{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:03:54Z","timestamp":1791237834245,"version":"4.1.0"},"reference-count":63,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>\n                    Gas bubble disease (GBD) is a non-infectious disease caused by the supersaturation of total dissolved gas (TDG) in aquatic environments, which can damage multiple tissues and organs in aquatic animals and be potentially fatal in severe cases. This study reports, for the first time, clinical symptoms resembling GBD in wild larvae of the endangered Anji salamander (\n                    <jats:italic>Hynobius amjiensis<\/jats:italic>\n                    ). By combining clinical observations, habitat water quality testing, and 16S rRNA sequencing, we investigated the ecological drivers of this disease and its impact on the host\u2019s fecal microbial community. Affected individuals exhibited severe subcutaneous and abdominal emphysema, buoyancy abnormalities, and anorexia; these symptoms resolved spontaneously within 24\u201372\u202fh after transfer to stable water bodies. Puddles where cases occurred exhibited severe eutrophication and massive algal blooms, leading to extreme TDG supersaturation, primarily driven by dissolved oxygen. Furthermore, the species evenness of the fecal microbiota in the affected group showed a decreasing trend, with a massive loss of core commensal bacteria, while the relative abundance of the opportunistic pathogen\n                    <jats:italic>Aeromonas<\/jats:italic>\n                    increased abnormally. These findings indicate that eutrophication-driven physicochemical abnormalities in water bodies may be the primary environmental stressors inducing GBD, while the disease itself may disrupt the organism\u2019s homeostasis, further triggering secondary dysbiosis of the gut microbiota. This study provides a reference for understanding the ecologically driven mechanisms of non-infectious diseases in wild amphibians, as well as for the management and conservation of aquatic environments in the habitats of endangered amphibian species.\n                  <\/jats:p>","DOI":"10.3389\/fvets.2026.1900113","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:46:35Z","timestamp":1787935595000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical observations, environmental parameters, and gut microbiota alterations associated with gas bubble disease in the endangered Anji salamander (Hynobius amjiensis)"],"prefix":"10.3389","volume":"13","author":[{"given":"Haiyan","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Basic Medical Science, Huzhou Normal University","place":["Huzhou, Zhejiang, China"]},{"name":"Anji Salamander (Hynobius amjiensis) National Nature Reserve Management Center","place":["Huzhou, Zhejiang, China"]},{"name":"National-Local Joint Engineering Laboratory of Aquatic Animal Genetic Breeding and Nutrition, Zhejiang Provincial Key Laboratory of Aquatic Resources Conservation and Development, Key Laboratory of Aquatic Animal Genetic Breeding and Nutrition of Chinese Academy of Fishery Sciences, Huzhou Normal University","place":["Huzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minglan","family":"Dong","sequence":"additional","affiliation":[{"name":"National-Local Joint Engineering Laboratory of Aquatic Animal Genetic Breeding and Nutrition, Zhejiang Provincial Key Laboratory of Aquatic Resources Conservation and Development, Key Laboratory of Aquatic Animal Genetic Breeding and Nutrition of Chinese Academy of Fishery Sciences, Huzhou Normal University","place":["Huzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolu","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science, Huzhou Normal University","place":["Huzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhedong","family":"Lang","sequence":"additional","affiliation":[{"name":"Anji Salamander (Hynobius amjiensis) National Nature Reserve Management Center","place":["Huzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianting","family":"Wang","sequence":"additional","affiliation":[{"name":"Anji Salamander (Hynobius amjiensis) National Nature Reserve Management Center","place":["Huzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiabao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science, Huzhou Normal University","place":["Huzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixing","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science, Huzhou Normal University","place":["Huzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science, Huzhou Normal University","place":["Huzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"ref1","first-page":"284","article-title":"Gas bubble disease of fish","volume":"25","author":"Bohl","year":"1997","journal-title":"Tierarztl Prax"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1577\/1548-8659(1980)109<703:EOGBD>2.0.CO;2","article-title":"Etiology of gas bubble disease","volume":"109","author":"Bouck","year":"1980","journal-title":"Trans Am 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