{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T10:12:29Z","timestamp":1775211149734,"version":"3.50.1"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T00:00:00Z","timestamp":1623974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["por-journal.com"],"crossmark-restriction":true},"short-container-title":["Pathol. Oncol. Res."],"abstract":"<jats:p><jats:bold>Purpose:<\/jats:bold> The Myc family, especially <jats:italic>C-MYC<\/jats:italic> and <jats:italic>MYCL1<\/jats:italic>, has been found involved in small-cell lung carcinoma (SCLC). Identification of the frequency of C-MYC and MYCL1 expression among SCLC patients may help to identify potential targets for therapeutic intervention. Our aim was to detect <jats:italic>MYCL1<\/jats:italic> amplification, L-Myc and c-Myc expression, and investigate clinicopathological characteristics and survival status in patients with surgically resected SCLC.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold><jats:italic>MYCL1<\/jats:italic> amplification was detected using fluorescence <jats:italic>in situ<\/jats:italic> hybridization (FISH), while L-Myc and c-Myc protein expressions were determined using immunohistochemistry (IHC) in the primary tumors of 46 resected SCLC patients.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Among the 46 evaluated specimens, <jats:italic>MYCL1<\/jats:italic> amplification was identified in 3\/46 cases (6.5%). One of the positive cases was <jats:italic>MYCL1<\/jats:italic> gene amplification combined with fusion. 3\/46 (6.5%) was positive for L-myc protein expression, and 4\/46 (8.7%) was positive for c-Myc protein expression.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Our study firstly multidimensional explored the expression of <jats:italic>MYCL1<\/jats:italic> amplification, L-Myc and c-Myc protein and investigated clinicopathological characteristics and survival status in patients with surgically resected SCLC, which makes a contribution to subsequent research and therapeutic strategies.<\/jats:p>","DOI":"10.3389\/pore.2021.1609775","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T04:11:16Z","timestamp":1623989476000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["MYCL1 Amplification and Expression of L-Myc and c-Myc in Surgically Resected Small-Cell Lung 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