{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:40:01Z","timestamp":1791906001957,"version":"4.3.4"},"reference-count":80,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T00:00:00Z","timestamp":1674086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013064","name":"Key Research and Development Program of Jiangxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013064","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["por-journal.com"],"crossmark-restriction":true},"short-container-title":["Pathol. Oncol. Res."],"abstract":"<jats:p>NOP56 is a highly conserved nucleolar protein. Amplification of the intron GGCCTG hexanucleotide repeat sequence of the <jats:italic>NOP56<\/jats:italic> gene results in spinal cerebellar ataxia type 36 (SCA36). NOP56 contains an N-terminal domain, a coiled-coil domain, and a C-terminal domain. Nucleolar protein NOP56 is significantly abnormally expressed in a number of malignant tumors, and its mechanism is different in different tumors, but its regulatory mechanism in most tumors has not been fully explored. NOP56 promotes tumorigenesis in some cancers and inhibits tumorigenesis in others. In addition, NOP56 is associated with methylation in some tumors, suggesting that NOP56 has the potential to become a tumor-specific marker. This review focuses on the structure, function, related signaling pathways, and role of NOP56 in the progression of various malignancies, and discusses the progression of NOP56 in neurodegenerative and other diseases.<\/jats:p>","DOI":"10.3389\/pore.2023.1610884","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T04:11:49Z","timestamp":1674101509000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["The roles of NOP56 in cancer and SCA36"],"prefix":"10.3389","volume":"29","author":[{"given":"Shimin","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongdong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sicheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"7088","DOI":"10.1128\/mcb.17.12.7088","article-title":"Nucleolar KKE\/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesis","volume":"17","author":"Gautier","year":"1997","journal-title":"Mol Cell Biol"},{"key":"B2","unstructured":"GeneCards NOP562022"},{"key":"B3","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1126\/science.288.5465.517","article-title":"Homologs of small nucleolar RNAs in Archaea","volume":"288","author":"Omer","year":"2000","journal-title":"Science"},{"key":"B4","doi-asserted-by":"publisher","first-page":"10193","DOI":"10.3390\/ijms221910193","article-title":"Emerging functions for snoRNAs and snoRNA-derived fragments","volume":"22","author":"Wajahat","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B5","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1017\/s1355838200992446","article-title":"Box C\/D snoRNA-associated proteins: Two pairs of evolutionarily ancient proteins and possible links to replication and transcription","volume":"6","author":"Newman","year":"2000","journal-title":"RNA"},{"key":"B6","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/s41556-021-00653-6","article-title":"A PRC2-independent function for EZH2 in regulating rRNA 2\u2032-O methylation and IRES-dependent translation","volume":"23","author":"Yi","year":"2021","journal-title":"Nat Cell Biol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e0170160","DOI":"10.1371\/journal.pone.0170160","article-title":"Expression profiling of ribosome biogenesis factors reveals nucleolin as a novel potential marker to predict outcome in AML patients","volume":"12","author":"Marcel","year":"2017","journal-title":"PLoS One"},{"key":"B8","doi-asserted-by":"publisher","first-page":"7607","DOI":"10.1080\/21655979.2022.2048772","article-title":"RNA-seq and integrated network analysis reveals the hub genes and key pathway of paclitaxel inhibition on Adriamycin resistant diffuse large B cell lymphoma cells","volume":"13","author":"Hong","year":"2022","journal-title":"Bioengineered"},{"key":"B9","doi-asserted-by":"publisher","first-page":"3519","DOI":"10.1038\/onc.2013.338","article-title":"Burkitt\u2019s lymphoma-associated c-Myc mutations converge on a dramatically altered target gene response and implicate Nol5a\/Nop56 in oncogenesis","volume":"33","author":"Cowling","year":"2014","journal-title":"Oncogene"},{"key":"B10","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s13046-022-02240-5","article-title":"Metabolic synthetic lethality by targeting NOP56 and mTOR in KRAS-mutant lung cancer","volume":"41","author":"Yang","year":"2022","journal-title":"J Exp Clin Cancer Res"},{"key":"B11","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.ajhg.2011.05.015","article-title":"Expansion of intronic GGCCTG hexanucleotide repeat in NOP56 causes SCA36, a