{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:36:48Z","timestamp":1766050608802,"version":"3.41.2"},"reference-count":9,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontierspartnerships.org"],"crossmark-restriction":true},"short-container-title":["J. Abdom. Wall Surg."],"abstract":"<jats:sec><jats:title>Purpose:<\/jats:title><jats:p>To describe and compare a peritoneal closure technique using cyanoacrylate glue (Glubran 2<jats:sup>\u00ae<\/jats:sup>, GEM, Cardiolink SL) with a microdroplet device (Glutack<jats:sup>\u00ae<\/jats:sup>, GEM, Cardiolink SL) in laparoscopic transabdominal preperitoneal repair (TAPP) of inguinal hernia with the routinely used barbed suture peritoneal closure (V-Lock 3.0, Covidien France).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods:<\/jats:title><jats:p>From January to August 2022, 60 patients undergoing TAPP repair for uni- or bilateral inguinal hernia were randomized into one of two groups. One using as mesh fixation and peritoneal closure the Glutack<jats:sup>\u00ae<\/jats:sup> device with Glubran 2<jats:sup>\u00ae<\/jats:sup> cyanoacrylate glue (Glu-close group) and the other using mesh fixation with cyanoacrylate and peritoneal closure with V-lock 3.0 (Sut-close group), with a follow-up of 12 months. Demographic variables, operative time, peritoneal closure time, main surgical findings and main intra- and postoperative complications were analyzed prospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>63 patients were included with no losses to follow-up. The mean operative time was 34\u00a0min (range 58.25) for the glu-close group and 40 (range 64.25) for the sut-close group, with no conversion (0%) for either group. The mean flap closure time was 1.18\u00a0min (SD 24 0.19) for the glu-close group and 3.24\u00a0min (SD 0.78) for the sut-close group, with statistically significant differences (<jats:italic>p<\/jats:italic> &amp;lt; 0.001). The intraoperative complication rate was 0 for the glu-close group and 0 for the sut-close group, with no significant difference. The median hospital stay was 0.8 days (range, 0\u20131) for both groups. The median duration of follow-up was 12 months and none had hernia recurrence. The postoperative VAS score at the first and second check-up at 1 month and 3 months was 2.83 (SD 1.341) and 0.60 (SD 0.621) in the sut-close group and 1.03 (0.984) and 0.24 (SD 0.435) in the glue-close group, with significant differences (<jats:italic>p<\/jats:italic> &amp;lt; 0.001 and <jats:italic>p<\/jats:italic> &amp;lt; 0.012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>The data demonstrated by the study are that the glue can be used safely to close the peritoneum and that the method provides a small, statistically significant but not clinically relevant reduction in the time to close the peritoneal flap, as well as in postoperative pain after surgery in short and medium term.<\/jats:p><\/jats:sec>","DOI":"10.3389\/jaws.2024.12562","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T04:12:30Z","timestamp":1714536750000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Closure of the Peritoneum in Laparoscopic Transabdominal Preperitoneal Inguinal Hernia Repair (TAPP) With Cyanoacrylate Glue in a Microdroplet Device: A Single Surgeon Prospective Comparison vs. Barbed Suture"],"prefix":"10.3389","volume":"3","author":[{"given":"Juan Manuel","family":"Su\u00e1rez-Grau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Navarro-Morales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Tallon-Aguilar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvador","family":"Morales-Conde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Javier","family":"Padillo-Ruiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,5,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1007\/s10029-015-1431-0","article-title":"Comparison of Peritoneal Closure Techniques in Laparoscopic Transabdominal Preperitoneal Inguinal Hernia Repair: A Prospective 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Repair","volume":"211","author":"Antoniou","year":"2016","journal-title":"Am J Surg"},{"key":"B5","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1007\/s10029-018-1861-6","article-title":"Laparoscopic Transabdominal Preperitoneal (TAPP) Groin Hernia Repair Using N-Butyl-2-Cyanoacrylate (Liquiband\u00aeFix8\u2122) for Mesh Fixation and Peritoneal Closure: Learning Experience During Introduction Into Clinical Practice","volume":"23","author":"Wilson","year":"2019","journal-title":"Hernia"},{"key":"B6","doi-asserted-by":"publisher","first-page":"4077","DOI":"10.1007\/s00464-017-5454-8","article-title":"Mesh Fixation Methods and Chronic Pain After Transabdominal Preperitoneal (TAPP) Inguinal Hernia Surgery: A Comparison Between Fibrin Sealant and Tacks","volume":"31","author":"Andresen","year":"2017","journal-title":"Surg Endosc"},{"key":"B7","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1097\/01.sla.0000245832.59478.c6","article-title":"Use of Human Fibrin Glue (Tissucol) Versus Staples for Mesh Fixation in Laparoscopic Transabdominal Preperitoneal Hernioplasty: A Prospective, Randomized Study","volume":"245","author":"Lovisetto","year":"2007","journal-title":"Ann Surg"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e24","DOI":"10.1097\/SLE.0000000000000797","article-title":"Laparoscopic Transabdominal Preperitoneal (TAPP) Inguinal Hernia Repair Using Fibrin Glue for Fixation of the Mesh and Peritoneum Closure","volume":"30","author":"Ielpo","year":"2020","journal-title":"Surg Laparosc Endosc Percutan Tech"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1007\/s00464-011-2025-2","article-title":"Staple Versus Fibrin Glue Fixation in Laparoscopic Total Extraperitoneal Repair of Inguinal Hernia: A Systematic Review and Meta-Analysis","volume":"26","author":"Kaul","year":"2012","journal-title":"Surg Endosc"}],"container-title":["Journal of Abdominal Wall 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