{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:46:46Z","timestamp":1782280006955,"version":"3.54.5"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006109","name":"Vedeck\u00e1 Grantov\u00e1 Agent\u00fara M\u0160VVa\u0160 SR a SAV","doi-asserted-by":"publisher","award":["1\/0402\/25"],"award-info":[{"award-number":["1\/0402\/25"]}],"id":[{"id":"10.13039\/501100006109","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006108","name":"Kult\u00farna a Edukacn\u00e1 Grantov\u00e1 Agent\u00fara M\u0160VVa\u0160 SR","doi-asserted-by":"publisher","award":["007UVLF-4\/2025"],"award-info":[{"award-number":["007UVLF-4\/2025"]}],"id":[{"id":"10.13039\/501100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>\n                    An 8-month-old vaccinated male English Cocker Spaniel was presented with hemorrhagic diarrhea, vomiting, and lethargy. Canine parvovirus (CPV-2) infection was indicated by a weakly positive rapid antigen test and confirmed by a combination of serological, molecular, and virological methods. Serological analysis revealed a high IgM titer (1:2,700) and the absence of IgG antibodies, while hemagglutination inhibition (HI) and serum neutralization tests (SNT) confirmed the presence of functional antibodies (\u22651:640). Molecular characterization based on the\n                    <jats:italic>VP2<\/jats:italic>\n                    gene (1,755 bp) identified the CPV-2c variant with amino acid signatures (5Gly, 267Tyr, 324Ile, 370Arg, and 440Thr) typical of the \u201cAsian\u201d lineage. The virus was successfully isolated in A-72 cell culture with characteristic cytopathic effects (CPE). Following intensive supportive therapy, the dog was discharged in stable condition. This report provides molecular evidence of the circulation of \u201cAsian\u201d CPV-2c variants in Central Europe and highlights the importance of comprehensive diagnostic approaches in vaccinated dogs.\n                  <\/jats:p>","DOI":"10.3389\/fvets.2026.1864309","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:51:19Z","timestamp":1782276679000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute hemorrhagic gastroenteritis caused by an \u201cAsian\u201d CPV-2c variant in a vaccinated dog from Slovakia (Central Europe): a case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Patr\u00edcia","family":"Petrou\u0161kov\u00e1","sequence":"first","affiliation":[{"name":"Department of Epizootiology, Parasitology and Protection of One Health, University of Veterinary Medicine and Pharmacy in Ko\u0161ice","place":["Ko\u0161ice, Slovakia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Pelegrinov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Epizootiology, Parasitology and Protection of One Health, University of Veterinary Medicine and Pharmacy in Ko\u0161ice","place":["Ko\u0161ice, Slovakia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Dr\u00e1\u017eovsk\u00e1","sequence":"additional","affiliation":[{"name":"Department of Epizootiology, Parasitology and Protection of One Health, University of Veterinary Medicine and Pharmacy in Ko\u0161ice","place":["Ko\u0161ice, Slovakia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Ondrejkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Epizootiology, Parasitology and Protection of One Health, University of Veterinary Medicine and Pharmacy in Ko\u0161ice","place":["Ko\u0161ice, 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