{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:12:47Z","timestamp":1784257967138,"version":"3.55.0"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontierspartnerships.org"],"crossmark-restriction":true},"short-container-title":["Transpl Int"],"abstract":"<jats:p>Pancreas transplants from expanded criteria donors are performed widely in Japan because there is a shortage of brain-dead donors. However, the effectiveness of this strategy is unknown. We retrospectively studied 371 pancreas transplants to evaluate the possibility of pancreas transplantation from expanded criteria donors by the Pancreas Donor Risk Index (PDRI). Patients were divided into five groups according to quintiles of PDRI values (Q1\u2013Q5). The 1-year pancreas graft survival rates were 94.5% for Q1, 91.9% for Q2, 90.5% for Q3, 89.3% for Q4, and 79.6% for Q5, and were significantly lower with a lower PDRI (<jats:italic>p<\/jats:italic> = 0.04). A multivariate analysis showed that the PDRI, donor hemoglobin A1c values, and pancreas transplantation alone significantly predicted 1-year pancreas graft survival (all <jats:italic>p<\/jats:italic> &amp;lt; 0.05). Spline curve analysis showed that the PDRI was incrementally associated with an increased risk of 1-year graft failure. In the group with a PDRI \u2265 2.87, 8\/56 patients had graft failures within 1\u00a0month, and all were due to graft thrombosis. The PDRI is a prognostic factor related to the 1-year graft survival rate. However, pancreas transplantation from high-PDRI donors shows acceptable results and could be an alternative when the donor pool is insufficient.<\/jats:p>","DOI":"10.3389\/ti.2023.11132","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T04:11:35Z","timestamp":1684296695000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Utilization of the Pancreas From Donors With an Extremely High Pancreas Donor Risk Index: Report of the National Registry of Pancreas Transplantation"],"prefix":"10.3389","volume":"36","author":[{"given":"Keizo","family":"Kaku","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Okabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsuke","family":"Kubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Noguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshito","family":"Tomimaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshinori","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kenmochi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1097\/00000658-200003000-00015","article-title":"Simultaneous Pancreas-Kidney Transplantation and Living Related Donor Renal Transplantation in Patients with Diabetes: Is There a Difference in Survival?","volume":"231","author":"Rayhill","year":"2000","journal-title":"Ann Surg"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1097\/TP.0000000000000663","article-title":"A Reassessment of the Survival Advantage of Simultaneous Kidney-Pancreas versus Kidney-Alone Transplantation","volume":"99","author":"Sung","year":"2015","journal-title":"Transplantation"},{"key":"B3","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1111\/ctr.12511","article-title":"Health-related Quality of Life May Improve after Transplantation in Pancreas-Kidney Recipients","volume":"29","author":"Martins","year":"2015","journal-title":"Clin Transpl"},{"key":"B4","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1111\/nep.13523","article-title":"Health-related Quality of Life Following Kidney and Simultaneous Pancreas Kidney Transplantation","volume":"24","author":"Rajkumar","year":"2019","journal-title":"Nephrology"},{"key":"B5","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.transproceed.2014.12.048","article-title":"Living Donor Kidney Transplantation Preceding Pancreas Transplantation Reduces Mortality in Type 1 Diabetics with End-Stage Renal Disease","volume":"47","author":"Kaku","year":"2015","journal-title":"Transpl Proc"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.1111\/j.1600-6143.2004.00667.x","article-title":"Mortality Assessment for Pancreas Transplants","volume":"4","author":"Gruessner","year":"2004","journal-title":"Am J Transpl"},{"key":"B7","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1002\/ags3.12423","article-title":"Current State of Pancreas Transplantation in Japan Based on the Nationwide Registry","volume":"5","author":"Tomimaru","year":"2021","journal-title":"Ann Gastroenterol Surg"},{"key":"B8","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.pan.2021.01.002","article-title":"Clinical Impact of Pancreas Donor Age on Outcomes Following Pancreas Transplantation: Analysis of a Nationwide Registry in Japan","volume":"21","author":"Tomimaru","year":"2021","journal-title":"Pancreatology"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1111\/tri.13636","article-title":"Are the Outcomes of Japanese Pancreas Transplantation Utilizing Extended-Criteria Donors Acceptable? 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