{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T05:24:38Z","timestamp":1786944278381,"version":"build-2736575974"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>Juvenile angiomatosis is a rare vascular anomaly that has never been examined by ultrasonography and computed tomography in bovine practice. A four-days-old, Japanese-Black, male calf presented with multiple swollen skin lesions aligned along the dorsoventral axis of the left thoracic wall. Ultrasonography showed homogeneous echogenic masses between the subcutaneous and muscular structures. Anatomical connection between the mass lesions and neighboring structures was ultrasonographically unclear based on differences in echogenicity and the hyperechoic membranous structures between them. Doppler ultrasonography revealed poor vascularity, which is a common feature of mass lesions. Computed tomography (CT) revealed seven masses in the left thoracic wall. Five of the seven masses were isolated from each other, although there was an anatomical connection between two masses formed at the level of the spinous processes of the ninth to thirteenth thoracic vertebrae. The largest mass was located in the most ventral region of the thoracic wall, corresponding to deformities of the sixth to tenth ribs, which showed severe inward rolling into the thoracic cavity on three-dimensional CT. Core-needle biopsy allowed histopathological observation of the predominant intra-mass configuration of vessel-like structures. Histopathological examination of tissue samples collected at necropsy revealed that multiple immature vessel-like structures were present within the mass lesions that commonly involved the skeletal muscles. Positive immunostaining was found for von Willebrand factor in the endothelial cells, and for alpha-smooth muscle actin in the cells comprising the walls. These findings could support a diagnosis of bovine juvenile angiomatosis. Both ultrasonography and CT provided no definitive evidence to support the macroscopic and histopathological findings showing invasion of the masses into neighboring muscular structures. A combination of diagnostic techniques, including ultrasonography, CT, and core-needle biopsy, helped provide complementary information that supported the histopathological and immunohistochemical diagnosis of this disease.<\/jats:p>","DOI":"10.3389\/fvets.2026.1882023","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T04:34:55Z","timestamp":1786941295000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Diagnosis of multiple juvenile angiomatosis in a newborn calf"],"prefix":"10.3389","volume":"13","author":[{"given":"Takeshi","family":"Tsuka","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Medicine, Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University","place":["Tottori, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kodai","family":"Kusuda","sequence":"additional","affiliation":[{"name":"Kusunoki Large Animal Clinic","place":["Tottori, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohta","family":"Hishikawa","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine, Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University","place":["Tottori, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsuki","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine, Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University","place":["Tottori, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Sunden","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine, Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University","place":["Tottori, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"ref1","first-page":"279","article-title":"Juvenile bovine angiomatosis: a syndrome of young cattle","volume":"127","author":"Watson","year":"1990","journal-title":"Vet Rec"},{"key":"ref2","volume-title":"Imaging of Soft Tissue Tumors","author":"Ramon","year":"2006"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"381","DOI":"10.2460\/javma.234.3.381","article-title":"Invasive cutaneous angiomatosis and thrombocytopenia in a cat","volume":"234","author":"Bulman-Fleming","year":"2009","journal-title":"J Am Vet Med Assoc"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e113","DOI":"10.1097\/JOVA.0000000000000113","article-title":"Updated classification of vascular anomalies: a living document from the International Society for the Study of vascular anomalies classification group","volume":"6","author":"Goldenberg","year":"2025","journal-title":"J Vasc Anom"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"36","DOI":"10.17221\/111\/2019-VETMED","article-title":"Cutaneous vascular hamartoma in a lamb","volume":"65","author":"Morais","year":"2020","journal-title":"Vet Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"172","DOI":"10.2460\/javma.1982.181.02.172","article-title":"Disseminated cavernous hemangioma in a