bioavailability and duodenal health of roosters","volume":"13","author":"Ennab","year":"2023","journal-title":"Animals"},{"key":"ref162","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1111\/1541-4337.12547","article-title":"Bioavailability of nutraceuticals: role of the food matrix, processing conditions, the gastrointestinal tract, and nanodelivery systems","volume":"19","author":"Dima","year":"2020","journal-title":"Compr Rev Food Sci Food Saf"},{"key":"ref163","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.jff.2013.12.010","article-title":"Common delivery systems for enhancing in vivo bioavailability and biological efficacy of nutraceuticals","volume":"7","author":"Ting","year":"2014","journal-title":"J Funct Foods"},{"key":"ref164","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1021\/mp700113r","article-title":"Bioavailability of curcumin: problems and promises","volume":"4","author":"Anand","year":"2007","journal-title":"Mol Pharm"},{"key":"ref165","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1208\/s12248-012-9432-8","article-title":"Therapeutic roles of curcumin: lessons learned from clinical trials","volume":"15","author":"Gupta","year":"2013","journal-title":"AAPS J"},{"key":"ref166","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1021\/acs.jmedchem.6b00975","article-title":"The essential medicinal chemistry of curcumin: miniperspective","volume":"60","author":"Nelson","year":"2017","journal-title":"J Med Chem"},{"key":"ref167","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1055\/s-2006-957450","article-title":"Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers","volume":"64","author":"Shoba","year":"1998","journal-title":"Planta Med"},{"key":"ref168","doi-asserted-by":"publisher","first-page":"6027","DOI":"10.2147\/IJN.S132434","article-title":"Liposomal curcumin and its application in cancer","volume":"12","author":"Feng","year":"2017","journal-title":"Int J Nanomedicine"},{"key":"ref169","first-page":"8","article-title":"The brain and mycotoxins","volume":"26","author":"Campbell","year":"2020","journal-title":"Altern Ther Health Med"},{"key":"ref170","doi-asserted-by":"publisher","first-page":"1","DOI":"10.21926\/obm.neurobiol.2501277","article-title":"Neurotoxicity following exposure to micro and nanoplastics","volume":"9","author":"Ehsanifar","year":"2025","journal-title":"OBM Neurobiol"},{"key":"ref171","doi-asserted-by":"publisher","first-page":"758","DOI":"10.3390\/toxins13110758","article-title":"Intestinal barrier, claudins and mycotoxins","volume":"13","author":"Kozie\u0142","year":"2021","journal-title":"Toxins"},{"key":"ref172","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s13273-025-00545-y","article-title":"The role of tight junctions in the pathogenesis of inflammatory bowel disease: immune modulation and barrier dysfunction","volume":"21","author":"Heo","year":"2025","journal-title":"Mol Cell Toxicol"},{"key":"ref173","doi-asserted-by":"publisher","first-page":"3204","DOI":"10.3390\/ijms23063204","article-title":"Preventing bacterial translocation in patients with leaky gut syndrome: nutrition and pharmacological treatment options","volume":"23","author":"Twardowska","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref174","doi-asserted-by":"publisher","first-page":"121784","DOI":"10.1016\/j.envpol.2023.121784","article-title":"T-2 toxin metabolism and its hepatotoxicity: new insights on the molecular mechanism and detoxification","volume":"330","author":"Song","year":"2023","journal-title":"Environ Pollut"},{"key":"ref175","doi-asserted-by":"publisher","first-page":"3748","DOI":"10.3390\/ijms24043748","article-title":"Natural products as modulators of Nrf2 signaling pathway in neuroprotection","volume":"24","author":"Moratilla-Rivera","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref176","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1007\/s00204-024-03696-4","article-title":"Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants","volume":"98","author":"Jomova","year":"2024","journal-title":"Arch Toxicol"},{"key":"ref177","first-page":"147","volume-title":"Environmental Contaminants and Endocrine Health. Acta Endocrinol. Bucharest.","author":"Carnevali","year":"2023"},{"key":"ref178","doi-asserted-by":"publisher","first-page":"113982","DOI":"10.1016\/j.fct.2023.113982","article-title":"A review of anorexia induced by T-2 toxin","volume":"179","author":"Huang","year":"2023","journal-title":"Food Chem Toxicol"},{"key":"ref179","doi-asserted-by":"publisher","first-page":"e493","DOI":"10.1093\/nutrit\/nuae032","article-title":"Mycotoxins and bone growth: a review of the literature on associations between xenobiotic exposure and bone growth and development","volume":"83","author":"Mehta","year":"2025","journal-title":"Nutr Rev"},{"key":"ref180","doi-asserted-by":"publisher","first-page":"574","DOI":"10.3390\/toxins17120574","article-title":"Mycotoxin-induced oxidative stress and its impact