{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:18:11Z","timestamp":1774927091387,"version":"3.50.1"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["por-journal.com"],"crossmark-restriction":true},"short-container-title":["Pathol. Oncol. Res."],"abstract":"<jats:p>Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy is increasingly performed in patients with advanced cancer in the abdomen. This treatment prolongs survival for some patients but is known to have a substantial rate of complications. Choosing patients for this procedure can be difficult, and no clear guidelines exist. Muscle mass is a general measure of a patient\u2019s wellness, meaning that patients with low muscle mass for their body weight tend to have more complications from treatment and overall do worse. We evaluated muscle mass prior to surgery in our Cytoreductive surgery\/hyperthermic intraperitoneal chemotherapy population to assess how many patients have low muscle mass and the impact on outcomes, such as length of hospital stay, complications and survival. We find that about 25% of our patient population has low muscle mass, and low muscle mass is associated with a higher burden of cancer and shorter survival. We were able to evaluate muscle mass in a small number of patients after surgery, expecting to find decreased muscle mass in all the patients after a complex operation and long recovery. In fact, none of the patients had low muscle mass, including those who were low prior to surgery.<\/jats:p>","DOI":"10.3389\/pore.2021.638857","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T04:11:17Z","timestamp":1630296677000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["The Impact of Sarcopenia in Patients with Peritoneal Surface Disease"],"prefix":"10.3389","volume":"27","author":[{"given":"Aubrey","family":"Juris","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Taylor-Gehman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brianna","family":"Spencer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Schaefer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colette","family":"Pameijer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,8,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3891","DOI":"10.1245\/s10434-016-5360-7","article-title":"Sarcopenia is associated with chemotherapy toxicity in patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis from colorectal cancer","volume":"23","author":"Chemama","year":"2016","journal-title":"Ann Surg Oncol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"3625","DOI":"10.1245\/s10434-015-4429-z","article-title":"Skeletal muscle depletion is associated with severe postoperative complications in patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis of colorectal cancer","volume":"22","author":"van Vugt","year":"2015","journal-title":"Ann Surg Oncol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1007\/978-1-4613-1247-5_23","article-title":"Clinical research methodologies in diagnosis and staging of patients with peritoneal carcinomatosis","volume":"82","author":"Jacquet","year":"1996","journal-title":"Cancer Treat Res"},{"key":"B4","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.hpb.2016.06.009","article-title":"Fast and accurate liver volumetry prior to hepatectomy","volume":"18","author":"Lodewick","year":"2016","journal-title":"Hpb"},{"key":"B5","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1016\/j.clnu.2019.03.014","article-title":"Prognostic significance of sarcopenia and skeletal muscle mass change during preoperative chemoradiotherapy in locally advanced rectal cancer","volume":"39","author":"Chung","year":"2020","journal-title":"Clin Nutr"},{"key":"B6","doi-asserted-by":"publisher","first-page":"e172319","DOI":"10.1001\/jamaoncol.2017.2319","article-title":"Association of systemic inflammation and sarcopenia with survival in nonmetastatic colorectal cancer: results from the C SCANS study","volume":"3","author":"Cespedes Feliciano","year":"2017","journal-title":"JAMA Oncol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J Am Stat Assoc"},{"key":"B8","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1093\/ageing\/afy106","article-title":"The prevalence of sarcopenia in community-dwelling older adults, an exploration of differences between studies and within definitions: a systematic review and meta-analyses","volume":"48","author":"Mayhew","year":"2019","journal-title":"Age Ageing"},{"key":"B9","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1093\/advances\/nmy065","article-title":"The impact of dairy protein intake on muscle mass, muscle strength, and physical performance in middle-aged to older adults with or without existing sarcopenia: a systematic review and meta-analysis","volume":"10","author":"Hanach","year":"2019","journal-title":"Adv Nutr"},{"key":"B10","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1002\/bjs.7823","article-title":"Body composition and outcome in patients undergoing resection of colorectal liver metastases","volume":"99","author":"van Vledder","year":"2012","journal-title":"Br J Surg"},{"key":"B11","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1038\/bjc.2012.350","article-title":"Sarcopenia is associated with postoperative infection and delayed recovery from colorectal cancer resection surgery","volume":"107","author":"Lieffers","year":"2012","journal-title":"Br J Cancer"},{"key":"B12","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/1475-2891-9-69","article-title":"Pretreatment serum albumin as a predictor of cancer survival: a systematic review of the epidemiological literature","volume":"9","author":"Gupta","year":"2010","journal-title":"Nutr J"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e0139749","DOI":"10.1371\/journal.pone.0139749","article-title":"Skeletal muscle depletion predicts the prognosis of patients with advanced pancreatic cancer undergoing palliative chemotherapy, independent of body mass index","volume":"10","author":"Choi","year":"2015","journal-title":"PLoS One"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1002\/ajh.24465","article-title":"Impact of sarcopenia on treatment tolerance in United States veterans with diffuse large B-cell lymphoma treated with CHOP-based chemotherapy","volume":"91","author":"Xiao","year":"2016","journal-title":"Am J Hematol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1097\/spc.0000000000000382","article-title":"Preservation of muscle mass as a strategy to reduce the toxic effects of cancer chemotherapy on body composition","volume":"12","author":"Pin","year":"2018","journal-title":"Curr Opin Support Palliat Care"},{"key":"B16","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1007\/s00520-017-3875-5","article-title":"Eight-week, multimodal exercise counteracts a progress of chemotherapy-induced peripheral neuropathy and improves balance and strength in metastasized colorectal cancer patients: a randomized controlled trial","volume":"26","author":"Zimmer","year":"2018","journal-title":"Support Care Cancer"}],"container-title":["Pathology and Oncology Research"],"original-title":[],"link":[{"URL":"https:\/\/www.por-journal.com\/articles\/10.3389\/pore.2021.638857\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T04:11:18Z","timestamp":1630296678000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.por-journal.com\/articles\/10.3389\/pore.2021.638857\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,30]]},"references-count":16,"alternative-id":["10.3389\/pore.2021.638857"],"URL":"https:\/\/doi.org\/10.3389\/pore.2021.638857","relation":{},"ISSN":["1532-2807"],"issn-type":[{"value":"1532-2807","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,30]]},"article-number":"638857"}}