type of spinocerebellar ataxia accompanied by motor neuron involvement","volume":"89","author":"Kobayashi","year":"2011","journal-title":"Am J Hum Genet"},{"key":"B12","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/S1474-4422(04)00737-9","article-title":"Autosomal dominant cerebellar ataxias: Clinical features, genetics, and pathogenesis","volume":"3","author":"Sch\u00f6ls","year":"2004","journal-title":"Lancet Neurol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1212\/WNL.0b013e318260436f","article-title":"Clinical features of SCA36: A novel spinocerebellar ataxia with motor neuron involvement (asidan)","volume":"79","author":"Ikeda","year":"2012","journal-title":"Neurology"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1093\/brain\/aws069","article-title":"Costa da morte\u201d ataxia is spinocerebellar ataxia 36: Clinical and genetic characterization","volume":"135","author":"Garc\u00eda-Murias","year":"2012","journal-title":"Brain"},{"key":"B15","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.nrl.2014.11.005","article-title":"Spinocerebellar ataxia 36 (SCA36): \u00abCosta da morte ataxia","volume":"32","author":"Arias","year":"2017","journal-title":"Neurologia"},{"key":"B16","unstructured":"National Center for Biotechnology information2022"},{"key":"B17","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.molcel.2018.08.017","article-title":"Box C\/D snoRNP Autoregulation by a cis-Acting snoRNA in the NOP56 Pre-mRNA","volume":"72","author":"Lykke-Andersen","year":"2018","journal-title":"Mol Cell"},{"key":"B18","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1083\/jcb.201404160","article-title":"Proteomic and 3D structure analyses highlight the C\/D box snoRNP assembly mechanism and its control","volume":"207","author":"Bizarro","year":"2014","journal-title":"J Cell Biol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/j.molcel.2010.07.025","article-title":"A proteomic screen for nucleolar SUMO targets shows SUMOylation modulates the function of Nop5\/Nop58","volume":"39","author":"Westman","year":"2010","journal-title":"Mol Cell"},{"key":"B20","doi-asserted-by":"publisher","first-page":"e50684","DOI":"10.15252\/embr.202050684","article-title":"The deubiquitinase USP36 promotes snoRNP group SUMOylation and is essential for ribosome biogenesis","volume":"22","author":"Ryu","year":"2021","journal-title":"EMBO Rep"},{"key":"B21","doi-asserted-by":"publisher","first-page":"6148","DOI":"10.1093\/nar\/gkg794","article-title":"A role for c-Myc in the regulation of ribosomal RNA processing","volume":"31","author":"Schlosser","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"B22","doi-asserted-by":"publisher","first-page":"8839","DOI":"10.1158\/0008-5472.CAN-09-1970","article-title":"The role of myc-induced protein synthesis in cancer","volume":"69","author":"Ruggero","year":"2009","journal-title":"Cancer Res"},{"key":"B23","doi-asserted-by":"publisher","first-page":"3784","DOI":"10.1093\/nar\/29.18.3784","article-title":"AdoMet-dependent methylation, DNA methyltransferases and base flipping","volume":"29","author":"Cheng","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"B24","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/s0959-440x(02)00391-3","article-title":"SAM (dependent) I AM: The S-adenosylmethionine-dependent methyltransferase fold","volume":"12","author":"Martin","year":"2002","journal-title":"Curr Opin Struct Biol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1016\/j.cell.2016.04.047","article-title":"Coexisting liquid phases underlie nucleolar subcompartments","volume":"165","author":"Feric","year":"2016","journal-title":"Cell"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1261\/rna.068312.118","article-title":"The multistructural forms of box C\/D ribonucleoprotein particles","volume":"24","author":"Yu","year":"2018","journal-title":"RNA"},{"key":"B27","doi-asserted-by":"publisher","first-page":"5094","DOI":"10.1093\/nar\/gkaa247","article-title":"Functional organization of box C\/D RNA-guided RNA methyltransferase","volume":"48","author":"Yang","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"B28","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1261\/rna.077396.120","article-title":"High-resolution structure of eukaryotic Fibrillarin interacting with Nop56 amino-terminal domain","volume":"27","author":"H\u00f6fler","year":"2021","journal-title":"RNA"},{"key":"B29","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1038\/emboj.2011.128","article-title":"CRM1 controls the composition of nucleoplasmic pre-snoRNA complexes to licence them for nucleolar transport: CRM1 controls transport and assembly of snoRNPs","volume":"30","author":"Pradet-Balade","year":"2011","journal-title":"EMBO