{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:25:54Z","timestamp":1777890354710,"version":"3.51.4"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Oncol. Rev."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Treatment of childhood cancer is associated with a substantial risk of life-threatening complications that may require admission to a pediatric intensive care unit (PICU). Data describing clinical characteristics, indications for intensive care, and outcomes in this population remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective, single-center study analyzed all pediatric oncology patients who required PICU admission because of acute clinical deterioration during cancer treatment between 2010 and 2022. Fifty-one children treated at the Department of Pediatric Oncology, Hematology, and Chemotherapy of the Upper Silesian Child Health Centre (Medical University of Silesia, Katowice, Poland) were included. Demographic data, underlying malignancies, reasons for PICU admission, laboratory findings, therapeutic interventions, and outcomes were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 61 PICU hospitalizations occurred, including repeated admissions in nine patients with leukemia. Most children were diagnosed with hematological malignancies, followed by brain tumors and extracranial solid tumors. The leading indications for PICU admission were septic shock, respiratory failure, and cardiopulmonary failure, accounting for 75.4% of cases. Cardiovascular support with catecholamines was required in 52.5% of patients, and renal replacement therapy was initiated in 18.0%. Both catecholamine use and renal replacement therapy were independently associated with a significantly increased risk of mortality. Life-threatening complications requiring intensive care occurred most frequently during leukemia treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Severe treatment-related complications requiring intensive care are common in pediatric oncology, particularly among children with hematological malignancies. Septic shock during neutropenia remains the predominant cause of PICU admission. Early identification of clinical deterioration and clearly defined criteria for timely PICU referral\u2014especially in cases of septic shock\u2014may improve survival outcomes in this vulnerable population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/or.2026.1699224","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:36:05Z","timestamp":1777613765000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical characteristics and outcomes of pediatric cancer patients admitted to the intensive care unit during treatment: a retrospective analysis"],"prefix":"10.3389","volume":"20","author":[{"given":"Joanna","family":"Sordyl","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Pediatric Oncology, Hematology and Chemotherapy Unit, Upper Silesian Child Health Centre, Medical University of Silesia","place":["Katowice, Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Damps","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Upper Silesian Child Health Centre, Medical University of Silesia","place":["Katowice, Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Skowron-Kandzia","sequence":"additional","affiliation":[{"name":"Prenatal Diagnostic and Genetic Clinic, Medical University of Silesia","place":["Zabrze, Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"Baranowska","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pediatric Oncology, Hematology and Chemotherapy Unit, Upper Silesian Child Health Centre, Medical University of Silesia","place":["Katowice, Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Mizia-Malarz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pediatric Oncology, Hematology and Chemotherapy Unit, Upper Silesian Child Health Centre, Medical University of Silesia","place":["Katowice, Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e301","DOI":"10.1016\/S1470-2045(17)30186-9","article-title":"International incidence of childhood cancer, 2001-10: a population-based registry study","volume":"18","author":"Steliarova-Foucher","year":"2017","journal-title":"Lancet Oncol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S1470-2045(13)70548-5","article-title":"Childhood cancer survival in Europe 1999-2007: results of EUROCARE-5\u2013a population-based study","volume":"15","author":"Gatta","year":"2014","journal-title":"Lancet Oncol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1097\/01.mph.0000168724.19025.a4","article-title":"Hospital resource utilization in childhood cancer","volume":"27","author":"Rosenman","year":"2005","journal-title":"J Pediatr Hematol Oncol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"252","DOI":"10.24953\/turkjped.2020.02.011","article-title":"Outcomes and prognostic factors for pediatric cancer patients admitted to an intensive care unit in a university hospital","volume":"62","author":"Dursun","year":"2020","journal-title":"Turk J Pediatr"},{"key":"B5","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s11845-010-0634-8","article-title":"Indications for admission, treatment and improved outcome of paediatric haematology\/oncology patients admitted to a tertiary paediatric ICU","volume":"180","author":"Owens","year":"2011","journal-title":"Ir J Med Sci"},{"key":"B6","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1097\/MPH.0b013e3181a330ef","article-title":"Prognostic factors in pediatric cancer patients admitted to the pediatric intensive care unit","volume":"31","author":"Dursun","year":"2009","journal-title":"J Pediatr Hematol Oncol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1007\/s00431-005-1695-y","article-title":"Assessing the risk of mortality in paediatric cancer patients admitted to the paediatric intensive care unit: a novel risk score?","volume":"164","author":"Meyer","year":"2005","journal-title":"Eur J Pediatr"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.5005\/jp-journals-10071-23693","article-title":"Critically ill pediatric oncology patients: what the intensivist needs to know? 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