{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:37:17Z","timestamp":1788237437066,"version":"build-2803163510"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["por-journal.com"],"crossmark-restriction":true},"short-container-title":["Pathol. Oncol. Res."],"abstract":"<jats:p>This case study delves into the link, between exposure to Bisphenol A (BPA) and kidney issues filling a gap in human focused research found in studies. The individual, a 72-year man with a history of BPA exposure in a plastics manufacturing facility experienced a gradual decline in kidney function over 18\u00a0months. Medical tests showed kidney disease with a buildup of lipofuscin in renal tubular cells upon examination. This discovery suggests a connection between BPA exposure and kidney damage underscoring the need for investigation. The lack of human based evidence highlights the importance of research to understand the toxic effects of BPA on the kidneys. In addition, to its implications this case emphasizes the importance of improving safety protocols and raising awareness among healthcare professionals in relevant work environments to reduce potential health risks associated with BPA exposure.<\/jats:p>","DOI":"10.3389\/pore.2025.1612046","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T05:10:20Z","timestamp":1751865020000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: Toxic tubulointerstitial nephropathy with lipofuscin deposition \u2013 the potential cause of occupational Bisphenol-A exposition"],"prefix":"10.3389","volume":"31","author":[{"given":"L\u00e1szl\u00f3","family":"Bidiga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Csonka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"M\u00e9hes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csilla","family":"Mark\u00f3th","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e1vid","family":"Hutkai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1nos","family":"M\u00e1tyus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3978","DOI":"10.2903\/j.efsa.2015.3978","article-title":"Scientific Opinion on the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs: opinion on BPA","volume":"13","year":"2016","journal-title":"EFSA J"},{"key":"B2","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1542\/peds.2009-2693","article-title":"Bisphenol A and related compounds in dental materials","volume":"126","author":"Fleisch","year":"2010","journal-title":"Pediatrics"},{"key":"B3","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1097\/HJH.0000000000000780","article-title":"Serum bisphenol A as a predictor of chronic kidney disease progresion in primary hypertension: a 6-year prospective study","volume":"34","author":"Hu","year":"2016","journal-title":"J Hypertens"},{"key":"B4","first-page":"299","article-title":"Bisphenol A (BPA) in food contact materials - 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