J"},{"key":"B30","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1038\/nchembio.1997","article-title":"The solution structural ensembles of RNA kink-turn motifs and their protein complexes","volume":"12","author":"Shi","year":"2016","journal-title":"Nat Chem Biol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"5289","DOI":"10.1073\/pnas.082101999","article-title":"In vitro reconstitution and activity of a C\/D box methylation guide ribonucleoprotein complex","volume":"99","author":"Omer","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B32","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1261\/rna.7223405","article-title":"Conserved spacing between the box C\/D and C\u2032\/D\u2032 RNPs of the archaeal box C\/D sRNP complex is required for efficient 2\u2032-O-methylation of target RNAs","volume":"11","author":"Tran","year":"2005","journal-title":"RNA"},{"key":"B33","doi-asserted-by":"publisher","first-page":"13808","DOI":"10.1073\/pnas.0905128106","article-title":"Structural organization of box C\/D RNA-guided RNA methyltransferase","volume":"106","author":"Ye","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"B34","doi-asserted-by":"publisher","first-page":"19418","DOI":"10.1074\/jbc.M111.323253","article-title":"Structurally conserved Nop56\/58 N-terminal domain facilitates archaeal box C\/D ribonucleoprotein-guided methyltransferase activity","volume":"287","author":"Gagnon","year":"2012","journal-title":"J Biol Chem"},{"key":"B35","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/nature09688","article-title":"Structural basis for site-specific ribose methylation by box C\/D RNA protein complexes","volume":"469","author":"Lin","year":"2011","journal-title":"Nature"},{"key":"B36","doi-asserted-by":"publisher","first-page":"3930","DOI":"10.1093\/emboj\/cdg368","article-title":"Efficient RNA 2\u2019-O-methylation requires juxtaposed and symmetrically assembled archaeal box C\/D and C\u2019\/D\u2019 RNPs","volume":"22","author":"Tran","year":"2003","journal-title":"EMBO J"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/j.jmb.2006.07.091","article-title":"Assembly of the archaeal box C\/D sRNP can occur via alternative pathways and requires temperature-facilitated sRNA remodeling","volume":"362","author":"Gagnon","year":"2006","journal-title":"J Mol Biol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1080\/15476286.2016.1243646","article-title":"Assembly and trafficking of box C\/D and H\/ACA snoRNPs","volume":"14","author":"Massenet","year":"2017","journal-title":"RNA Biol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"5068","DOI":"10.1093\/nar\/gkw386","article-title":"An updated human snoRNAome","volume":"44","author":"Jorjani","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"B40","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1074\/jbc.M704209200","article-title":"Characterization of a short isoform of human Tgs1 hypermethylase associating with small nucleolar ribonucleoprotein core proteins and produced by limited proteolytic processing","volume":"283","author":"Girard","year":"2008","journal-title":"J Biol Chem"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0898-6568(99)00071-6","article-title":"The p38 signal transduction pathway: Activation and function","volume":"12","author":"Ono","year":"2000","journal-title":"Cell Signal"},{"key":"B42","doi-asserted-by":"publisher","first-page":"2723","DOI":"10.1101\/gad.9.22.2723","article-title":"Rel\/NF-kappa B\/I kappa B family: Intimate tales of association and dissociation","volume":"9","author":"Verma","year":"1995","journal-title":"Genes Dev"},{"key":"B43","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.fsi.2021.11.011","article-title":"NOP56 negatively regulates MyD88-mediated NF-\u03baB signaling in miiuy croaker, Miichthys miiuy","volume":"120","author":"Ren","year":"2022","journal-title":"Fish Shellfish Immunol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/s41392-021-00791-1","article-title":"The JAK\/STAT signaling pathway: From bench to clinic","volume":"6","author":"Hu","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1534\/genetics.113.155945","article-title":"Evidence for tissue-specific JAK\/STAT target genes in Drosophila optic lobe development","volume":"195","author":"Wang","year":"2013","journal-title":"Genetics"},{"key":"B46","doi-asserted-by":"publisher","first-page":"2577","DOI":"10.1158\/1535-7163.MCT-21-0201","article-title":"Characterization of KRAS mutation subtypes in non\u2013small cell lung cancer","volume":"20","author":"Judd","year":"2021","journal-title":"Mol Cancer Ther"},{"key":"B47","doi-asserted-by":"publisher","first-page":"184","DOI":"10.12122\/j.issn.1673-4254.2021.02.04","article-title":"Effect of piRNA NU13 in regulating biological behaviors of human Wilms tumor cells in