{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:48:11Z","timestamp":1782312491153,"version":"3.54.5"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["ssph-journal.org"],"crossmark-restriction":true},"short-container-title":["Public Health Rev."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This review was conducted with the aim of assessing the pooled prevalence of congenital anomalies and its predictors among newborns in Ethiopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The relevant studies were identified by electronic database searching methods. All statistical analyses were carried out with STATA\u2122 Version-14 software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 22 studies were included in this review. The pooled prevalence of congenital anomalies was 21.25 per 1,000 newborns. Age of the mother 35 years and above (POR = 3.29, 95% CI: 1.59\u20136.82) absence of formal education among mothers (POR = 1.35, 95% CI:1.12\u20131.63), maternal cigarate smoking (POR = 2.98, 95% CI:1.56\u20135.67), alcoholic drinking (POR = 2.66, 95% CI:1.28\u20135.51), chat chewing (POR = 3.37, 95% CI:1.57\u20137.21), no folic acid supplementation (POR = 4.29, 95% CI:2.35\u20137.83), pesticide exposure (POR = 3.23, 95% CI: 2.02\u20135.16), medication use during pregnancy (POR = 4.37, 95% CI:2.11\u20139.06), maternal chronic illness (POR = 3.76, 95% CI:1.72\u20138.20), preterm (POR = 2.35, 95% CI: 1.59\u20133.47), multiple pregnancy (POR = 3.66, 95% CI:1.99\u20136.71), low birth weight (POR = 5.46, 95% CI: 4.41\u20136.75) were identified as the predictors of congenital anomalies among newborns in Ethiopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Relatively high burden of congenital anomalies were detected. Hence, strategies to minimize substance use, exposure to pesticide and medication, and to improve folic acid supplementation during pregnancy should be encouraged.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/phrs.2026.1608833","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T06:10:09Z","timestamp":1771827009000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["A Silent Epidemic of Congenital Anomalies and Its Predictors Among Newborns in Ethiopia: A Systematic Review and Meta-Analysis"],"prefix":"10.3389","volume":"47","author":[{"given":"Mitku Mammo","family":"Taderegew","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Asrat Woldeyes Health Science Campus, Debre Berhan University","place":["Debre Berhan, Ethiopia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alemayehu","family":"Wondie","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Medicine and Health Sciences, Wolkite University","place":["Wolkite, Ethiopia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feredegn Talargia","family":"Belete","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Asrat Woldeyes Health Science Campus, Debre Berhan University","place":["Debre Berhan, Ethiopia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wondosen","family":"Debebe","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Medicine and Health Sciences, Wollo University","place":["Wollo, Ethiopia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lemlemu","family":"Maru","sequence":"additional","affiliation":[{"name":"Department of Human Physiology, School of Medicine, College of Medicine and Health Science, University of Gondar","place":["Gondar, Ethiopia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gashaw Garedew","family":"Woldeamanuel","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, College of Medicine and Health Sciences, Wolkite University","place":["Wolkite, Ethiopia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"B1","volume-title":"Birth Defects Surveillance: A Manual for Programme Managers","year":"2014"},{"key":"B2","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1136\/bmj.332.7536.256-b","volume":"332","year":"2006","journal-title":"BMJ"},{"key":"B3","doi-asserted-by":"publisher","first-page":"2354002","DOI":"10.1080\/16549716.2024.2354002","article-title":"Action Against Birth Defects: If Not Now, When?","volume":"17","author":"Strong","year":"2024","journal-title":"Glob Health Action"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/01.xps.0000522257.34234.7d","article-title":"Challenges of Congenital Malformations: An African Perspective","volume":"14","author":"Emordi","year":"2018","journal-title":"Ann Pediatr Surg"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1111171","DOI":"10.3389\/fpubh.2023.1111171","article-title":"Challenges of Having a Child with Congenital Anomalies in Saudi Arabia: A Qualitative Exploration of Mothers' Experience","volume":"11","author":"Alqarawi","year":"2023","journal-title":"Front Public Health"},{"key":"B6","unstructured":"2023"},{"key":"B7","unstructured":"Healthy Newborn Network. 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