{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T18:06:19Z","timestamp":1759514779643,"version":"3.41.2"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:00:00Z","timestamp":1617840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["por-journal.com"],"crossmark-restriction":true},"short-container-title":["Pathol. Oncol. Res."],"abstract":"<jats:p>Non-Hodgkin lymphomas comprise a heterogeneous group of malignancies, with a wide scope of clinical, radiological and histological presentations. In this paper, a case is presented of a 59-year-old white male with an infraorbital follicular B-cell lymphoma, which appeared as a painless mass in the left cheek. The lymphoma achieved spontaneous remission five and a half months after his diagnostic incision biopsy. The literature is reviewed, focusing on this rare site of presentation and spontaneous remission. In literature, only four cases have been reported with a follicular B-cell lymphoma of the cheek or infraorbital region, and only 26 cases of spontaneous remission of an extracranial non-Hodgkin lymphoma in the head and neck region have been described. To the authors\u2019 best knowledge, this is the first time spontaneous remission of an infraorbital follicular lymphoma could be observed. The nature of the processes inducing spontaneous remission remains obscure. It is important to recognize this phenomenon as this might prevent unnecessary treatment.<\/jats:p>","DOI":"10.3389\/pore.2021.642433","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T11:09:13Z","timestamp":1617880153000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: Spontaneous Remission of an Infraorbital Follicular B-Cell Lymphoma: Case Report and Review of the Literature"],"prefix":"10.3389","volume":"27","author":[{"given":"Maxime","family":"Peeters","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joris","family":"Geusens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9deric","family":"Van der Cruyssen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucienne","family":"Michaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"de Leval","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Tousseyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Vandenberghe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantinus","family":"Politis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,4,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"54","DOI":"10.5581\/1516-8484.20120015","article-title":"Follicular lymphoma","volume":"34","author":"Luminari","year":"2011","journal-title":"Rev Bras Hematol Hemoter"},{"key":"B2","doi-asserted-by":"publisher","first-page":"43","DOI":"10.4103\/0976-9668.82318","article-title":"Immunity over inability: the spontaneous regression of cancer","volume":"2","author":"Jessy","year":"2011","journal-title":"J Nat Sci Biol Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.anndiagpath.2005.09.020","article-title":"Extranodal lymphomas of the head and neck","volume":"9","author":"Vega","year":"2005","journal-title":"Ann Diagn Pathol"},{"key":"B4","first-page":"4","article-title":"Lymphoma of cheek: a case report","author":"Malaguarnera","year":"2012","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"B5","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1002\/1097-0142(19860801)58:3<699::AID-CNCR2820580317>3.0.CO;699-E","article-title":"Lymphomas of salivary glands","volume":"58","author":"Gleeson","year":"1986","journal-title":"Cancer"},{"key":"B6","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.clon.2012.02.004","article-title":"Pathology of extra-nodal non hodgkin lymphomas","volume":"24","author":"Wright","year":"2012","journal-title":"Clin Oncol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/j.1365-2559.2004.01804.x","article-title":"Extranodal follicular lymphoma: a clinicopathological and genetic analysis of 15 cases arising at non-cutaneous extranodal sites","volume":"44","author":"Goodlad","year":"2004","journal-title":"Histopathology"},{"key":"B8","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1148\/radiology.188.3.8351335","article-title":"Facial lymph nodes: normal and abnormal CT appearance","volume":"13","author":"Tart","year":"1993","journal-title":"Radiology"},{"key":"B9","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1097\/PRS.0b013e3181fed511","article-title":"Variations in the lymphatic drainage pattern of the head and neck: further anatomic studies and clinical implications","volume":"127","author":"Pan","year":"2011","journal-title":"Plast Reconstr Surg"},{"key":"B10","doi-asserted-by":"publisher","first-page":"172","DOI":"10.14312\/2399-8172.2016-3","article-title":"The forgotten lymph nodes: review of the superficial head and neck lymphatic system","volume":"19","author":"Bou-Assaly","year":"2016","journal-title":"J Radiol Imaging"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1182\/blood.V104.11.1375.1375","article-title":"Extranodal follicular lymphoma - 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