vitro","volume":"41","author":"Zhang","year":"2021","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-439016\/v1","article-title":"PiRNA MW557525 promotes the vitality and pluripotency of piwil2-iCSCs by regulating NOP56","author":"Zhang","year":"2021"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1038\/onc.2013.89","article-title":"Elevated snoRNA biogenesis is essential in breast cancer","volume":"33","author":"Su","year":"2014","journal-title":"Oncogene"},{"key":"B50","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.ajpath.2020.09.010","article-title":"Expression, localization, and function of the nucleolar protein BOP1 in prostate cancer progression","volume":"191","author":"Vellky","year":"2021","journal-title":"Am J Pathol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"107","DOI":"10.17219\/acem\/112608","article-title":"Analysis of the rRNA methylation complex components in pediatric B-cell precursor acute lymphoblastic leukemia: A pilot study","volume":"29","author":"Ussowicz","year":"2020","journal-title":"Adv Clin Exp Med"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/br.2021.1484","article-title":"Association between promoter methylation and gene expression of CGB3 and NOP56 in HPV-infected cervical cancer cells","volume":"16","author":"Singh","year":"2022","journal-title":"Biomed Rep"},{"key":"B53","doi-asserted-by":"publisher","first-page":"2472","DOI":"10.3390\/ijms16022472","article-title":"Promoter hypermethylation of tumour suppressor genes as potential biomarkers in colorectal cancer","volume":"16","author":"Ng","year":"2015","journal-title":"Int J Mol Sci"},{"key":"B54","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/s41575-019-0230-y","article-title":"Epigenetics of colorectal cancer: Biomarker and therapeutic potential","volume":"17","author":"Jung","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"3968","DOI":"10.1002\/jcp.26176","article-title":"Comparison of genome\u2010wide analysis techniques to DNA methylation analysis in human cancer","volume":"233","author":"Soozangar","year":"2018","journal-title":"J Cell Physiol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"65514","DOI":"10.18632\/oncotarget.11804","article-title":"c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinoma","volume":"7","author":"Ciribilli","year":"2016","journal-title":"Oncotarget"},{"key":"B57","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1186\/s13071-016-1815-8","article-title":"Developmental piRNA profiles of the invasive vector mosquito Aedes albopictus","volume":"9","author":"Liu","year":"2016","journal-title":"Parasit Vectors"},{"key":"B58","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/s12943-019-1052-9","article-title":"The emerging role of the piRNA\/piwi complex in cancer","volume":"18","author":"Liu","year":"2019","journal-title":"Mol Cancer"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10238-017-0467-0","article-title":"DNA methylation profiles in cancer diagnosis and therapeutics","volume":"18","author":"Pan","year":"2018","journal-title":"Clin Exp Med"},{"key":"B60","doi-asserted-by":"publisher","first-page":"347","DOI":"10.3389\/fgene.2020.00347","article-title":"DNA methylation and hydroxymethylation in cervical cancer: Diagnosis, prognosis and treatment","volume":"11","author":"Zhu","year":"2020","journal-title":"Front Genet"},{"key":"B61","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21387","article-title":"Cancer statistics, 2017","volume":"71","author":"Siegel","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"B62","doi-asserted-by":"publisher","first-page":"301","DOI":"10.3892\/ijo.2020.5039","article-title":"CDH1 and SNAI1 are regulated by E7 from human papillomavirus types 16 and 18","volume":"57","author":"Rosendo-Chalma","year":"2020","journal-title":"Int J Oncol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1111\/cas.12761","article-title":"Human papillomavirus type 16 E7 oncoprotein mediates CCNA1 promoter methylation","volume":"106","author":"Chalertpet","year":"2015","journal-title":"Cancer Sci"},{"key":"B64","first-page":"40","article-title":"The expressions of DNA methyltransferase 1 (DNMT1) and cyclin A1 (CCNA1) in cervical carcinogenesis","volume":"12","author":"Cao","year":"2019","journal-title":"Int J Clin Exp Pathol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1038\/s41416-022-01868-6","article-title":"Clinical applications and utility of cell-free DNA-based liquid biopsy analyses in cervical cancer and its precursor lesions","volume":"127","author":"Herbst","year":"2022","journal-title":"Br J Cancer"},{"key":"B66","doi-asserted-by":"publisher","first-page":"5517","DOI":"10.1038\/s41598-021-84837-y","article-title":"A gene module identification algorithm and its applications