{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:33:11Z","timestamp":1788582791636,"version":"build-2803163510"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["por-journal.com"],"crossmark-restriction":true},"short-container-title":["Pathol. Oncol. Res."],"abstract":"<jats:p>Lung cancer, the leading cause of malignancy-related deaths worldwide, demands proactive measures to mitigate its impact. Low-dose computer tomography (LDCT) has emerged as a promising tool for secondary prevention through lung cancer screening (LCS). The HUNCHEST study, inspired by the success of international trials, including the National Lung Cancer Screening Trial and the Dutch NELSON study, embarked on the first LDCT-based LCS program in Hungary. The initiative assessed the screening efficiency, incorporating lung function tests and exploring the interplay between lung cancer and chronic obstructive pulmonary disease (COPD). Building upon this foundation, an implementation trial involving 18 Hungarian centers supported by the Ministry of Human Capacities demonstrated the feasibility of LCS within a multicentric framework. These centers, equipped with radiology capabilities, collaborated with multidisciplinary oncology teams, ensuring optimal patient pathways. However, a critical challenge remained the patient recruitment. To address this, the HUNCHEST 3 project, initiated in 2023, seeks to engage general practitioners (GPs) to reach out to eligible patients within a municipality collective of 60 thousand inhabitants. The project\u2019s ultimate success is contingent upon the willingness of eligible individuals to undergo LDCT scans. In conclusion, the HUNCHEST program represents a crucial step in advancing lung cancer screening in Hungary. With a focus on efficiency, multidisciplinary collaboration, and innovative patient recruitment strategies, it endeavors to contribute to the reduction of lung cancer mortality and serve as a blueprint for potential nationwide LCS programs.<\/jats:p>","DOI":"10.3389\/pore.2024.1611635","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T04:12:02Z","timestamp":1715227922000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["HUNCHEST projects\u2014advancing low-dose CT lung cancer screening in Hungary"],"prefix":"10.3389","volume":"30","author":[{"given":"Anna","family":"Kerpel-Fronius","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisztina","family":"Bogos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,5,9]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","DOI":"10.1057\/9781137384232_2","article-title":"Lung cancer and consumption in the nineteenth century: bodies, tissues, cells and the making of a rare disease","volume-title":"A history of lung cancer. Science, technology and medicine in modern history","author":"Timmermann","year":"2014"},{"key":"B2","volume-title":"4.1.1.25. Reported new malignant neoplasms*","year":"2023"},{"key":"B3","doi-asserted-by":"publisher","first-page":"170070","DOI":"10.1098\/rsob.170070","article-title":"Progress and prospects of early detection in lung cancer","volume":"7","author":"Blandin Knight","year":"2017","journal-title":"Open Biol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1002\/ijc.2910450107","article-title":"Lack of benefit from semi-annual screening for cancer of the lung: follow-up report of a randomized controlled trial on a population of high-risk males in Czechoslovakia","volume":"45","author":"Kubik","year":"1990","journal-title":"Int J Cancer"},{"key":"B5","doi-asserted-by":"publisher","first-page":"324S","DOI":"10.1378\/chest.89.4_Supplement.324S-a","article-title":"Survival and mortality from lung cancer in a screened population","volume":"89","author":"Tockman","year":"1986","journal-title":"CHEST"},{"key":"B6","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1097\/00043764-198608000-00038","article-title":"Lung cancer screening: the Mayo program","volume":"28","author":"Fontana","year":"1986","journal-title":"J Occup Med"},{"key":"B7","volume-title":"Prostate, lung, colorectal, and ovarian cancer screening trial (PLCO)","year":"2023"},{"key":"B8","first-page":"2491","article-title":"Gondolatok a t\u00fcd\u0151r\u00e1k sz\u0171r\u0151vizsg\u00e1lat\u00e1r\u00f3l","volume":"139","author":"Ostoros","year":"1998","journal-title":"Orvosi Hetilap"},{"key":"B9","volume-title":"Kor\u00e1nyi bulletin","year":"2023"},{"key":"B10","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/S0140-6736(99)06093-6","article-title":"Early Lung Cancer Action Project: overall design and findings from baseline screening","volume":"354","author":"Henschke","year":"1999","journal-title":"Lancet"},{"key":"B11","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1056\/NEJMoa1102873","article-title":"Reduced lung-cancer mortality with low-dose computed tomographic