{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:06:58Z","timestamp":1790172418228,"version":"4.1.0"},"reference-count":11,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>\n                    The Relative Severity Assessment (RELSA) score grades welfare severity based on the magnitude of multivariate deviations from a reference value. Many variables monitored during anaesthesia are homeostatic and become harmful when they leave the normal range in either direction. Building on the corridor concept of the PVS from human intensive care, we conducted a feasibility study to assess the application and behaviour of a corridor extension of RELSA in two canine anaesthesia datasets. Each homeostatic variable was given a normal band, and only its deviation was folded into the standard RELSA algorithm. Severity in this report denotes the number this algorithm returns, and that number has not been shown to represent clinical severity. We obtained two Beagle datasets, including one four-arm within-subject study, allowing a paired between-protocol comparison. This is an exploratory secondary analysis of existing data, with no\n                    <jats:italic>a priori<\/jats:italic>\n                    power calculation. Under the selected bands, the calculated score changed across the recorded anaesthetic course: low while awake, rising at the documented propofol induction, maintained, and resolving on recovery. The dominant departures were hypotension, hypothermia, and mild hypercapnia, sometimes coinciding with a single animal, though their magnitudes are band-dependent. Corridor RELSA produced a number that changed across the recorded anaesthetic course and represented bidirectional departures as a single continuous score. The between-protocol comparison is not interpreted as evidence about the protocols because the verdict it returns depends on the variable panel being scored. The approach is a domain extension and a small refinement of the human-ICU corridor concept.\n                  <\/jats:p>","DOI":"10.3389\/fvets.2026.1939921","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:33:30Z","timestamp":1790170410000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Corridor-based relative severity assessment of the canine anaesthetic course"],"prefix":"10.3389","volume":"13","author":[{"given":"Julia D.","family":"Kschonek","sequence":"first","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover","place":["Hannover, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine B. R.","family":"K\u00e4stner","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Analgesia, University of Veterinary Medicine Hannover","place":["Hannover, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp L. S.","family":"Ohland","sequence":"additional","affiliation":[{"name":"Institute for Laboratory Animal Science, Hannover Medical School","place":["Hannover, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Lutscher","sequence":"additional","affiliation":[{"name":"Institute for Laboratory Animal Science, Hannover Medical School","place":["Hannover, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger A.","family":"Volk","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover","place":["Hannover, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Talbot","sequence":"additional","affiliation":[{"name":"Institute for Laboratory Animal Science, Hannover Medical School","place":["Hannover, Germany"]},{"name":"Institute of Medical Statistics, RWTH Aachen University Hospital","place":["Aachen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1111\/j.1467-2995.2008.00397.x","article-title":"The risk of death: the confidential enquiry into perioperative small animal fatalities","volume":"35","author":"Brodbelt","year":"2008","journal-title":"Vet Anaesth Analg"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.vaa.2025.03.015","article-title":"The American College of Veterinary Anesthesia and Analgesia Small Animal Anesthesia and sedation monitoring guidelines 2025","volume":"52","author":"Bailey","year":"2025","journal-title":"Vet Anaesth Analg"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"937711","DOI":"10.3389\/fvets.2022.937711","article-title":"RELSA\u2014a multidimensional procedure for the comparative assessment of well-being and the quantitative determination of 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dogs","volume":"51","author":"K\u00e4stner","year":"2024","journal-title":"Vet Anaesth Analg"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"174949","DOI":"10.1016\/j.ejphar.2022.174949","article-title":"Tasipimidine\u2014the pharmacological profile of a novel orally active selective \u03b12A-adrenoceptor agonist","volume":"923","author":"Lehtim\u00e4ki","year":"2022","journal-title":"Eur J Pharmacol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1016\/S0140-6736(18)30479-3","article-title":"Mortality and morbidity in acutely ill adults treated with liberal versus conservative oxygen therapy (IOTA): a systematic review and meta-analysis","volume":"391","author":"Chu","year":"2018","journal-title":"Lancet"}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2026.1939921\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:33:31Z","timestamp":1790170411000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2026.1939921\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,23]]},"references-count":11,"alternative-id":["10.3389\/fvets.2026.1939921"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2026.1939921","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,23]]},"article-number":"1939921"}}