{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:08:34Z","timestamp":1789664914734,"version":"4.0.1"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study addresses the practical production problem of inferior cashmere quality in cashmere goats. We supplemented cysteamine (CS) in diets to regulate cashmere\u2011production\u2011related traits and explore its underlying nutritional regulatory pathways, so as to support the scientific and rational application of cysteamine in cashmere goat production.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Sixty healthy 18\u2011month\u2011old female Inner Mongolia cashmere goats were selected for this single\u2011factor randomized trial and randomly allocated into three groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f20 per group). The control group (CON) received basal diet; treatment groups were orally administrated cysteamine at 60\u202fmg\/kg body weight (BW)(LCS group) and 120\u202fmg\/kg BW (HCS group). Cashmere samples were collected from the designated trunk region. Fiber traits including diameter, staple length, breaking strength and elongation at break were measured, and fiber surface microstructure was observed by scanning electron microscopy (SEM). Skin tissues (n = 6 per group) were harvested for transcriptome and untargeted metabolomic sequencing to identify differentially expressed genes (DEGs) and differential metabolites (DEMs). KEGG enrichment and multi\u2011omics integrative analysis were further performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Dietary CS numerically improved cashmere yield, weight and scale height without statistical significance. The LCS treatment significantly increased straightened length, while staple length slightly decreased in the HCS group but remained higher than in CON. Initial cashmere diameter, strength and elongation at break showed no inter\u2011group differences; these three indicators increased after CS supplementation compared with baseline values. In total, 426 DEGs and 72 DEMs were detected, indicating obvious transcriptional and metabolic changes induced by CS. KEGG analysis highlighted divergence in the cAMP signaling pathway and thyroid hormone synthesis. DEMs were mainly enriched in lipid metabolism, organic acid metabolism and heterocyclic compound metabolism; L\u2011cysteine\u2011glutathione disulfide and \u03b1\u2011lipoic acid were key sulfur\u2011containing differential metabolites. Multi\u2011omics integration confirmed differences in lipid metabolism and cyclic nucleotide signaling pathways, with lipid\u2011related genes (\n                      <jats:italic>PLA2G2C, VDAC3, CHRM5, SYT4<\/jats:italic>\n                      ) and cyclic\u2011nucleotide\u2011related gene IL24 significantly up\u2011regulated in CS groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Multi\u2011omics results indicate that cysteamine may improve cashmere\u2011goat productive traits by providing endogenous organic sulfur sources, accumulating sulfur\u2011containing metabolic intermediates and coordinating hair\u2011follicle\u2011development\u2011related signaling pathways. This work supplies experimental evidence for cashmere fiber quality improvement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fvets.2026.1925080","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:15:06Z","timestamp":1789661706000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Deciphering cysteamine\u2019s impact on cashmere-producing traits of cashmere goats: a transcriptomic and metabolomic perspective"],"prefix":"10.3389","volume":"13","author":[{"given":"Tiecheng","family":"Wu","sequence":"first","affiliation":[{"name":"Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyu","family":"Guo","sequence":"additional","affiliation":[{"name":"Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyang","family":"Liu","sequence":"additional","affiliation":[{"name":"Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarengaowa","family":"Aierqing","sequence":"additional","affiliation":[{"name":"Alxa League Animal Husbandry and Veterinary Technology Extension Center","place":["Inner Mongolia, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leqi","family":"Yi","sequence":"additional","affiliation":[{"name":"Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"15142","DOI":"10.1038\/s41598-017-15516-0","article-title":"Identification of selection signals by large-scale whole-genome resequencing of cashmere goats","volume":"7","author":"Li","year":"2017","journal-title":"Sci Rep"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1111\/age.13053","article-title":"Genome-wide association study of fleece traits in Inner Mongolia cashmere goats","volume":"52","author":"Wang","year":"2021","journal-title":"Anim 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