{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:37:11Z","timestamp":1753893431938,"version":"3.41.2"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["por-journal.com"],"crossmark-restriction":true},"short-container-title":["Pathol. Oncol. Res."],"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> Primary melanocytic tumors originating from CNS melanocytes are rare, with a low incidence of 0.7 cases per 10 million annually. This study focuses on primary leptomeningeal melanocytomas, emphasizing their epidemiology, clinical characteristics, and diagnostic challenges. Despite their infrequency, these tumors warrant attention due to their unique features and potential for local recurrence.<\/jats:p><jats:p><jats:bold>Case Report:<\/jats:bold> A 32-year-old female presented with syncope and seizures, leading to the discovery of two left-sided supratentorial lesions initially misidentified as convexity meningiomas. Detailed imaging suggested meningioma-like features, but intraoperative findings revealed unexpected hyperpigmented lesions. Histopathological examination, supported by immunohistochemistry, confirmed primary leptomeningeal melanocytoma. The surgical approach and subsequent management are discussed.<\/jats:p><jats:p><jats:bold>Discussion:<\/jats:bold> The discussion emphasizes challenges in diagnosing primary leptomeningeal melanocytomas. Treatment debates, especially regarding adjuvant radiotherapy, are explored. Recurrence risks stress the importance of vigilant follow-up, advocating for complete surgical resection as the primary approach. The rarity of supratentorial cases adds complexity to diagnosis, necessitating a multidisciplinary approach. Insights from this case contribute to understanding and managing primary leptomeningeal melanocytomas, addressing challenges in differentiation from more common tumors and prompting ongoing research for refined diagnostics and optimized treatments.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> This study contributes insights into primary leptomeningeal melanocytomas, highlighting their rarity in supratentorial regions. The case underscores the importance of a multidisciplinary approach, incorporating clinical, radiological, and histopathological expertise for accurate diagnosis and tailored management. Ongoing research is crucial to refine treatment strategies, enhance prognostic precision, and improve outcomes for individuals with this uncommon CNS neoplasm.<\/jats:p>","DOI":"10.3389\/pore.2023.1611482","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T04:11:42Z","timestamp":1704341502000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Supratentorial meningeal melanocytoma mimicking meningioma: case report and literature review"],"prefix":"10.3389","volume":"29","author":[{"given":"Mayle Gomes","family":"Ferreira de Ara\u00fajo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Euripedes","family":"Almondes Santana Lemos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Lucas","family":"Negromonte Guerra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"Marcia dos Santos Lima Didjurgeit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Auricelio","family":"Batista Cezar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor Vilela","family":"Faquini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hildo Rocha","family":"Cirne de Azevedo Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,1,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1097\/00000478-199907000-00001","article-title":"Primary melanocytic neoplasms of the central nervous systems","volume":"23","author":"Brat","year":"1999","journal-title":"Am J Surg Pathol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1111\/1523-1747.ep12260111","article-title":"The distribution of melanocytes in the leptomeninges of the human brain","volume":"82","author":"Goldgeier","year":"1984","journal-title":"J Invest Dermatol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1200\/JOP.2016.011882","article-title":"Management of brain metastases in patients with melanoma","volume":"12","author":"Chukwueke","year":"2016","journal-title":"J Oncol Pract"},{"key":"B4","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1590\/0004-282X-ANP-2021-0082","article-title":"Melanocytic lesions of the central nervous system: a case series","volume":"80","author":"Varela-Poblete","year":"2022","journal-title":"Arq Neuropsiquiatr"},{"key":"B5","first-page":"181","article-title":"Melanocytic lesions. 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