on human Folliculogenesis: examining the link to reproductive health","volume":"17","author":"Sz\u0151ke","year":"2025","journal-title":"Toxins"},{"key":"ref181","doi-asserted-by":"publisher","first-page":"2578","DOI":"10.1002\/jsfa.70168","article-title":"Probiotics as modulators of intestinal barrier integrity and immune homeostasis: a comprehensive review","volume":"106","author":"Mercado-Monroy","year":"2026","journal-title":"J Sci Food Agric"},{"key":"ref182","doi-asserted-by":"publisher","first-page":"7423","DOI":"10.1039\/D2FO00911K","article-title":"Probiotics and gut microbiota: mechanistic insights into gut immune homeostasis through TLR pathway regulation","volume":"13","author":"Kaur","year":"2022","journal-title":"Food Funct"},{"key":"ref183","doi-asserted-by":"publisher","first-page":"111373","DOI":"10.1016\/j.fct.2020.111373","article-title":"Effects of deoxynivalenol on the porcine growth performance and intestinal microbiota and potential remediation by a modified HSCAS binder","volume":"141","author":"Liu","year":"2020","journal-title":"Food Chem Toxicol"},{"key":"ref184","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.3390\/toxins6072064","article-title":"The effect of experimental fusarium mycotoxicosis on microbiota diversity in porcine ascending colon contents","volume":"6","author":"Piotrowska","year":"2014","journal-title":"Toxins"},{"key":"ref185","doi-asserted-by":"publisher","first-page":"477","DOI":"10.3382\/ps\/pex342","article-title":"Effect of yeast cell wall on the growth performance and gut health of broilers challenged with aflatoxin B1 and necrotic enteritis","volume":"97","author":"Liu","year":"2018","journal-title":"Poult Sci"},{"key":"ref186","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3389\/fvets.2016.00010","article-title":"Leaky gut and mycotoxins: aflatoxin B1 does not increase gut permeability in broiler chickens","volume":"3","author":"Galarza-Seeber","year":"2016","journal-title":"Front Vet Sci"},{"key":"ref187","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13567-015-0234-8","article-title":"Fumonisins affect the intestinal microbial homeostasis in broiler chickens, predisposing to necrotic enteritis","volume":"46","author":"Antonissen","year":"2015","journal-title":"Vet Res"},{"key":"ref188","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40168-019-0761-z","article-title":"Ochratoxin A induces liver inflammation: involvement of intestinal microbiota","volume":"7","author":"Wang","year":"2019","journal-title":"Microbiome"},{"key":"ref189","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/3623274","article-title":"Zearalenone changes the diversity and composition of caecum microbiota in weaned rabbit","volume":"2018","author":"Li","year":"2018","journal-title":"Biomed Res Int"},{"key":"ref190","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.taap.2019.04.009","article-title":"Metagenomic analysis of gut microbiota alteration in a mouse model exposed to mycotoxin deoxynivalenol","volume":"372","author":"Wang","year":"2019","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref191","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.toxicon.2018.09.005","article-title":"Isolation and characterization of the Bacillus cereus BC7 strain, which is capable of zearalenone removal and intestinal flora modulation in mice","volume":"155","author":"Wang","year":"2018","journal-title":"Toxicon"},{"key":"ref192","doi-asserted-by":"publisher","first-page":"e80578","DOI":"10.1371\/journal.pone.0080578","article-title":"Evaluation of an oral subchronic exposure of deoxynivalenol on the composition of human gut microbiota in a model of human microbiota-associated rats","volume":"8","author":"Saint-Cyr","year":"2013","journal-title":"PLoS One"},{"key":"ref193","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.fct.2018.08.006","article-title":"Monitoring and evaluation of the interaction between deoxynivalenol and gut microbiota in Wistar rats by mass spectrometry-based metabolomics and next-generation sequencing","volume":"121","author":"Mir\u00f3-Abella","year":"2018","journal-title":"Food Chem Toxicol"},{"key":"ref194","doi-asserted-by":"publisher","first-page":"578","DOI":"10.3390\/toxins12090578","article-title":"The effect of using new synbiotics on the Turkey performance, the intestinal microbiota and the fecal enzymes activity in turkeys fed ochratoxin a contaminated feed","volume":"12","author":"\u015ali\u017cewska","year":"2020","journal-title":"Toxins"},{"key":"ref195","doi-asserted-by":"publisher","first-page":"10787","DOI":"10.1021\/acs.jafc.3c02617","article-title":"Aflatoxin B1 induces inflammatory liver injury via gut microbiota in mice","volume":"71","author":"Ye","year":"2023","journal-title":"J Agric Food Chem"},{"key":"ref196","doi-asserted-by":"publisher","first-page":"131172","DOI":"10.1016\/j.jhazmat.2023.131172","article-title":"Mycotoxin deoxynivalenol-induced intestinal flora disorders, dysfunction