to identify gene modules and key genes of hepatocellular carcinoma","volume":"11","author":"Zhang","year":"2021","journal-title":"Sci Rep"},{"key":"B67","doi-asserted-by":"publisher","first-page":"601693","DOI":"10.3389\/pore.2021.601693","article-title":"Identification of biomarkers related to immune cell infiltration in hepatocellular carcinoma using gene Co-expression network","volume":"27","author":"Zhou","year":"2021","journal-title":"Pathol Oncol Res"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-1962830\/v1","article-title":"Dissecting novel tumor antigens and immune subtypes guided mRNA vaccine development for HBV related-hepatocellular carcinoma","author":"Li","year":"2022"},{"key":"B69","doi-asserted-by":"publisher","first-page":"2929","DOI":"10.3390\/ijms20122929","article-title":"Next-generation sequencing in acute lymphoblastic leukemia","volume":"20","author":"Coccaro","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B70","doi-asserted-by":"publisher","first-page":"626","DOI":"10.3390\/ijms23020626","article-title":"Telomere and telomerase-associated proteins in endometrial carcinogenesis and cancer-associated survival","volume":"23","author":"Button","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B71","doi-asserted-by":"publisher","first-page":"2326","DOI":"10.3390\/ijms18112326","article-title":"Whole blood mRNA expression-based prognosis of metastatic renal cell carcinoma","volume":"18","author":"Giridhar","year":"2017","journal-title":"Int J Mol Sci"},{"key":"B72","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/s13205-021-02987-2","article-title":"Scouting for common genes in the heterogenous hypoxic tumor microenvironment and their validation in glioblastoma","volume":"11","author":"Bhushan","year":"2021","journal-title":"3 Biotech"},{"key":"B73","unstructured":"Expansion of intronic GGCCTG hexanucleotide repeat in NOP56 causes SCA36, a type of spinocerebellar ataxia accompanied by motor neuron involvement - PubMed2022"},{"key":"B74","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1111\/cge.12706","article-title":"Genetic and clinical analysis of spinocerebellar ataxia type 36 in Mainland China","volume":"90","author":"Zeng","year":"2016","journal-title":"Clin Genet"},{"key":"B75","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3389\/fnmol.2016.00055","article-title":"Function over form: Modeling groups of inherited neurological conditions in zebrafish","volume":"9","author":"Kozol","year":"2016","journal-title":"Front Mol Neurosci"},{"key":"B76","doi-asserted-by":"publisher","first-page":"1814","DOI":"10.3390\/biomedicines10081814","article-title":"A nop56 zebrafish loss-of-function model exhibits a severe neurodegenerative phenotype","volume":"10","author":"Quelle-Regaldie","year":"2022","journal-title":"Biomedicines"},{"key":"B77","doi-asserted-by":"publisher","first-page":"12430","DOI":"10.1038\/s41598-019-48835-5","article-title":"Spontaneous mutations of the Zpld1 gene in mice cause semicircular canal dysfunction but do not impair gravity receptor or hearing functions","volume":"9","author":"Vijayakumar","year":"2019","journal-title":"Scientific Rep"},{"key":"B78","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1179\/1743132813Y.0000000196","article-title":"Early and selective reduction of NOP56 (Asidan) and RNA processing proteins in the motor neuron of ALS model mice","volume":"35","author":"Miyazaki","year":"2013","journal-title":"Neurol Res"},{"key":"B79","doi-asserted-by":"publisher","first-page":"e15083","DOI":"10.1097\/MD.0000000000015083","article-title":"Identification of aberrantly methylated differentially expressed genes in age-related macular degeneration","volume":"98","author":"Xu","year":"2019","journal-title":"Medicine"},{"key":"B80","doi-asserted-by":"publisher","first-page":"933721","DOI":"10.3389\/fimmu.2022.933721","article-title":"Revealing the key MSCs niches and pathogenic genes in influencing cep homeostasis: A conjoint analysis of single-cell and WGCNA","volume":"13","author":"Li","year":"2022","journal-title":"Front Immunol"}],"container-title":["Pathology and Oncology Research"],"original-title":[],"link":[{"URL":"https:\/\/www.por-journal.com\/articles\/10.3389\/pore.2023.1610884\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T04:11:56Z","timestamp":1674101516000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.por-journal.com\/articles\/10.3389\/pore.2023.1610884\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,19]]},"references-count":80,"alternative-id":["10.3389\/pore.2023.1610884"],"URL":"https:\/\/doi.org\/10.3389\/pore.2023.1610884","relation":{},"ISSN":["1532-2807"],"issn-type":[{"value":"1532-2807","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,19]]},"article-number":"1610884"}}