{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T17:15:57Z","timestamp":1778260557128,"version":"3.51.4"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T00:00:00Z","timestamp":1639440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["por-journal.com"],"crossmark-restriction":true},"short-container-title":["Pathol. Oncol. Res."],"abstract":"<jats:p>Small cell carcinoma of hypercalcemic type (SCCOHT) is a rare gynaecological neoplasm, originating mostly in the ovaries. Cervical origin of this very aggressive malignancy with unknown histogenesis is an extremely rare condition, without published management recommendations. Alterations in <jats:italic>SMARCA4<\/jats:italic> gene are supposed to play the major role in SCCOHT oncogenesis and their identification is crucial for the diagnosis. Adequate genetic counselling of the patients and their families seems to be of great importance. Optimal management and treatment approaches are not known yet but may extremely influence the prognosis of young female patients that suffer from this very resistant disease. Nowadays, a translational research seems to be the key for the further diagnostic and treatment strategies of SCCOHT. The purpose of the case report is to provide practical information and useful recommendations on the diagnosis, management, and treatment of SMARCA4-deficient carcinoma of the uterine cervix resembling SCCOHT.<\/jats:p>","DOI":"10.3389\/pore.2021.1610003","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T04:11:25Z","timestamp":1639455085000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["SMARCA4-Deficient Carcinoma of Uterine Cervix Resembling SCCOHT\u2014Case Report"],"prefix":"10.3389","volume":"27","author":[{"given":"Igor","family":"Sir\u00e1k","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Laco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hana","family":"Vo\u0161mikov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loren K.","family":"Mell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda G.","family":"Herrera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1ria","family":"\u0160enke\u0159\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan","family":"Vo\u0161mik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,12,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.ygyno.2018.02.004","article-title":"Small Cell Cancers of the Female Genital Tract: Molecular and Clinical Aspects","volume":"149","author":"Patibandla","year":"2018","journal-title":"Gynecol Oncol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1002\/1097-0142(19820101)49:1<188:aid-cncr2820490137>3.0.co;2-d","article-title":"Small Cell Carcinoma of the Ovary with Hypercalcemia: A Report of Eleven Cases","volume":"49","author":"Richard Dickersin","year":"1982","journal-title":"Cancer"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1097\/00000478-199411000-00004","article-title":"Small Cell Carcinoma of the Ovary, Hypercalcemic Type","volume":"18","author":"Young","year":"1994","journal-title":"Am J Surg Pathol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"56","DOI":"10.2350\/15-04-1624-CR.1","article-title":"Small Cell Carcinoma of the Ovary, Hypercalcemic Type: Report of a Bilateral Case in a Teenager Associated with SMARCA4 Germline Mutation","volume":"19","author":"Lavrut","year":"2016","journal-title":"Pediatr Dev Pathol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s10689-016-9957-6","article-title":"The Hereditary Nature of Small Cell Carcinoma of the Ovary, Hypercalcemic Type: Two New Familial Cases","volume":"16","author":"Witkowski","year":"2017","journal-title":"Fam Cancer"},{"key":"B6","doi-asserted-by":"publisher","first-page":"531","DOI":"10.5858\/2005-129-531-sccoto","article-title":"Small Cell Carcinoma of the Ovary with Hypercalcemia and Ectopic Parathyroid Hormone Production","volume":"129","author":"Chen","year":"2005","journal-title":"Arch Pathol Labor Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1002\/1097-0142(19940401)73:7<1878:AID-CNCR2820730717>3.0.CO;2-D","article-title":"Human Parathyroid Hormone\u2010related Protein in Ovarian Small Cell Carcinoma. 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