{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:03:56Z","timestamp":1789571036759,"version":"build-2803163510"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"\n Background<\/jats:title>\n \n Hepatozoon<\/jats:italic>\n , an apicomplexan, mainly infects amphibians, reptiles and mammals, accidentally causes anemia and icterus in human. Large-scale investigation remains lack. This study examined the occurrence of\n Hepatozoon<\/jats:italic>\n spp. in a broad range of hosts in Xinjiang Uygur Autonomous Region (XUAR), northwestern China.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n During 2018\u20132025, 3,344 liver or blood specimens were collected from 3,037 mammals and 307 reptiles across XUAR (covering 1.66\u202fmillion\u202fkm\n 2<\/jats:sup>\n ). Animal species were identified using morphology and mitochondrial gene amplification.\n Hepatozoon<\/jats:italic>\n was identified by PCR targeting\n 18S rRNA<\/jats:italic>\n gene.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 35 animal species were examined (25 mammals and 10 reptiles). The\n Hepatozoon<\/jats:italic>\n infection rate was 2.5% (84\/3344 specimens). All positives were exclusively in Rodentia (6.5%, 84\/1301); no\n Hepatozoon<\/jats:italic>\n DNA was found in the other six mammalian orders (Lagomorpha, Chiroptera, Artiodactyla, Perissodactyla, Carnivora, Primates) or Squamata reptiles. Combined with our previous report on\n Hepatozoon canis<\/jats:italic>\n in the red fox (\n Vulpes vulpes<\/jats:italic>\n ) and\n Hepatozoon felis<\/jats:italic>\n in the Eurasian lynx (\n Lynx lynx<\/jats:italic>\n ), the study detected five additional\n Hepatozoon<\/jats:italic>\n species:\n Hepatozoon chinensis<\/jats:italic>\n ,\n Hepatozoon ayorgbor<\/jats:italic>\n ,\n Hepatozoon ophisauri<\/jats:italic>\n ,\n Hepatozoon<\/jats:italic>\n cf.\n ophisauri<\/jats:italic>\n and one unnamed\n Hepatozoon<\/jats:italic>\n sp.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This study provides the first reports of\n Hepatozoon<\/jats:italic>\n infection in several rodent species:\n Hepatozoon chinensis<\/jats:italic>\n in the root vole (\n Microtus oeconomus<\/jats:italic>\n ),\n H<\/jats:italic>\n .\n ayorgbor<\/jats:italic>\n in the five-toed jerboa (\n Allactaga sibirica<\/jats:italic>\n ),\n H<\/jats:italic>\n .\n ophisauri<\/jats:italic>\n in the mole vole (\n Ellobius talpinus<\/jats:italic>\n ) and five-toed jerboa,\n H<\/jats:italic>\n . cf.\n ophisauri<\/jats:italic>\n in the great gerbil (\n Rhombomys opimus<\/jats:italic>\n ) and Libyan jird (\n Meriones libycus<\/jats:italic>\n ), and\n Hepatozoon<\/jats:italic>\n sp. in the long-tailed ground squirrel (\n Spermophilus undulatus<\/jats:italic>\n ).\n Hepatozoon<\/jats:italic>\n surveillance on more wildlife should be strengthened.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fvets.2026.1897152","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T04:29:40Z","timestamp":1788150580000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular detection and phylogeny of Hepatozoon species in a wide spectrum of hosts from northwestern China"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiaoshuang","family":"Han","sequence":"first","affiliation":[{"name":"Infectious Disease and Liver Disease Center, The First Affiliated Hospital of Xinjiang Medical University","place":["Urumqi, Xinjiang, China"]},{"name":"Key Laboratory of High Incidence Disease Research in Xinjiang (Xinjiang Medical University), Ministry of Education","place":["Urumqi, Xinjiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujie","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security of the XPCC, School of Medicine, Shihezi University","place":["Shihezi, Xinjiang, China"]},{"name":"NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, Shihezi University","place":["Shihezi, Xinjiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security of the XPCC, School of Medicine, Shihezi University","place":["Shihezi, Xinjiang, China"]},{"name":"NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, Shihezi University","place":["Shihezi, Xinjiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Yin","sequence":"additional","affiliation":[{"name":"Xinjiang International Travel Healthcare Center (Urumqi Customs Port Outpatient Department)","place":["Urmqi, Xinjiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weimin","family":"Xiahou","sequence":"additional","affiliation":[{"name":"Shaoguan Customs Comprehensive Technology Service Center","place":["Shaoguan, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Center for Infectious Diseases and Pathogen Biology, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, The First Hospital of Jilin University","place":["Changchun, Jilin, China"]},{"name":"Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Institute of Zoology, Guangdong Academy of Sciences","place":["Guangzhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Tian","sequence":"additional","affiliation":[{"name":"Xinjiang International Travel Healthcare Center (Urumqi Customs Port Outpatient Department)","place":["Urmqi, Xinjiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanzhi","family":"Wang","sequence":"additional","affiliation":[{"name":"Infectious Disease and Liver Disease Center, The First Affiliated Hospital of Xinjiang Medical University","place":["Urumqi, Xinjiang, China"]},{"name":"Key Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security of the XPCC, School of Medicine, Shihezi University","place":["Shihezi, Xinjiang, China"]},{"name":"NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, Shihezi University","place":["Shihezi, Xinjiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Lu","sequence":"additional","affiliation":[{"name":"Infectious Disease and Liver Disease Center, The First Affiliated Hospital of Xinjiang Medical University","place":["Urumqi, Xinjiang, China"]},{"name":"Key Laboratory of High Incidence Disease Research in Xinjiang (Xinjiang Medical University), Ministry of Education","place":["Urumqi, Xinjiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"9014","DOI":"10.1038\/s41598-025-91185-8","article-title":"Leading report on the molecular prevalence of emerging pathogens Hepatozoon sp. and Lankesterella sp. in the blood samples of seven wild lizard species","volume":"15","author":"Shabbir","year":"2025","journal-title":"Sci Rep"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s13071-024-06154-3","article-title":"Hepatozoon (Eucoccidiorida: Hepatozoidae) in wild mammals of the Americas: a systematic review","volume":"17","author":"Thomas","year":"2024","journal-title":"Parasit Vectors"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.vetpar.2011.04.015","article-title":"Perspectives on canine and feline 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Erhardovae in small rodents from Central Europe","volume":"123","author":"Ganzinelli","year":"2024","journal-title":"Parasitol Res"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/1749-4877.12718","article-title":"Long-term monitoring of cycles in Clethrionomys rutilus in the Yukon boreal forest","volume":"19","author":"Krebs","year":"2024","journal-title":"Integr Zool"}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2026.1897152\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:23:08Z","timestamp":1789568588000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2026.1897152\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":43,"alternative-id":["10.3389\/fvets.2026.1897152"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2026.1897152","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,31]]},"article-number":"1897152"}}