screening","volume":"365","author":"Aberle","year":"2011","journal-title":"N Engl J Med"},{"key":"B12","volume-title":"Lung cancer: scrrening","year":"2021"},{"key":"B13","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.chest.2019.08.2176","article-title":"Lung cancer screening uptake in the United States","volume":"157","author":"Yong","year":"2020","journal-title":"Chest"},{"key":"B14","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1056\/NEJMoa1911793","article-title":"Reduced lung-cancer mortality with volume CT screening in a randomized trial","volume":"382","author":"de Koning","year":"2020","journal-title":"N Engl J Med"},{"key":"B15","doi-asserted-by":"publisher","first-page":"2519","DOI":"10.1007\/s00330-015-3697-0","article-title":"ESR\/ERS white paper on lung cancer screening","volume":"25","author":"Kauczor","year":"2015","journal-title":"Eur Radiol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"e754","DOI":"10.1016\/S1470-2045(17)30861-6","article-title":"European position statement on lung cancer screening","volume":"18","author":"Oudkerk","year":"2017","journal-title":"Lancet Oncol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"4457","DOI":"10.1007\/s00330-022-08589-7","article-title":"Nationwide lung cancer screening with low-dose computed tomography: implementation and first results of the HUNCHEST screening program","volume":"32","author":"Kerpel-Fronius","year":"2022","journal-title":"Eur Radiol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.vhri.2022.10.002","article-title":"Shall we screen lung cancer with low-dose computed tomography? Cost-effectiveness in Hungary","volume":"34","author":"Nagy","year":"2023","journal-title":"Value Health Reg Issues"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-023-10379-8","article-title":"HUNCHEST-II contributes to a shift to earlier-stage lung cancer detection: final results of a nationwide screening program","author":"Kerpel-Fronius","year":"2023","journal-title":"Eur Radiol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"3856","DOI":"10.3390\/cancers14163856","article-title":"Deep learning algorithms for diagnosis of lung cancer: a systematic review and meta-analysis","volume":"14","author":"Forte","year":"2022","journal-title":"Cancers"},{"key":"B21","doi-asserted-by":"publisher","first-page":"100329","DOI":"10.1016\/j.jtocrr.2022.100329","article-title":"Implementing lung cancer screening in Europe: taking a systems approach","volume":"3","author":"Wait","year":"2022","journal-title":"JTO Clin Res Rep"},{"key":"B22","volume-title":"Blog","year":"2024"},{"key":"B23","volume-title":"Sebastian Schmidt: lung cancer screening \u2013 results from Croatia","author":"Schmidt","year":"2024"},{"key":"B24","volume-title":"LDCT screening pilots in Poland","year":"2022"},{"key":"B25","volume-title":"Prevenceproplice","year":"2024"},{"key":"B26","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/j.jtho.2020.10.158","article-title":"Lung cancer in Austria","volume":"16","author":"Pirker","year":"2021","journal-title":"J Thorac Oncol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"109","DOI":"10.4149\/BLL_2023_016","article-title":"Lung cancer screening initiative in Slovakia: guidelines of screening implementation","volume":"124","author":"Juskanic","year":"2023","journal-title":"Bratisl Lek Listy"},{"key":"B28","doi-asserted-by":"publisher","first-page":"2326","DOI":"10.21037\/jtd-21-1172","article-title":"Thoracic surgery in Slovenia","volume":"14","author":"\u0160tupnik","year":"2022","journal-title":"J Thorac Dis"},{"key":"B29","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1016\/j.jtho.2022.04.010","article-title":"Lung cancer in Serbia","volume":"17","author":"Cavic","year":"2022","journal-title":"J Thorac Oncol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1001\/jamainternmed.2016.9022","article-title":"Implementation of lung cancer screening in the Veterans health administration","volume":"177","author":"Kinsinger","year":"2017","journal-title":"JAMA Intern Med"},{"key":"B31","volume-title":"Strengthening the screening of lung cancer in Europe","year":"2023"}],"container-title":["Pathology and Oncology Research"],"original-title":[],"link":[{"URL":"https:\/\/www.por-journal.com\/articles\/10.3389\/pore.2024.1611635\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T04:12:07Z","timestamp":1715227927000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.por-journal.com\/articles\/10.3389\/pore.2024.1611635\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,9]]},"references-count":31,"alternative-id":["10.3389\/pore.2024.1611635"],"URL":"https:\/\/doi.org\/10.3389\/pore.2024.1611635","relation":{},"ISSN":["1532-2807"],"issn-type":[{"value":"1532-2807","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,9]]},"article-number":"1611635"}}