{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:37:28Z","timestamp":1753893448796,"version":"3.41.2"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontierspartnerships.org"],"crossmark-restriction":true},"short-container-title":["J. pharm. pharm. sci."],"abstract":"<jats:p>The present study evaluated the rational prescription of linezolid, the prevalence of thrombocytopenia, and major drug interactions in patients with cardiovascular diseases. We conducted a retrospective cross-sectional study on linezolid-treated patients at Shahid Chamran Heart Hospital in Isfahan from March 21, 2021, to March 20, 2022. Our research involved 132 patients who received linezolid. We reported 43.18% of linezolid prescriptions as irrational. Linezolid-induced thrombocytopenia is more common than previous studies, with a prevalence of 47.9%. We found a significant relationship between thrombocytopenia and the concomitant use of aspirin. The duration of treatment was identified as predicting factor for linezolid-induced thrombocytopenia. Moreover, the prevalence of interactions in the X and D categories was determined. Serotonergic and catecholamine medications were associated with 56.1% and 47.7% medication interactions, respectively. Our study found a high prevalence of linezolid-induced thrombocytopenia among patients with cardiovascular diseases. Based on this study, physicians should focus more closely on prescribing linezolid to patients with cardiovascular diseases. In addition to following rational antibiotic use, this susceptible group is also at an elevated risk of side effects (thrombocytopenia) and medication interactions.<\/jats:p>","DOI":"10.3389\/jpps.2024.13343","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T04:15:03Z","timestamp":1726114503000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the rational prescription of linezolid, the prevalence of thrombocytopenia and major drug interactions in patients with cardiovascular diseases: are there any cautions?"],"prefix":"10.3389","volume":"27","author":[{"given":"Mehrnoush","family":"Dianatkhah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamed","family":"Salami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasool","family":"Soltani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Hosseini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,9,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1007\/s10096-017-2900-4","article-title":"Assessment of linezolid prescriptions in three French hospitals","volume":"36","author":"Dentan","year":"2017","journal-title":"Eur J Clin Microbiol & Infect Dis"},{"key":"B2","doi-asserted-by":"publisher","first-page":"530","DOI":"10.3390\/antibiotics10050530","article-title":"Clinical use and adverse drug reactions of linezolid: a retrospective study in four Belgian hospital centers","volume":"10","author":"Thirot","year":"2021","journal-title":"Antibiotics"},{"key":"B3","doi-asserted-by":"publisher","first-page":"39576","DOI":"10.52965\/001c.39576","article-title":"Clinically relevant drug interactions with monoamine oxidase inhibitors","volume":"10","author":"Edinoff","year":"2022","journal-title":"Health Psychol Res"},{"key":"B4","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1111\/bcpt.13123","article-title":"Risk factors for linezolid\u2010induced thrombocytopenia in patients without haemato\u2010oncologic diseases","volume":"124","author":"Choi","year":"2019","journal-title":"Basic & Clin Pharmacol & Toxicol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e895","DOI":"10.1161\/cir.0000000000001063","article-title":"2022 AHA\/ACC\/HFSA guideline for the management of heart failure: a report of the American college of cardiology\/American heart association joint committee on clinical practice guidelines","volume":"145","author":"Heidenreich","year":"2022","journal-title":"Circulation"},{"key":"B6","doi-asserted-by":"publisher","first-page":"3075","DOI":"10.1093\/eurheartj\/ehv319","article-title":"ESC guidelines for the management of infective endocarditis: the task force for the management of infective endocarditis of the European Society of Cardiology (ESC) endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM)","volume":"36","author":"Habib","year":"2015","journal-title":"Eur Heart J"},{"key":"B7","doi-asserted-by":"publisher","first-page":"S27","DOI":"10.1086\/511159","article-title":"Infectious Diseases Society of America\/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults","volume":"44","author":"Mandell","year":"2007","journal-title":"Clin Infect Dis"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e61","DOI":"10.1093\/cid\/ciw353","article-title":"Management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 clinical practice guidelines by the Infectious Diseases Society of America and the American Thoracic Society","volume":"63","author":"Kalil","year":"2016","journal-title":"Clin Infect Dis"},{"key":"B9","doi-asserted-by":"publisher","first-page":"4160","DOI":"10.1182\/blood-2012-07-443051","article-title":"Predictive value of the 4Ts scoring system for heparin-induced thrombocytopenia: a systematic review and meta-analysis","volume":"120","author":"Cuker","year":"2012","journal-title":"Blood"},{"key":"B10","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1111\/bcp.14965","article-title":"Effect of renal function on the risk of thrombocytopaenia in patients receiving linezolid therapy: a systematic review and meta\u2010analysis","volume":"88","author":"Shi","year":"2022","journal-title":"Br J Clin Pharmacol"},{"key":"B11","unstructured":"Drug decision support with UpToDate lexidrug"},{"key":"B12","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1097\/ta.0b013e3182a74b70","article-title":"Vancomycin and nephrotoxicity; 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