{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T06:15:01Z","timestamp":1763532901844,"version":"3.45.0"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontierspartnerships.org"],"crossmark-restriction":true},"short-container-title":["J. Pharm. Pharm. Sci."],"abstract":"<jats:sec>\n                    <jats:title>Background\/objectives<\/jats:title>\n                    <jats:p>Optimal nutrition in very low birth weight (VLBW) infants is associated with improved clinical outcomes. When parenteral nutrition (PN) with a marketing authorisation is not appropriate, hospital pharmacies can prepare more suitable PN preparation. This corresponds to standard preparations (i.e., available at any time with a fixed composition) or individualised ones (i.e., available after a period of prescription, preparation, and pharmaceutical control). In France, 12 standard formulas to be compounded were proposed by a national consortium in 2018. The objective of the present study was to evaluate whether individualised PN preparations ordered in our hospital are substitutable by one of the 12 standard formulas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All PN prescriptions for VLBW infants made in 2021 in our hospital were retrospectively extracted. For each prescription, the theoretical intakes that an infant would have received if a standard preparation had been administered were calculated. Standard and individualised preparations were compared using the Mann-Whitney U test for each component. Secondly, the relative difference between the expected intakes and effectively intakes was calculated for each component.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results\/Discussion<\/jats:title>\n                    <jats:p>Over the study period, 1708 prescriptions were identified (corresponding to 1708\u00a0PN individualised preparations). Most infants were extremely low birth weight infants. Based on the methods of comparison, none of the 12 standard formulas fitted with targeted intakes achieved with individualised PN preparations ordered, whereas prescriptions did fit with international guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The study highlights how it is difficult to establish nationally standard PN formulas for VLBW infants; the development of local standard formulas seems therefore relevant.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/jpps.2025.15310","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T06:10:14Z","timestamp":1763532614000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Standard formulas and individualised parenteral nutrition preparations in very low birth weight infants"],"prefix":"10.3389","volume":"28","author":[{"given":"Laurie","family":"Dez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Ha\u00ffs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Leboucher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romain","family":"Garreau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Charles","family":"Picaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Briot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"j3448","DOI":"10.1136\/bmj.j3448","article-title":"Neurodevelopmental outcome at 2 years for preterm children born at 22 to 34 weeks\u2019 gestation in France in 2011: EPIPAGE-2 cohort study","volume":"358","author":"Pierrat","year":"2017","journal-title":"BMJ"},{"key":"B2","doi-asserted-by":"publisher","first-page":"n741","DOI":"10.1136\/bmj.n741","article-title":"Neurodevelopmental outcomes at age 5 among children born preterm: EPIPAGE-2 cohort study","volume":"373","author":"Pierrat","year":"2021","journal-title":"BMJ"},{"key":"B3","doi-asserted-by":"publisher","first-page":"S25","DOI":"10.1016\/j.earlhumdev.2011.12.024","article-title":"Early lipid supply and neurological development at one year in very low birth weight (VLBW) preterm infants","author":"dit Trolli","year":"2012","journal-title":"Early Hum Dev"},{"key":"B4","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1097\/MCO.0000000000000270","article-title":"Nutrition in the preterm infant: what\u2019s new?","volume":"19","author":"Cleminson","year":"2016","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1016\/j.clnu.2018.06.948","article-title":"ESPGHAN\/ESPEN\/ESPR\/CSPEN guidelines on pediatric parenteral nutrition: fluid and electrolytes","volume":"37","author":"Jochum","year":"2018","journal-title":"Clin Nutr"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.1016\/j.clnu.2018.06.955","article-title":"ESPGHAN\/ESPEN\/ESPR\/CSPEN guidelines on pediatric parenteral nutrition: standard versus individualized parenteral nutrition","volume":"37","author":"Riskin","year":"2018","journal-title":"Clin Nutr"},{"key":"B7","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1111\/apa.12092","article-title":"Extremely low birthweight infants: how neonatal intensive care unit teams can reduce postnatal malnutrition and prevent growth retardation","volume":"102","author":"Lo\u00ffs","year":"2013","journal-title":"Acta Paediatr"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e64","DOI":"10.1111\/j.1651-2227.2011.02443.x","article-title":"Reduction in postnatal cumulative nutritional deficit and improvement of growth in extremely preterm infants","volume":"101","author":"Senterre","year":"2012","journal-title":"Acta Paediatr"},{"key":"B9","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1177\/0148607107031005441","article-title":"ASPEN statement on parenteral nutrition standardization","volume":"31","author":"Kochevar","year":"2007","journal-title":"J Parenter Enteral Nutr"},{"key":"B10","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1007\/s11096-009-9281-4","article-title":"Comparison of two types of TPN prescription methods in preterm