calf","volume":"181","author":"Baker","year":"1982","journal-title":"J Am Vet Med Assoc"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.2460\/javma.2001.219.1094","article-title":"Use of laser photocoagulation for treatment of cutaneous angiomatosis in one dog and two cats","volume":"219","author":"Peavy","year":"2001","journal-title":"J Am Vet Med Assoc"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.jcpa.2009.07.006","article-title":"Cutaneous angiomatosis in a llama (Lama glama)","volume":"142","author":"Luppi","year":"2009","journal-title":"J Comp Pathol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"20130392","DOI":"10.1259\/bjr.20130392","article-title":"Vascular anomalies: classification, imaging characteristics and implications for interventional radiology treatment approaches","volume":"87","author":"Mulligan","year":"2014","journal-title":"Br J Radiol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1177\/030098588302000213","article-title":"Congenital multifocal hemangiosarcoma in a stillborn calf","volume":"20","author":"Badylak","year":"1983","journal-title":"Vet Pathol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1177\/0300985809358429","article-title":"Spontaneous regression of congenital cutaneous hemangiomas in a calf","volume":"47","author":"Priestnall","year":"2010","journal-title":"Vet Pathol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/J.JEVS.2012.02.017","article-title":"Clinicopathological features of hemangioma in two young horses","volume":"32","author":"Zafra","year":"2012","journal-title":"J Equine Vet Sci"},{"key":"ref13","first-page":"113","article-title":"Juvenile bovine angiomatosis in the mandible","volume":"36","author":"Richard","year":"1995","journal-title":"Can Vet J"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"341","DOI":"10.3348\/kjr.2019.0343","article-title":"Ultrasonography of pediatric superficial soft tissue tumors and tumor-like lesions","volume":"21","author":"Kim","year":"2020","journal-title":"Korean J Radiol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"624","DOI":"10.3390\/ani11030624","article-title":"Clinicopathological and genomic characterization of a Simmental calf with generalized bovine juvenile angiomatosis","volume":"11","author":"Jacinto","year":"2021","journal-title":"Animals"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1177\/030098587301000306","article-title":"Hemangiomas of a bovine fetus with a chorioangioma of the placenta","volume":"10","author":"Kirkbride","year":"1973","journal-title":"Vet Pathol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1080\/00480169.2013.871194","article-title":"Spontaneous progression of cutaneous angiomatosis to an infiltrative sarcoma-like tumour in a bull","volume":"62","author":"Ruetten","year":"2014","journal-title":"N Z Vet J"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"2652","DOI":"10.1590\/S0103-84782009000900045","article-title":"Pulmonary choristoma associated with calf meningocele","volume":"39","author":"Medeiros de Oliveira","year":"2009","journal-title":"Cienc Rural"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1257329","DOI":"10.3389\/fvets.2023.1257329","article-title":"Case report: diagnosis and treatment of pulmonary choristoma in a newborn calf","volume":"10","author":"Usaki","year":"2024","journal-title":"Front Vet Sci"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1155\/2014\/285834","article-title":"Intramuscular haemangioma with diagnostic challenge: a cause for strange pain in the masseter muscle","volume":"6","author":"Lakshmi","year":"2014","journal-title":"Case Rep Dent"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"952","DOI":"10.2214\/AJR.15.15794","article-title":"Low-flow vascular malformation pitfalls: from clinical examination to practical imaging evaluation\u2014part 2, venous malformation mimickers","volume":"206","author":"Olivieri","year":"2016","journal-title":"Am J Roentgenol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/0895-6111(92)90124-r","article-title":"Diffuse neonatal hemangiomatosis: imaging findings in two patients","volume":"16","author":"Goodman","year":"1992","journal-title":"Comput Med Imaging Graph"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"718135","DOI":"10.3389\/fped.2021.718135","article-title":"Color Doppler evaluation of arterial resistive index in infantile hemangioma: a useful parameter to monitor the response to oral propranolol?","volume":"9","author":"Parapatt","year":"2021","journal-title":"Front Pediatr"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1111\/j.1600-0560.2006.00450.x","article-title":"Diffuse dermal angiomatosis","volume":"33","author":"Draper","year":"2006","journal-title":"J Cutan Pathol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1002\/jcu.22199","article-title":"Diffuse angiomatosis of the breast\u2014sonographic