{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T21:37:03Z","timestamp":1780349823647,"version":"3.54.1"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontierspartnerships.org"],"crossmark-restriction":true},"short-container-title":["Transpl Int"],"abstract":"<jats:p>Relationships between renal function and medical costs for deceased donor kidney transplant recipients are not fully quantified post-transplant. We describe these relationships with renal function measured by estimated glomerular filtration rate (eGFR) and graft failure. The United States Renal Data System identified adults receiving single-organ deceased donor kidneys 2012\u20132015. Inpatient, outpatient, other facility costs and eGFRs at discharge, 6 and 12\u00a0months were included. A time-history of costs was constructed for graft failures and monthly costs in the first year post-transplant were compared to those without failure. The cohort of 24,021 deceased donor recipients had a 2.4% graft failure rate in the first year. Total medical costs exhibit strong trends with eGFR. Recipients with 6-month eGFRs of 30\u201359\u00a0ml\/min\/1.73m<jats:sup>2<\/jats:sup> have total costs 48% lower than those &amp;lt;30\u00a0ml\/min\/1.73m<jats:sup>2<\/jats:sup>. For recipients with graft failure monthly costs begin to rise 3\u20134\u00a0months prior to failure, with incremental costs of over $38,000 during the month of failure. Mean annual total incremental costs of graft failure are over $150,000. Total costs post-transplant are strongly correlated with eGFR. Graft failure in the first year is an expensive, months-long process. Further reductions in early graft failures could yield significant human and economic benefits.<\/jats:p>","DOI":"10.3389\/ti.2022.10422","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T04:11:35Z","timestamp":1653624695000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Costs in the Year Following Deceased Donor Kidney Transplantation: Relationships With Renal Function and Graft 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