{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T18:03:30Z","timestamp":1784311410717,"version":"3.55.0"},"reference-count":88,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>\n                    Respiratory diseases represent a major health burden in global livestock production and are driven by bacterial and viral pathogens that trigger severe inflammatory responses and substantial economic losses. Caspase-11 serves as a core component of the non-canonical inflammasome, functioning as an intracellular lipopolysaccharide (LPS) sensor that mediates pyroptosis and inflammatory cytokine maturation. Although extensively studied in human and murine systems, the role of Caspase-11 in veterinary respiratory infections remains poorly characterized. This review synthesizes current knowledge on the structural and regulatory features of the Caspase-11 non-canonical inflammasome, with an emphasis on its involvement in infections caused by major veterinary pathogens, such as\n                    <jats:italic>Pasteurella multocida<\/jats:italic>\n                    and\n                    <jats:italic>Streptococcus suis<\/jats:italic>\n                    . We further evaluated emerging Caspase-11-targeted therapeutic strategies, including anti-inflammatory agents, vaccine adjuvants, and gene-editing approaches, while critically assessing their translational potential in livestock species. By delineating key knowledge gaps, this review highlights the imperative for species-specific functional studies to inform the development of effective interventions against veterinary respiratory diseases.\n                  <\/jats:p>","DOI":"10.3389\/fvets.2026.1891521","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:24:33Z","timestamp":1784309073000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Advances of Caspase-11 for veterinary respiratory infections"],"prefix":"10.3389","volume":"13","author":[{"given":"Yang","family":"Su","sequence":"first","affiliation":[{"name":"College of Animal & Veterinary Sciences, Southwest Minzu University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kehamo","family":"Abi","sequence":"additional","affiliation":[{"name":"College of Animal & Veterinary Sciences, Southwest Minzu University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qibing","family":"Gu","sequence":"additional","affiliation":[{"name":"College of Animal & Veterinary Sciences, Southwest Minzu University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falong","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Animal & Veterinary Sciences, Southwest Minzu University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangfu","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Animal & Veterinary Sciences, Southwest Minzu University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.3390\/ani13071273","article-title":"Can we reliably detect respiratory diseases through precision farming? 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