{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T05:20:23Z","timestamp":1787721623811,"version":"build-2784847793"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>\n                    Cadmium (Cd), a widely present environmental toxicant, can cause liver damage following chronic exposure. Although endoplasmic reticulum stress (ERS) and autophagy are known to be involved in Cd-induced liver injury, their molecular mechanisms remain incompletely understood. In this study, using an\n                    <jats:italic>in vitro<\/jats:italic>\n                    Cd exposure model and pharmacological interventions, we investigated the mechanisms through which Cd induces autophagy via ERS and its interplay with apoptosis. We found that Cd-induced autophagosome accumulation was linked to the activation of ERS pathways (PERK\/eIF2\u03b1\/ATF4, IRE1\u03b1\/JNK\/Beclin1, and ATF6). Furthermore, this accumulation was also attributable to Cd-induced impairment of autophagic degradation, as evidenced by p62 accumulation. In addition, Cd exposure activates FAM134B-dependent ER-phagy, which requires ERS regulation. Finally, the autophagy activator rapamycin alleviated apoptosis, whereas the inhibitor chloroquine exacerbated it. In summary, our findings reveal a mechanism through which Cd coordinately regulates hepatocyte fate via ER stress-mediated, FAM134B-dependent ER-phagy and canonical autophagy, offering novel therapeutic targets and theoretical foundations for mitigating Cd toxicity.\n                  <\/jats:p>","DOI":"10.3389\/fvets.2026.1939951","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T04:49:26Z","timestamp":1787719766000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Role of endoplasmic reticulum stress-mediated autophagy in cadmium-induced apoptosis in BRL-3A cells"],"prefix":"10.3389","volume":"13","author":[{"given":"Junbing","family":"Mao","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Henan University of Science and Technology","place":["Luoyang, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Ling","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Henan University of Science and Technology","place":["Luoyang, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Henan University of Science and Technology","place":["Luoyang, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaning","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Henan University of Science and Technology","place":["Luoyang, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Henan University of Science and Technology","place":["Luoyang, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Henan University of Science and Technology","place":["Luoyang, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jicang","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Henan University of Science and Technology","place":["Luoyang, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"7972","DOI":"10.1021\/la048866w","article-title":"Study of poly(N,N-dimethylacrylamide)\/CdS nanocomposite organic\/inorganic 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