{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:54:24Z","timestamp":1790862864920,"version":"4.1.0"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Feline hyperthyroidism is one of the most common endocrinopathies in cats; however, its epidemiological characteristics remain poorly understood in South Korea. Although radioactive iodine therapy (RAIT) is a definitive treatment, studies focusing specifically on cats with hyperthyroidism undergoing RAIT are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medical records of 152 cats with hyperthyroidism presented for RAIT were retrospectively reviewed to describe their epidemiological and clinical features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median age at diagnosis was 12 years, and 30.3% of the cats were diagnosed incidentally. RAIT was usually performed soon after diagnosis, with a median disease duration of 5 months; only 4.6% of cats had a disease duration &amp;gt;2 years. Unilateral thyroid disease was the predominant pattern (50.7%), and severe hyperthyroidism (total thyroxine \u226519.4 \u03bcg\/dl) was observed in 10.5% of cats. Only 40.1% of cats underwent RAIT following the veterinarian's recommendation, whereas 59.9% of owners sought RAIT independently. Human-licensed or generic methimazole was used more frequently than veterinary-licensed methimazole (84.0 vs. 18.1%). Pruritus occurred more frequently with human-licensed or generic methimazole than with veterinary-licensed methimazole (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.047). All cats were housed indoors. The regional distribution of cases differed from the reported national distribution of owned cats (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.016). No cats originated from Jeju-do, which differed significantly from the mainland regions (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0004). Longer disease duration was associated with more advanced disease, including higher thyroid hormone levels and scintigraphic activity, increased bilateral involvement, and a higher rate of refractory response to antithyroid drugs (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2264 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This is the first study to characterize cats with hyperthyroidism that were presented for RAIT in South Korea. Key findings included an owner-driven pattern of RAIT selection, early use of definitive therapy despite a relatively late diagnosis, predominant use of non-veterinary methimazole formulations, and a higher frequency of pruritus as an adverse effect. These findings contribute to the epidemiological understanding of feline hyperthyroidism and may inform clinical decision-making in South Korea.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fvets.2026.1906840","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:55:30Z","timestamp":1790859330000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cross-sectional analysis of 152 hyperthyroid cats presented for radioactive iodine therapy in South Korea"],"prefix":"10.3389","volume":"13","author":[{"given":"Dasom","family":"Son","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University","place":["Cheongju, Chungbuk, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon","family":"Chae","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University","place":["Cheongju, Chungbuk, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taesik","family":"Yun","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University","place":["Cheongju, Chungbuk, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakhyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University","place":["Cheongju, Chungbuk, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Cheong","family":"Lim","sequence":"additional","affiliation":[{"name":"Radioisotope Research Division, Korea Atomic Energy Research Institute","place":["Daejeon, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byeong-Teck","family":"Kang","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University","place":["Cheongju, Chungbuk, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/S0195-5616(94)50058-5","article-title":"Etiopathology of feline toxic nodular goiter","volume":"24","author":"Gerber","year":"1994","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"B2","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.cvsm.2007.05.001","article-title":"Etiopathologic findings of hyperthyroidism in cats","volume":"37","author":"Peterson","year":"2007","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"B3","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1177\/1098612X12464462","article-title":"Hyperthyroidism in cats:what's causing this epidemic of thyroid disease and can we prevent it?","volume":"14","author":"Peterson","year":"2012","journal-title":"J Feline Med Surg"},{"key":"B4","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/0167-5877(88)90041-4","article-title":"Feline hyperthyroidism: a descriptive and case-control study","volume":"6","author":"Scarlett","year":"1988","journal-title":"Prev Vet Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1111\/j.1939-1676.1999.tb02189.x","article-title":"Cowgill. 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