{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T02:45:40Z","timestamp":1777171540827,"version":"3.51.4"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T00:00:00Z","timestamp":1684108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002332","name":"Semmelweis Egyetem","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["por-journal.com"],"crossmark-restriction":true},"short-container-title":["Pathol. Oncol. Res."],"abstract":"<jats:p>In sicca syndrome patients the xerostomia, xerophthalmia and the serological findings may strongly suggest the autoimmune Sj\u00f6gren\u2019s syndrome, but the histological findings in the labial salivary gland biopsies do not always justify the suspected diagnosis. The aim of this study was to compare the histomorphological changes and the clinical findings in patients with pathologically established Sj\u00f6gren\u2019s syndrome and in cases with negative histology. A total of 133 labial biopsies have been retrospectively evaluated from 2015 to May 2022, and the characteristic Sj\u00f6gren\u2019s lesions were found in 67 cases. According to the clinical data, 34 cases proved to be primary, and 33 were associated (\u201csecondary\u201d) forms. In 66 cases, the histology did not justify Sj\u00f6gren\u2019s syndrome; a significant acinar loss, fibrolipomatous infiltration, and mild sialadenitis had led to the clinical symptoms. In Sj\u00f6gren\u2019s histologies, the acinar loss was detected in just 31.8% of cases, which might indicate that the diminished saliva production represents immune-mediated hypofunction rather than direct damage of the acini. This is the first systemic study in Hungary investigating the correlation between pathological alterations and clinical findings.<\/jats:p>","DOI":"10.3389\/pore.2023.1610905","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T09:28:37Z","timestamp":1684142917000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Correlations between the histopathological alterations in minor salivary glands and the clinically suspected Sj\u00f6gren\u2019s syndrome"],"prefix":"10.3389","volume":"29","author":[{"given":"M\u00e1ria","family":"Janka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"Zalatnai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"33","DOI":"10.2147\/OARRR.S167783","article-title":"Sj\u00f6gren\u2019s syndrome and systemic lupus erythematosus: Links and risks","volume":"11","author":"Pasoto","year":"2019","journal-title":"Open Access Rheumatol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1002\/acr.23173","article-title":"Prevalence of primary sj\u00f6gren's syndrome in a US population-based cohort","volume":"69","author":"Maciel","year":"2017","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"B3","doi-asserted-by":"publisher","first-page":"e25","DOI":"10.1136\/annrheumdis-2014-206860","article-title":"Is primary sj\u00f6gren's syndrome an orphan disease? 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