{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T20:44:04Z","timestamp":1782333844420,"version":"3.54.5"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["por-journal.com"],"crossmark-restriction":true},"short-container-title":["Pathol. Oncol. Res."],"abstract":"<jats:p>Sebaceous carcinoma (SC) is a rare aggressive malignant tumor that originates in the adnexal epithelium of the sebaceous gland. While occurrences on the lips are extremely uncommon, there have been a few reported cases in the literature. Our case involves a 47-year-old smoker male who presented with a painless, non-mobile lesion on his upper lip that had been present for 12\u00a0months. Upon clinical examination, an ulcerated, exophytic, and irregularly shaped mass was observed on the upper lip. No other intraoral lesions were found. An incisional biopsy was performed, revealing a malignant tumor with a nodular pattern consisting of basaloid cells with obvious sebaceous differentiations and frequent mitoses. The neoplastic cells tested positive for broad-spectrum cytokeratin (AE1-AE3), epithelial membrane antigen (EMA), and P53, while testing negative for S-100 and carcinoembryonic antigen (CEA). Based on these results, a diagnosis of SC of the upper lip was made. This case report and review aimed to describe the histogenesis, unique clinicopathological features, and current treatment options for SC.<\/jats:p>","DOI":"10.3389\/pore.2024.1611968","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T04:11:26Z","timestamp":1731039086000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case report: A rare case of oral sebaceous carcinoma in the upper lip"],"prefix":"10.3389","volume":"30","author":[{"given":"Yousef","family":"Katib","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murad","family":"Essatari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"key":"B1","first-page":"pp25","article-title":"Sebaceous carcinoma of the conjunctiva and caruncle","volume-title":"WHO classification of tumours of the eye","author":"Dubovy","year":"2018"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1001\/archotol.1992.01880110113020","article-title":"Sebaceous carcinoma of the head and neck. Case report and literature review","volume":"118","author":"Bailet","year":"1992","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"B3","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.tripleo.2004.05.007","article-title":"Sebaceous carcinoma of the oral mucosa: case report and review of the literature","volume":"99","author":"Alawi","year":"2005","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"B4","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/s0266-4356(03)00036-6","article-title":"Intraoral sebaceous carcinoma","volume":"41","author":"Handschel","year":"2003","journal-title":"Br J Oral Maxillofac Surg"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1007\/s10792-018-0925-z","article-title":"Ocular sebaceous gland carcinoma: an update of the literature","volume":"39","author":"Cicinelli","year":"2019","journal-title":"Int Ophthalmol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.3390\/diagnostics13101676","article-title":"Sebaceous neoplasms","volume":"13","author":"Papadimitriou","year":"2023","journal-title":"Diagnostics (Basel)"},{"key":"B7","first-page":"401","article-title":"Sebaceous carcinoma of salivary gland. Report of two cases of infrequent location","volume":"24","author":"Esnal Leal","year":"1997","journal-title":"An Otorrinolaringol Ibero Am"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1016\/0030-4220(53)90220-5","article-title":"The occurrence of Fordyce spots, benign migratory glossitis, median rhomboid glossitis, and fissured tongue in 2,478 dental patients","volume":"6","author":"Halperin","year":"1953","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.21037\/gs-21-218","article-title":"Sebaceous carcinoma of the right palate: case report and literature review","volume":"10","author":"Lu","year":"2021","journal-title":"Gland Surg"},{"key":"B10","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/0030-4220(91)90016-6","article-title":"Intraoral sebaceous carcinoma","volume":"72","author":"Damm","year":"1991","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1002\/jso.20383","article-title":"Morpheaform extraocular sebaceous carcinoma","volume":"92","author":"Innocenzi","year":"2005","journal-title":"J Surg Oncol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1177\/1742271X15569295","article-title":"Sebaceous carcinoma of the lip: comparing normal lip and cheek anatomy with the imaging features of a rare cutaneous