{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:13:43Z","timestamp":1786115623538,"version":"build-2736575974"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Ochratoxin A is a toxic mycotoxin produced by fungi, which is commonly detected in contaminated cereals and animal feeds. It exhibits nephrotoxicity, hepatotoxicity, genotoxicity, immunotoxicity, and reproductive toxicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In the present study, we investigated the adverse effects of ochratoxin A on organelle distribution using a porcine oocyte model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We demonstrated that in vitro exposure to ochratoxin A inhibited cumulus cell expansion and polar body extrusion in oocytes. Ochratoxin A reduced cortical endoplasmic reticulum distribution and increased GRP78 expression, indicating the induction of endoplasmic reticulum stress. In contrast, the Golgi apparatus exhibited abnormal accumulation, accompanied by decreased Rab7 expression and aberrant localization, suggesting impaired vesicular transport. Similarly, lysosomes accumulated in the cytoplasm of porcine oocytes following ochratoxin A treatment. We also found that mitochondrial function was disrupted, as evidenced by reduced ATP production and aberrant mitochondrial membrane potential.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Taken together, these results indicate that ochratoxin A impairs organelle distribution, induces endoplasmic reticulum stress, and causes vesicular transport defects during porcine oocyte maturation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fvets.2026.1912554","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T04:24:44Z","timestamp":1785990284000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Exposure to ochratoxin a induces organelle damage during porcine oocyte maturation"],"prefix":"10.3389","volume":"13","author":[{"given":"Lin-Lin","family":"Hu","sequence":"first","affiliation":[{"name":"Guangxi Key Laboratory of Artificial Intelligence for Genetic Diseases of Long-dwelling Nationalities, Affiliated Hospital of Youjiang Medical University for Nationalities","place":["Baise, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yi","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-He","family":"Ke","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Artificial Intelligence for Genetic Diseases of Long-dwelling Nationalities, Affiliated Hospital of Youjiang Medical University for Nationalities","place":["Baise, Guangxi, China"]},{"name":"College of Animal Science and Technology, Nanjing Agricultural University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Min","family":"Ou","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Artificial Intelligence for Genetic Diseases of Long-dwelling Nationalities, Affiliated Hospital of Youjiang Medical University for Nationalities","place":["Baise, Guangxi, China"]},{"name":"College of Animal Science and Technology, Nanjing Agricultural University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan-Lan","family":"Nong","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Artificial Intelligence for Genetic Diseases of Long-dwelling Nationalities, Affiliated Hospital of Youjiang Medical University for Nationalities","place":["Baise, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Zhou","family":"Qin","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Artificial Intelligence for Genetic Diseases of Long-dwelling Nationalities, Affiliated Hospital of Youjiang Medical University for Nationalities","place":["Baise, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Chen","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caizhu","family":"Wang","sequence":"additional","affiliation":[{"name":"Center of Reproductive Medicine, Maternity and Child Health Care of Guangxi Zhuang Autonomous Region","place":["Nanning, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi-Yun","family":"Liao","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Artificial Intelligence for Genetic Diseases of Long-dwelling Nationalities, Affiliated Hospital of Youjiang Medical University for 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