{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:02:31Z","timestamp":1791201751528,"version":"4.2.0"},"reference-count":56,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"\n Introduction<\/jats:title>\n \n Antibiotic resistance is a major concern in human and veterinary medicine, supporting the development of alternative topical products for companion animals. This study aimed to develop and evaluate essential oil (EO)-based dry shampoo formulations incorporating EOs from\n Cryptocarya alba<\/jats:italic>\n and\n Laureliopsis philippiana<\/jats:italic>\n as potential veterinary dermocosmetic platforms for canine skin care and complementary management of superficial pyoderma.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Starch-based dry shampoo prototypes containing\n C. alba<\/jats:italic>\n or\n L. philippiana<\/jats:italic>\n EOs were developed using corn starch, tapioca starch, or their mixtures. Magnesium stearate (MgS) was evaluated as a functional excipient, and two mixing protocols were compared. Optimized formulations were subjected to physicochemical characterization, thermal, mechanical, and 9-month stability assessments, and in vitro antibacterial testing against\n Staphylococcus pseudintermedius<\/jats:italic>\n . Preclinical dermal safety was evaluated in BALB\/c mice through macroscopic irritation scoring, body weight monitoring, and histological analysis. Subsequently, an exploratory, randomized, controlled, blinded, four-arm parallel-group study was conducted in 32 client-owned dogs with superficial pyoderma allocated to receive SLP, SCA, vehicle shampoo, or a chlorhexidine-based reference treatment for 21 days.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n MgS improved formulation homogeneity, fluidity, and reduced agglomeration, while the selected mixing protocol enhanced overall powder performance. The optimized formulations showed preliminary physical stability, although progressive changes in texture, fluidity, agglomeration tendency, and aroma were observed during storage. In vitro antibacterial activity was assay-dependent: no measurable inhibition zones were observed by agar diffusion, whereas serial dilution and viable-count assays showed concentration-dependent reductions in bacterial recovery, including effects associated with the vehicle formulation. No macroscopic or histological signs of dermal irritation were observed in mice. In dogs, the formulations were well tolerated under the evaluated conditions. Microbiological outcomes differed numerically among groups but not significantly; among the EO-containing formulations, SCA showed the most favorable exploratory profile, including culture negativity in 3\/8 dogs and the highest proportion of dogs reaching a non-significant bacterial burden.<\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n \n These findings support the feasibility of incorporating\n C. alba<\/jats:italic>\n and\n L. philippiana<\/jats:italic>\n EOs into starch-based dry shampoo prototypes and provide preliminary evidence of physical stability and dermal tolerability. However, the assay-dependent antibacterial response, alkaline formulation pH, limited batch replication, and exploratory clinical design preclude conclusions regarding clinical efficacy. Further studies should include formulation optimization, quantitative chemical stability assessment, dermal permeation studies, and larger randomized controlled clinical trials.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fvets.2026.1918882","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:34:55Z","timestamp":1791200095000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Stability and dermatological safety assessment of Cryptocarya alba (Peumo) and Laureliopsis philippiana (Tepa) essential oil-carrying dry shampoo formulations for dermal use in dogs"],"prefix":"10.3389","volume":"13","author":[{"given":"Mart\u00edn","family":"Varas","sequence":"first","affiliation":[{"name":"Laboratory of Bioactive Natural Products, School of Medicine, Center for Biomedical Research, Diego Portales University","place":["Santiago, Chile"]},{"name":"Department of Chemical Engineering, Biotechnology and Materials, Faculty of Physical and Mathematical Sciences, University of Chile","place":["Santiago, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Laboratory of Bioactive Natural Products, School of Medicine, Center for Biomedical Research, Diego Portales University","place":["Santiago, Chile"]},{"name":"Department of Chemical Engineering, Biotechnology and Materials, Faculty of Physical and Mathematical Sciences, University of Chile","place":["Santiago, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Rojas","sequence":"additional","affiliation":[{"name":"Laboratory of Bioactive Natural Products, School of Medicine, Center for Biomedical Research, Diego Portales University","place":["Santiago, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Ramos","sequence":"additional","affiliation":[{"name":"Laboratory of Bioactive Natural Products, School of Medicine, Center for Biomedical Research, Diego Portales University","place":["Santiago, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Bruna","sequence":"additional","affiliation":[{"name":"Laboratory of Bioactive Natural Products, School of Medicine, Center for Biomedical Research, Diego Portales University","place":["Santiago, Chile"]},{"name":"Hormone and Cancer Biology Laboratory, Institute of Experimental Medicine and Biology of Cuyo (IMBECU), CONICET CCT Mendoza\u2014National University of Cuyo (UNCuyo)","place":["Mendoza, Argentina"]},{"name":"Center of Odontological Research (CIO) From the Faculty of Odontology, National University of Cuyo (UNCuyo)","place":["Mendoza, Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Valenzuela-Barra","sequence":"additional","affiliation":[{"name":"Laboratory of Bioactive Natural Products, School of Medicine, Center for Biomedical Research, Diego Portales University","place":["Santiago, Chile"]},{"name":"Department of Pharmaceutical Sciences and Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile","place":["Santiago, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olosmira","family":"Correa","sequence":"additional","affiliation":[{"name":"Laboratory of Bioactive Natural Products, School of Medicine, Center for Biomedical Research, Diego Portales University","place":["Santiago, Chile"]},{"name":"Department of Pharmaceutical Sciences and Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile","place":["Santiago, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"D\u00edaz-Parra","sequence":"additional","affiliation":[{"name":"Laboratory of Bioactive Natural Products, School of Medicine, Center for Biomedical Research, Diego Portales University","place":["Santiago, Chile"]},{"name":"School of Biotechnology, Faculty of Sciences, Engineering and Technology, Mayor University","place":["Santiago, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Ahumada","sequence":"additional","affiliation":[{"name":"School of Biotechnology, Faculty of Sciences, Engineering and Technology, Mayor University","place":["Santiago, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Maturana","sequence":"additional","affiliation":[{"name":"Laboratory of Bioactive Natural Products, School of Medicine, Center for Biomedical Research, Diego Portales University","place":["Santiago, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Biotechnology and Materials, Faculty of Physical and Mathematical Sciences, University of Chile","place":["Santiago, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Abusleme","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Faculty of Medicine and Health Sciences, Mayor University","place":["Santiago, Chile"]},{"name":"Oftaderm Veterinary Clinic","place":["Santiago, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"Rivera","sequence":"additional","affiliation":[{"name":"Oftaderm Veterinary Clinic","place":["Santiago, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Olga","family":"Bargsted","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Faculty of Medicine and Health Sciences, Mayor University","place":["Santiago, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Siel","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Faculty of Medicine and Health Sciences, Mayor University","place":["Santiago, Chile"]},{"name":"Center for Biomedicine, Mayor University","place":["Santiago, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Bravo","sequence":"additional","affiliation":[{"name":"Laboratory of Bioactive Natural Products, School of Medicine, Center for Biomedical Research, Diego Portales University","place":["Santiago, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.3389\/fmicb.2016.01599","article-title":"Systematic review on 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