{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:49:57Z","timestamp":1791355797868,"version":"4.3.1"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008992","name":"Yantai University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008992","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>\n                    This case report explored the clinical improvement and short-term tolerability of allogeneic adipose-derived mesenchymal stem cells (AD-MSCs) in the treatment of severe chronic kidney disease (CKD) in dogs. A 9-year-old female Pomeranian was diagnosed with chronic kidney disease (CKD) caused by acute kidney injury and, after conventional treatment failed, received intravenous infusion of AD-MSCs from healthy donor dogs. The AD-MSCs were aseptically collected, isolated, cultured, characterized, and subjected to microbiological safety testing, and were then administered intravenously at a dose of 3\u202f\u00d7\u202f10\n                    <jats:sup>6<\/jats:sup>\n                    cells\/kg every 2\u202fweeks for a total of four infusions, with dexamethasone premedication to reduce the risk of adverse reactions. Following AD-MSC administration and continued conventional care, reductions in serum creatinine and phosphorus and a downward trend in blood urea nitrogen were observed, along with improvements in body weight, body condition score, appetite, and mental status; no adverse events were observed. The results of this case suggest the feasibility and short-term tolerability of allogeneic AD-MSCs for severe CKD in dogs and provide a reference for clinical research on cell-based therapy for canine CKD.\n                  <\/jats:p>","DOI":"10.3389\/fvets.2026.1977920","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:53:31Z","timestamp":1791352411000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Allogeneic adipose-derived mesenchymal stem cells for severe chronic kidney disease in a dog"],"prefix":"10.3389","volume":"13","author":[{"given":"Yu","family":"Yu","sequence":"first","affiliation":[{"name":"College of Life Sciences, Yantai University","place":["Yantai, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemin","family":"Lv","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Yantai University","place":["Yantai, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Yantai University","place":["Yantai, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Yantai University","place":["Yantai, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[{"name":"OUR PET Hospital","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Yantai University","place":["Yantai, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhe","family":"Song","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Yantai University","place":["Yantai, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.cvsm.2010.09.004","article-title":"Chronic kidney disease in small animals","volume":"41","author":"Polzin","year":"2011","journal-title":"Vet Clin N Am Small Anim Pract"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1939-1676.1997.tb00074.x","article-title":"A retrospective case-control of acute renal failure in 99 dogs","volume":"11","author":"Vaden","year":"1997","journal-title":"J Vet Intern Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1111\/jvim.12090","article-title":"Chronic kidney 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