{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:19:06Z","timestamp":1777792746809,"version":"3.51.4"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["por-journal.com"],"crossmark-restriction":true},"short-container-title":["Pathol. Oncol. Res."],"abstract":"<jats:p>Adult brainstem gliomas are rare central nervous system tumors that represent a heterogeneous group of tumors. Somatic <jats:italic>IDH<\/jats:italic> mutations are uncommon in adult brainstem gliomas and there are few relevant clinical studies. Here, we reported five patients with <jats:italic>IDH1<\/jats:italic> mutations associated with brainstem gliomas, including four cases of <jats:italic>IDH1<\/jats:italic> R132H mutations and one case of R132G mutation. All patients were treated with focal intensity-modulated radiation therapy (IMRT) with concurrent temozolomide (TMZ). One patient died, one relapsed, and three survived to date. All these cases carried a pathogenic variant of <jats:italic>TP53<\/jats:italic>, among whom 1 harbored <jats:italic>ATRX<\/jats:italic> mutation and 1 had <jats:italic>H3K27M<\/jats:italic> mutation. Moreover, we also found some genes related to a worse prognosis, such as <jats:italic>CDK4\/6<\/jats:italic> amplification. These findings demonstrate that the specific characteristics of <jats:italic>IDH<\/jats:italic>-mutant brainstem gliomas should be considered in diagnostic workflows to make therapeutic regimens and improve the prognosis.<\/jats:p>","DOI":"10.3389\/pore.2022.1610408","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T04:12:00Z","timestamp":1659586320000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Case Report: Clinicopathological and Genetic Features of IDH-Mutant Brainstem Glioma in Adults: Report of Five Cases"],"prefix":"10.3389","volume":"28","author":[{"given":"Jiangfen","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyao","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoqun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junjie","family":"Zhen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Furong","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linbo","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"iv1","DOI":"10.1093\/neuonc\/nov189","article-title":"CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2008-2012","volume":"17","author":"Ostrom","year":"2015","journal-title":"Neuro Oncol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2799","DOI":"10.1002\/cncr.29920","article-title":"Adult Brainstem Gliomas","volume":"122","author":"Eisele","year":"2016","journal-title":"Cancer"},{"key":"B3","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s00415-008-0589-0","article-title":"Natural History and Management of Brainstem Gliomas in Adults. 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