{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:30:01Z","timestamp":1787027401093,"version":"build-2736575974"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T00:00:00Z","timestamp":1654732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["por-journal.com"],"crossmark-restriction":true},"short-container-title":["Pathol. Oncol. Res."],"abstract":"<jats:p>Circular RNA (circRNA) is stable and abundant in exosomes as a potential biomarker for the diagnosis and prognosis of tumor. In this study, cancer specific exosomal circRNAs were identified through circRNA microarray, and 58 circRNAs were significantly upregulated in cancer cells derived exosomes. Then 60 patients with newly diagnosed gastric cancer (GC), 30 chronic gastritis patients and 30 healthy subjects were enrolled for further clinical validation. We detected that hsa_circ_0015286 was remarkably highly expressed in GC tissue, plasma and cancer cells compared with normal controls. Results of ROC curve analysis showed that the area under curve (AUC) of hsa_circ_0015286, CEA and CA 19-9 was 0.778, 0.673, and 0.665, respectively. The combined detection of three indicators had the highest AUC (0.843). Exosomal hsa_circ_0015286 expression was closely associated with tumor size, TNM stage and lymph node metastasis. The expression level of exosomal hsa_circ_0015286 in GC patients decreased significantly after surgery. Overall survival of patients with low hsa_circ_0015286 expression was longer than those with high expression. Our data demonstrated that exosomal hsa_circ_0015286 might be a promising noninvasive biomarker for the diagnosis and prognosis evaluation of GC.<\/jats:p>","DOI":"10.3389\/pore.2022.1610446","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T00:11:09Z","timestamp":1654733469000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":42,"title":["Plasma Exosomal hsa_circ_0015286 as a Potential Diagnostic and Prognostic Biomarker for Gastric Cancer"],"prefix":"10.3389","volume":"28","author":[{"given":"Peiming","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijie","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanhu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peipei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA A Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","first-page":"115","DOI":"10.3322\/caac.21338","article-title":"Cancer Statistics in China, 2015","volume":"66","author":"Chen","year":"2016","journal-title":"CA: A Cancer J Clinicians"},{"key":"B3","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/s0140-6736(20)31288-5","article-title":"Gastric Cancer","volume":"396","author":"Smyth","year":"2020","journal-title":"The Lancet"},{"key":"B4","first-page":"367","volume-title":"The Biology, Function, and Biomedical Applications of Exosomes","author":"Kalluri","year":"2020"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1016\/j.cell.2016.01.043","article-title":"Communication by Extracellular Vesicles: Where We Are and where We Need to Go","volume":"164","author":"Tkach","year":"2016","journal-title":"Cell"},{"key":"B6","doi-asserted-by":"publisher","first-page":"6480","DOI":"10.1158\/0008-5472.can-17-0994","article-title":"The Biology of Cancer Exosomes: Insights and New Perspectives","volume":"77","author":"Ruivo","year":"2017","journal-title":"Cancer Res"},{"key":"B7","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1158\/1078-0432.ccr-17-2007","article-title":"Liquid Biopsies Using Plasma Exosomal Nucleic Acids and Plasma Cell-free DNA Compared with Clinical Outcomes of Patients with Advanced Cancers","volume":"24","author":"M\u00f6hrmann","year":"2018","journal-title":"Clin Cancer Res"},{"key":"B8","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.canlet.2018.01.011","article-title":"Circular RNA: An Emerging Non-coding RNA as a Regulator and Biomarker in Cancer","volume":"418","author":"Chen","year":"2018","journal-title":"Cancer Lett"},{"key":"B9","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1038\/cr.2015.82","article-title":"Circular RNA Is Enriched and Stable in Exosomes: a Promising Biomarker for Cancer Diagnosis","volume":"25","author":"Li","year":"2015","journal-title":"Cell Res"},{"key":"B10","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.omtn.2020.06.008","article-title":"Emerging Function and Clinical Significance of Exosomal circRNAs in Cancer","volume":"21","author":"Wang","year":"2020","journal-title":"Mol Ther - 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