{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:16:51Z","timestamp":1788239811220,"version":"build-2803163510"},"reference-count":84,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Ovine mange is a highly contagious skin disease that causes substantial economic losses. This study assessed the prevalence, SNPs, gene expression, serum APPs, and immune and antioxidant markers to elucidate the immunological and oxidative mechanisms of mange in Barki sheep.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 320 adult Barki ewes were enrolled in the study, comprising 80 clinically affected animals and 240 apparently healthy controls. Blood samples were collected from all animals for the determination of acute-phase proteins, immunological and antioxidant biomarkers, and gene expression analyses of CARD9, CLEC7A, TNFAIP3, IL33, SESN2, ATF4, HSPA1A, and SLC7A11. Only clinically affected sheep underwent parasitological confirmation by microscopic examination of deep skin scrapings collected from active skin lesions to identify mange mites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Microscopic examination confirmed mange in 25% (80\/320) of the ewes, with\n                      <jats:italic>Sarcoptes<\/jats:italic>\n                      spp. accounting for 75% and\n                      <jats:italic>Psoroptes<\/jats:italic>\n                      spp. for 25% of the cases. Infected sheep showed upregulation of CARD9, CLEC7A, IL33, SESN2, ATF4, and HSPA1A, and downregulation of TNFAIP3 and SLC7A11 (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.05), with 14 SNPs differing significantly between the healthy and infected groups. Infected animals showed elevated APPs, pro-inflammatory cytokines, and oxidative stress, with reduced IL-10 levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Ovine mange is associated with distinct molecular, immunological, and oxidative stress responses that reflect the host\u2019s reaction to mite infestation. To our knowledge, this is the first study to integrate transcriptional profiling with SNP characterization of\n                      <jats:italic>CARD9, CLEC7A, TNFAIP3, IL33, SESN2, ATF4, HSPA1A<\/jats:italic>\n                      , and\n                      <jats:italic>SLC7A11<\/jats:italic>\n                      in naturally occurring ovine mange. The identified sequence variants, together with gene expression signatures, provide novel candidate molecular biomarkers for disease susceptibility and may support future genetic selection and precision disease management strategies. Additional studies involving larger and independent sheep populations are needed to validate these findings and determine their potential value in disease susceptibility assessment and genetic improvement programs.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fvets.2026.1902195","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:26:27Z","timestamp":1788236787000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Nucleotide sequence variations, gene expression profiles, and host biomarkers associated with ovine mange caused by Sarcoptes and Psoroptes mites: implications for diagnosis and disease control"],"prefix":"10.3389","volume":"13","author":[{"given":"Manal A.","family":"Babaker","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Majmaah University","place":["Al Majmaah, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Marzok","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, King Faisal University","place":["Al-Ahsa, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"El Sayed","sequence":"additional","affiliation":[{"name":"Department of Animal Health and Poultry, Animal and Poultry Production Division, Desert Research Center (DRC)","place":["Mataryia, Cairo, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahani M. I.","family":"Al-Hazani","sequence":"additional","affiliation":[{"name":"Biology Department, College of Science and Humanities, Prince Sattam bin Abdulaziz University","place":["Al-Kharj, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Ateya","sequence":"additional","affiliation":[{"name":"Department of Development of Animal Wealth, Faculty of Veterinary Medicine, Mansoura University","place":["Mansoura, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatimah S.","family":"Alharbi","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Sciences, Taif University","place":["Taif, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham Mohammed","family":"Alzahrani","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, Princess Nourah bint Abdulrahman University","place":["Riyadh, Saudi 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University","place":["Al-Ahsa, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Al-Rasheed","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, King Faisal University","place":["Al-Ahsa, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha Yassin","family":"Elkhidr","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, King Faisal University","place":["Al-Ahsa, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zakriya","family":"Al Mohamad","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, King Faisal University","place":["Al-Ahsa, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar A.","family":"Al-Jabr","sequence":"additional","affiliation":[{"name":"Department of 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