and organ damage in broilers and pigs","volume":"451","author":"Jia","year":"2023","journal-title":"J Hazard Mater"},{"key":"ref197","doi-asserted-by":"publisher","first-page":"124489","DOI":"10.1016\/j.jhazmat.2020.124489","article-title":"Melatonin ameliorates ochratoxin A induced liver inflammation, oxidative stress and mitophagy in mice involving in intestinal microbiota and restoring the intestinal barrier function","volume":"407","author":"Zhang","year":"2021","journal-title":"J Hazard Mater"},{"key":"ref198","doi-asserted-by":"publisher","first-page":"347","DOI":"10.3390\/biology15040347","article-title":"Lycopene attenuates T2 mycotoxin-induced hepatotoxicity and dysbiosis by activating PPAR signaling","volume":"15","author":"Ennab","year":"2026","journal-title":"Biology"},{"key":"ref199","doi-asserted-by":"publisher","first-page":"819","DOI":"10.3390\/antiox12040819","article-title":"Total flavonoids of rhizoma drynariae mitigates aflatoxin B1-induced liver toxicity in chickens via microbiota-gut-liver axis interaction mechanisms","volume":"12","author":"Huang","year":"2023","journal-title":"Antioxidants"},{"key":"ref200","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.neuro.2015.06.008","article-title":"Impact of aflatoxin B1 on hypothalamic neuropeptides regulating feeding behavior","volume":"49","author":"Trebak","year":"2015","journal-title":"Neurotoxicology"},{"key":"ref201","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/j.chemosphere.2018.11.058","article-title":"Exposure to aflatoxin B1 interferes with locomotion and neural development in zebrafish embryos and larvae","volume":"217","author":"Wu","year":"2019","journal-title":"Chemosphere"},{"key":"ref202","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.etap.2018.04.003","article-title":"Aflatoxin B1-contaminated diet disrupts the blood\u2013brain barrier and affects fish behavior: involvement of neurotransmitters in brain synaptosomes","volume":"60","author":"Baldissera","year":"2018","journal-title":"Environ Toxicol Pharmacol"},{"key":"ref203","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1038\/s41385-018-0042-3","article-title":"Evidence for interplay among antibacterial-induced gut microbiota disturbance, neuro-inflammation, and anxiety in mice","volume":"11","author":"Jang","year":"2018","journal-title":"Mucosal Immunol"},{"key":"ref204","doi-asserted-by":"publisher","first-page":"671353","DOI":"10.3389\/fnut.2021.671353","article-title":"Quercetin ameliorates gut microbiota dysbiosis that drives hypothalamic damage and hepatic lipogenesis in monosodium glutamate-induced abdominal obesity","volume":"8","author":"Zhao","year":"2021","journal-title":"Front Nutr"},{"key":"ref205","doi-asserted-by":"publisher","first-page":"108622","DOI":"10.1016\/j.jnutbio.2021.108622","article-title":"Diet-induced obesity leads to alterations in behavior and gut microbiota composition in mice","volume":"92","author":"J\u00fanior","year":"2021","journal-title":"J Nutr Biochem"},{"key":"ref206","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1016\/j.neuroscience.2010.08.005","article-title":"Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression","volume":"170","author":"Desbonnet","year":"2010","journal-title":"Neuroscience"},{"key":"ref207","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/nrn3346","article-title":"Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour","volume":"13","author":"Cryan","year":"2012","journal-title":"Nat Rev Neurosci"},{"key":"ref208","doi-asserted-by":"publisher","first-page":"34","DOI":"10.3389\/fpsyt.2019.00034","article-title":"Systematic review of gut microbiota and major depression","volume":"10","author":"Cheung","year":"2019","journal-title":"Front Psych"},{"key":"ref209","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1053\/j.gastro.2017.05.003","article-title":"Probiotic Bifidobacterium longum NCC3001 reduces depression scores and alters brain activity: a pilot study in patients with irritable bowel syndrome","volume":"153","author":"Pinto-Sanchez","year":"2017","journal-title":"Gastroenterology"},{"key":"ref210","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1097\/PSY.0000000000000519","article-title":"Brain-gut-microbiota axis and mental health","volume":"79","author":"Dinan","year":"2017","journal-title":"Psychosom Med"},{"key":"ref211","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1007\/s00213-014-3810-0","article-title":"Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers","volume":"232","author":"Schmidt","year":"2015","journal-title":"Psychopharmacology"},{"key":"ref212","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.neuropharm.2015.04.017","article-title":"The effect of trans-resveratrol on post-stroke depression via regulation of hypothalamus\u2013pituitary\u2013adrenal axis","volume":"97","author":"Pang","year":"2015","journal-title":"Neuropharmacology"},{"key":"ref213","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.neuropharm.2014.04.021","article-title":"Chronic