{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T09:10:01Z","timestamp":1776157801534,"version":"3.50.1"},"reference-count":10,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["por-journal.com"],"crossmark-restriction":true},"short-container-title":["Pathol. Oncol. Res."],"abstract":"<jats:p>\n                    Anastomotic hemangioma (AH) is a rare benign vascular tumor primarily occurring in the genitourinary tract; however, only two cases have been reported in the thigh. In this report, a 42-year-old female patient presented to the hospital for examination due to \u201ca subcutaneous mass on the lateral aspect of the left thigh discovered 9 months ago, which has been gradually enlarging.\u201d Subsequently, the lump was removed via local surgery. Histological examination reveals: At low magnification, the tumor was situated within the superficial subcutaneous fascia layer, presenting a loose lobular structure. Most of its margins were well - defined, while a small portion displayed expansile infiltrative changes. There were well - differentiated vascular lumens arranged in a communicating or anastomosing pattern, along with pseudopapillary structures. At high magnification, tumor cells were oval or short spindle - shaped, with vacuoles in the cytoplasm that contain red blood cells or homogeneously red - stained glassy globules. Moderate atypia was present, and mitotic activity was frequent, with hot spots averaging approximately 4\/mm\n                    <jats:sup>2<\/jats:sup>\n                    . PCR-\n                    <jats:italic>GNAQ<\/jats:italic>\n                    mutation detection result: detected a missense mutation at codon 209 in exon 5 (\n                    <jats:italic>c.627A&amp;gt;T, p. Q209H<\/jats:italic>\n                    ). Follow-up revealed tumor recurrence 10\u00a0months after surgery. Given the rarity of AH occurring on skin surfaces, coupled with the high proliferative activity observed in this case and its recurrence following excision, we report the diagnostic and therapeutic process along with the clinical and pathological features of this AH case. This aims to enhance the understanding of this disease among clinicians and pathologists.\n                  <\/jats:p>","DOI":"10.3389\/pore.2026.1612402","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T08:18:34Z","timestamp":1776154714000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Thigh anastomotic hemangioma"],"prefix":"10.3389","volume":"32","author":[{"given":"Li","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pathology, Deyang Hospital Affiliated Hospital of Chengdu University of Traditional Chinese Medicine","place":["Deyang, Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Pengzhou People\u2019s Hospital","place":["Chengdu, Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Daying People\u2019s Hospital","place":["Suining, Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"B1","volume-title":"Soft tissue and bone tumours [M]","year":"2020"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1097\/PAS.0b013e3181ad30a7","article-title":"Anastomosing hemangioma of the genitourinary tract: a lesion mimicking angiosarcoma","volume":"33","author":"Montgomery","year":"2009","journal-title":"Am J Surg Pathol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"3108","DOI":"10.3390\/jcm14093108","article-title":"Systematic review and case report of a left gonadal vein anastomosing hemangioma","volume":"14","author":"Hoxhaj","year":"2025","journal-title":"J Clin Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1111\/cup.13426","article-title":"A primary cutaneous vascular neoplasm with histologic features of anastomosing hemangioma","volume":"46","author":"Tran","year":"2019","journal-title":"J Cutan Pathol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.3760\/cma.j.cn112151-20220721-00629","article-title":"Clinicopathological and molecular genetic features of anastomosing hemangioma","volume":"51","author":"Xiong","year":"2022","journal-title":"Chin J Pathol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2335","DOI":"10.1007\/s00261-2022-03559-5","article-title":"Anastomosing hemangioma: a current update on clinical, pathological and imaging features","volume":"47","author":"Shanbhogue","year":"2022","journal-title":"Abdom Radiol (Ny)"},{"key":"B7","doi-asserted-by":"publisher","first-page":"698","DOI":"10.3760\/cma.j.issn.05295807.2016.10.006","article-title":"Clinicopathologic analysis of anastomosing hemangioma of the kidney and adrenal gland","volume":"45","author":"Zhao","year":"2016","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"B8","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1097\/PAS.0000000000002127","article-title":"Papillary hemangioma harbors somatic GNA11 and GNAQ mutations","volume":"48","author":"Gestrich","year":"2024","journal-title":"Am J Surg Pathol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1007\/s00428-2019-02673-y","article-title":"GNA11 joins GNAQ and GNA14 as a recurrently mutated gene in anastomosing hemangioma","volume":"476","author":"Liau","year":"2020","journal-title":"Virchows Arch"},{"key":"B10","doi-asserted-by":"publisher","first-page":"650","DOI":"10.22037\/uj.v0i0.5514","article-title":"Anastomosing hemangioma incidentally found in kidney or adrenal gland: study of 10 cases and review of literature","volume":"13","author":"Zhou","year":"2020","journal-title":"Urol J"}],"container-title":["Pathology &amp; Oncology Research"],"original-title":[],"link":[{"URL":"https:\/\/www.por-journal.com\/articles\/10.3389\/pore.2026.1612402\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T08:18:58Z","timestamp":1776154738000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.por-journal.com\/articles\/10.3389\/pore.2026.1612402\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,14]]},"references-count":10,"alternative-id":["10.3389\/pore.2026.1612402"],"URL":"https:\/\/doi.org\/10.3389\/pore.2026.1612402","relation":{},"ISSN":["1532-2807"],"issn-type":[{"value":"1532-2807","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,14]]},"article-number":"1612402"}}