appearance","volume":"42","author":"Ciurea","year":"2014","journal-title":"J Clin Ultrasound"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"e20220502","DOI":"10.1590\/0103-8478cr20220502","article-title":"Clinico-pathological and immunohistochemical findings in a case of bovine cutaneous angiomatosis in a Holstein heifer","volume":"53","author":"de Albuquerque Cerqueira","year":"2023","journal-title":"Cienc Rural"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"2055116917744127","DOI":"10.1177\/2055116917744127","article-title":"Feline vertebral angiomatosis: two cases","volume":"3","author":"Frizzi","year":"2017","journal-title":"JFMS Open Rep"},{"key":"ref28","first-page":"1067","article-title":"Radiation therapy for the treatment of canine progressive cutaneous angiomatosis: description of 2 cases","volume":"59","author":"Laganga","year":"2018","journal-title":"Can Vet J"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"573540","DOI":"10.3389\/fvets.2020.573540","article-title":"A rare case of vascular proliferation in the mandible of a juvenile horse","volume":"7","author":"Leitzen","year":"2020","journal-title":"Front Vet Sci"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"e000908","DOI":"10.1136\/vetreccr-2019-000908","article-title":"Recurrent subcutaneous and muscular angiomatosis with spontaneous regression in a foal","volume":"7","author":"Cerri","year":"2019","journal-title":"Vet Rec Case Rep"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"e143","DOI":"10.1002\/vrc2.143","article-title":"Canine disseminated peritoneal angiomatosis with arterial differentiation in a 10-month-old Rhodesian ridgeback","volume":"9","author":"Bacon","year":"2021","journal-title":"Vet Rec Case Rep"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1177\/0300985810369904","article-title":"Skeletal\u2013extraskeletal angiomatosis in a dog","volume":"47","author":"Kuroki","year":"2010","journal-title":"Vet Pathol"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.jcpa.2026.04.001","article-title":"Skeletal-extraskeletal angiomatosis in a female boxer puppy","volume":"227","author":"Greenberg","year":"2026","journal-title":"J Comp Pathol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"e000925","DOI":"10.1136\/vetreccr-2019-000925","article-title":"Muscular angiomatosis in a dog","volume":"7","author":"Marchis","year":"2019","journal-title":"Vet Rec Case Rep"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1007\/s12105-009-0105-6","article-title":"Angiomatosis in the head and neck\u20143 case reports","volume":"3","author":"Shetty","year":"2009","journal-title":"Head Neck Pathol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1148\/radiology.193.2.7972776","article-title":"Angiomatosis of the abdominal wall: imaging findings in three adults","volume":"193","author":"Radin","year":"1994","journal-title":"Radiology"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.ijscr.2018.08.023","article-title":"Chest wall resection for a giant angiomatosis lesion: a case report","volume":"51","author":"Garza-Serna","year":"2018","journal-title":"Int J Surg Case Rep"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1136\/vr.135.14.333","article-title":"Bovine disseminated haemangioma","volume":"135","author":"Munro","year":"1994","journal-title":"Vet Rec"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s40477-018-0342-1","article-title":"Classification and ultrasound findings of vascular anomalies in pediatric age: the essential","volume":"22","author":"Esposito","year":"2019","journal-title":"J Ultrasound"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1177\/0268355516671463","article-title":"Angiomatosis of soft tissue as an important differential diagnosis for intramuscular venous malformations","volume":"32","author":"Aronniemi","year":"2017","journal-title":"Phlebology"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1186\/s12917-019-2195-z","article-title":"Diagnostic efficacy of imaging and biopsy methods for peritoneal mesothelioma in a calf","volume":"15","author":"Morita","year":"2019","journal-title":"BMC Vet Res"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1369\/jhc.4A6514.2005","article-title":"Immunohistochemical expression of endothelial markers CD31, CD34, von Willebrand factor, and Fli-1 in normal human tissues","volume":"54","author":"Pusztaszeri","year":"2006","journal-title":"J Histochem Cytochem"}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2026.1882023\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T04:35:23Z","timestamp":1786941323000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2026.1882023\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,17]]},"references-count":42,"alternative-id":["10.3389\/fvets.2026.1882023"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2026.1882023","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,17]]},"article-number":"1882023"}}