neonates","volume":"31","author":"Skouroliakou","year":"2009","journal-title":"Pharm World Sci"},{"key":"B11","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1007\/s00431-006-0124-1","article-title":"Assessment of implementation of a standardized parenteral formulation for early nutritional support of very preterm infants","volume":"165","author":"Lenclen","year":"2006","journal-title":"Eur J Pediatr"},{"key":"B12","article-title":"Nutrition parent\u00e9rale en n\u00e9onatologie: M\u00e9thode Recommandations pour la pratique clinique","year":"2018"},{"key":"B13","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41430-020-0669-5","article-title":"Parenteral nutrition: a call to action for harmonization of policies to increase patient safety","volume":"75","author":"Gallagher","year":"2021","journal-title":"Eur J Clin Nutr"},{"key":"B14","doi-asserted-by":"publisher","first-page":"2360","DOI":"10.1016\/j.clnu.2018.06.950","article-title":"ESPGHAN\/ESPEN\/ESPR\/CSPEN guidelines on pediatric parenteral nutrition: calcium, phosphorus and magnesium","volume":"37","author":"Mihatsch","year":"2018","journal-title":"Clin Nutr"},{"key":"B15","doi-asserted-by":"publisher","first-page":"2324","DOI":"10.1016\/j.clnu.2018.06.946","article-title":"ESPGHAN\/ESPEN\/ESPR\/CSPEN guidelines on pediatric parenteral nutrition: lipids","volume":"37","author":"Lapillonne","year":"2018","journal-title":"Clin Nutr"},{"key":"B16","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.1016\/j.clnu.2018.06.945","article-title":"ESPGHAN\/ESPEN\/ESPR\/CSPEN guidelines on pediatric parenteral nutrition: amino acids","volume":"37","author":"Van Goudoever","year":"2018","journal-title":"Clin Nutr"},{"key":"B17","first-page":"1","volume-title":"Neonatal parenteral nutrition","year":"2020"},{"key":"B18","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s12887-020-1958-9","article-title":"Standardised neonatal parenteral nutrition formulations \u2013 australasian neonatal parenteral nutrition consensus update 2017","volume":"20","author":"Bolisetty","year":"2020","journal-title":"BMC Pediatr"},{"key":"B19","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.3390\/nu11092167","article-title":"Attainment targets for protein intake using standardised, concentrated and individualised neonatal parenteral nutrition regimens","volume":"11","author":"Morgan","year":"2019","journal-title":"Nutrients"},{"key":"B20","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/1471-2431-14-48","article-title":"Standardised neonatal parenteral nutrition formulations \u2013 an Australasian group consensus 2012","volume":"14","author":"Bolisetty","year":"2014","journal-title":"BMC Pediatr"},{"key":"B21","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1111\/apa.17461","article-title":"Most babies born at a French hospital before 26 weeks survived with good outcomes","volume":"114","author":"Abello","year":"2025","journal-title":"Acta Paediatr"},{"key":"B22","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1007\/s00431-023-05319-z","article-title":"Neurodevelopment at 24 months corrected age in extremely preterm infants treated with dexamethasone alternatives during the late postnatal period: a cohort study","volume":"183","author":"Melan","year":"2023","journal-title":"Eur J Pediatr"},{"key":"B23","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1186\/s12887-014-0309-0","article-title":"Improved nutrient intake following implementation of the consensus standardised parenteral nutrition formulations in preterm neonates \u2013 a before-after intervention study","volume":"14","author":"Bolisetty","year":"2014","journal-title":"BMC Pediatr"},{"key":"B24","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1177\/0884533617715868","article-title":"Parenteral nutrition errors and potential errors reported over the past 10 years","volume":"32","author":"Guenter","year":"2017","journal-title":"Nutr Clin Pract"},{"key":"B25","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.clnu.2017.02.002","article-title":"Safety of parenteral nutrition in newborns: results from a nationwide prospective cohort study","volume":"37","author":"Lapillonne","year":"2018","journal-title":"Clin Nutr"},{"key":"B26","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1016\/j.clnu.2010.04.004","article-title":"Long-term physico-chemical stability of standard parenteral nutritions for neonates","volume":"29","author":"Bouchoud","year":"2010","journal-title":"Clin Nutr"},{"key":"B27","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1136\/ejhpharm-2018-001788","article-title":"Quality and safety of parenteral nutrition for newborn and preterm infants as an on-ward preparation","volume":"27","author":"Sommer","year":"2020","journal-title":"Eur J Hosp Pharm"},{"key":"B28","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.2146\/ajhp070681","article-title":"Microbial contamination of syringes during preparation: the direct influence of environmental cleanliness and risk manipulations on end-product quality","volume":"66","author":"Stucki","year":"2009","journal-title":"Am J Health-System Pharm"}],"container-title":["Journal of Pharmacy &amp; Pharmaceutical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.frontierspartnerships.org\/articles\/10.3389\/jpps.2025.15310\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T06:10:15Z","timestamp":1763532615000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontierspartnerships.org\/articles\/10.3389\/jpps.2025.15310\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,19]]},"references-count":28,"alternative-id":["10.3389\/jpps.2025.15310"],"URL":"https:\/\/doi.org\/10.3389\/jpps.2025.15310","relation":{},"ISSN":["1482-1826"],"issn-type":[{"value":"1482-1826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,19]]},"article-number":"15310"}}