resveratrol treatment exerts antihyperalgesic effect and corrects co-morbid depressive like behaviors in mice with mononeuropathy: involvement of serotonergic system","volume":"85","author":"Zhao","year":"2014","journal-title":"Neuropharmacology"},{"key":"ref214","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1007\/s11011-018-0353-9","article-title":"Combined actions of blueberry extract and lithium on neurochemical changes observed in an experimental model of mania: exploiting possible synergistic effects","volume":"34","author":"Spohr","year":"2019","journal-title":"Metab Brain Dis"},{"key":"ref215","doi-asserted-by":"publisher","first-page":"e0117451","DOI":"10.1371\/journal.pone.0117451","article-title":"Probiotics (Lactobacillus rhamnosus R0011 and acidophilus R0052) reduce the expression of toll-like receptor 4 in mice with alcoholic liver disease","volume":"10","author":"Hong","year":"2015","journal-title":"PLoS One"},{"key":"ref216","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12944-016-0392-3","article-title":"Flaxseed oil ameliorates alcoholic liver disease via anti-inflammation and modulating gut microbiota in mice","volume":"16","author":"Zhang","year":"2017","journal-title":"Lipids Health Dis"},{"key":"ref217","doi-asserted-by":"publisher","first-page":"1500899","DOI":"10.1002\/mnfr.201500899","article-title":"Rhubarb extract prevents hepatic inflammation induced by acute alcohol intake, an effect related to the modulation of the gut microbiota","volume":"61","author":"Neyrinck","year":"2017","journal-title":"Mol Nutr Food Res"},{"key":"ref218","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1124\/jpet.108.148643","article-title":"Oats supplementation prevents alcohol-induced gut leakiness in rats by preventing alcohol-induced oxidative tissue damage","volume":"329","author":"Tang","year":"2009","journal-title":"J Pharmacol Exp Ther"},{"key":"ref219","doi-asserted-by":"publisher","first-page":"108491","DOI":"10.1016\/j.jnutbio.2020.108491","article-title":"Impacts of fish oil on the gut microbiota of rats with alcoholic liver damage","volume":"86","author":"Chen","year":"2020","journal-title":"J Nutr Biochem"},{"key":"ref220","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1080\/13880209.2018.1479868","article-title":"Effects of garlic polysaccharide on alcoholic liver fibrosis and intestinal microflora in mice","volume":"56","author":"Wang","year":"2018","journal-title":"Pharm Biol"},{"key":"ref221","first-page":"33741","article-title":"Food labeling: revision of the nutrition and supplement facts labels. Final rule","volume":"81","year":"2016","journal-title":"Federal Reg"},{"key":"ref222","doi-asserted-by":"publisher","first-page":"440","DOI":"10.3390\/foods8100440","article-title":"Targeting gut microbiota for the prevention and management of diabetes mellitus by dietary natural products","volume":"8","author":"Li","year":"2019","journal-title":"Foods"},{"key":"ref223","doi-asserted-by":"publisher","first-page":"1120254","DOI":"10.3389\/fnut.2023.1120254","article-title":"Lycopene prevents non-alcoholic fatty liver disease through regulating hepatic NF-\u03baB\/NLRP3 inflammasome pathway and intestinal microbiota in mice fed with high-fat and high-fructose diet","volume":"10","author":"Gao","year":"2023","journal-title":"Front Nutr"},{"key":"ref224","doi-asserted-by":"publisher","first-page":"8061","DOI":"10.3748\/wjg.v21.i26.8061","article-title":"Ameliorative effects of lutein on non-alcoholic fatty liver disease in rats","volume":"21","author":"Qiu","year":"2015","journal-title":"World J Gastroenterol"},{"key":"ref225","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1042\/bj20021619","article-title":"Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element","volume":"371","author":"Balogun","year":"2003","journal-title":"Biochem J"},{"key":"ref226","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.nbt.2011.05.003","article-title":"Hepatoprotection of quercetin against oxidative stress by induction of metallothionein expression through activating MAPK and PI3K pathways and enhancing Nrf2 DNA-binding activity","volume":"28","author":"Weng","year":"2011","journal-title":"New Biotechnol"},{"key":"ref227","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/128_2012_339","volume-title":"Natural Products in cancer Prevention and Therapy","author":"Kensler","year":"2012"}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2026.1852579\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:22:58Z","timestamp":1780492978000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2026.1852579\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,3]]},"references-count":227,"alternative-id":["10.3389\/fvets.2026.1852579"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2026.1852579","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,3]]},"article-number":"1852579"}}