malignancy","volume":"23","author":"Greenall","year":"2015","journal-title":"Ultrasound"},{"key":"B13","doi-asserted-by":"publisher","first-page":"217","DOI":"10.5794\/jjoms.61.217","article-title":"A case of sebaceous carcinoma of the lower lip","volume":"61","author":"Arai","year":"2015","journal-title":"Jpn J Oral Maxillofacial Surg"},{"key":"B14","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1186\/s13256-022-03435-2","article-title":"Sebaceous carcinoma of the lip: a case report and review of the literature","volume":"16","author":"Di Cosola","year":"2022","journal-title":"J Med Case Rep"},{"key":"B15","doi-asserted-by":"publisher","first-page":"p126","DOI":"10.1016\/j.phoj.2022.08.002","article-title":"Squamous cell carcinoma admixed with sebaceous carcinoma of upper lip in a 7-year-old female","volume":"7","author":"Benedict","year":"2022","journal-title":"Ped Hem Onco J"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1001\/jamadermatol.2014.1217","article-title":"Screening for germline mismatch repair mutations following diagnosis of sebaceous neoplasm","volume":"150","author":"Everett","year":"2014","journal-title":"JAMA Dermatol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1002\/cncr.23952","article-title":"A retrospective review of 1349 cases of sebaceous carcinoma","volume":"115","author":"Dasgupta","year":"2009","journal-title":"Cancer"},{"key":"B18","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1111\/j.1524-4725.2004.30025.x","article-title":"Biological behavior of the sebaceous carcinoma of the head","volume":"30","author":"Bassetto","year":"2004","journal-title":"Dermatol Surg"},{"key":"B19","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1046\/j.1524-4725.2003.29268.x","article-title":"Extraorbital sebaceous carcinoma with rapidly developing visceral metastases","volume":"29","author":"Duman","year":"2003","journal-title":"Dermatol Surg"},{"key":"B20","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1159\/000310872","article-title":"Management of eyelid sebaceous carcinomas","volume":"211","author":"Dogru","year":"1997","journal-title":"Ophthalmologica"},{"key":"B21","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1017\/s0022215100134103","article-title":"Intraoral sebaceous carcinoma","volume":"110","author":"Abuzeid","year":"1996","journal-title":"J Laryngol Otol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"3643","DOI":"10.14456\/apjcp.2016.148\/APJCP.2016.17.7.3643","article-title":"Radiation therapy for primary eyelid cancers in Tunisia","volume":"17","author":"Belaid","year":"2016","journal-title":"Asian Pac J Cancer Prev"},{"key":"B23","doi-asserted-by":"publisher","first-page":"337","DOI":"10.3892\/ol.2023.13923","article-title":"Ocular and extraocular sebaceous carcinomas: a retrospective study with emphasis on the presence of in situ lesion and discussion and review of the histogenesis of extraocular sebaceous carcinoma","volume":"26","author":"Takeuchi","year":"2023","journal-title":"Oncol Lett"},{"key":"B24","doi-asserted-by":"publisher","first-page":"347","DOI":"10.3349\/ymj.2003.44.2.347","article-title":"A case of superficial epithelioma with sebaceous differentiation","volume":"44","author":"Lee","year":"2003","journal-title":"Yonsei Med J"},{"key":"B25","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1111\/j.1600-0560.1987.tb01331.x","article-title":"Superficial epithelioma with sebaceous differentiation","volume":"14","author":"Friedman","year":"1987","journal-title":"J Cutan Pathol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1111\/j.1440-1827.1998.tb03907.x","article-title":"Sebaceous carcinoma of the submandibular gland with high-grade malignancy: report of a case","volume":"48","author":"Ohara","year":"1998","journal-title":"Pathol Int"},{"key":"B27","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1034\/j.1600-0714.2003.00037.x","article-title":"A case of sebaceous carcinoma of the parotid gland","volume":"32","author":"Siriwardena","year":"2003","journal-title":"J Oral Pathol Med"}],"container-title":["Pathology and Oncology Research"],"original-title":[],"link":[{"URL":"https:\/\/www.por-journal.com\/articles\/10.3389\/pore.2024.1611968\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T04:11:34Z","timestamp":1731039094000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.por-journal.com\/articles\/10.3389\/pore.2024.1611968\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,8]]},"references-count":27,"alternative-id":["10.3389\/pore.2024.1611968"],"URL":"https:\/\/doi.org\/10.3389\/pore.2024.1611968","relation":{},"ISSN":["1532-2807"],"issn-type":[{"value":"1532-2807","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,8]]},"article-number":"1611968"}}